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Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53

  • Authors:
    • Rongfeng Liu
    • Hongchen Li
    • Yanzhao Xu
    • Xing Li
    • Xiaojin Guo
    • Jian Shi
    • Yanzhi Cui
    • Zhiyu Wang
    • Junfeng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Immuno‑Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Third Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 6
    |
    Published online on: November 3, 2020
       https://doi.org/10.3892/ol.2020.12267
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Abstract

Human esophageal cancer (hESC) cell motility adopts various modes, resulting in hESC progression and poor survival. However, how tripartite motif 59 (TRIM59), as the ubiquitination machinery, participates in hESC metastasis is not completely understood. The results indicated that TRIM59 was aberrantly upregulated in hESC tissues compared with adjacent healthy esophageal tissues, which was associated with poor survival and advanced TNM state among patients with hESC. Moreover, patients with hESC with higher TRIM59 expression displayed undetectable p53 expression, which contributed to enhanced progression and motility of hESC. At the molecular level, TRIM59 was indicated to be an E3 putative ubiquitin ligase that targeted the p53 protein, leading to increased degradation of p53, which resulted in decreased chemosensitivity to cisplatin. TRIM59 knockdown reduced TRIM59 expression, increased p53 protein expression, and decreased hESC cell viability, clone formation and migration compared with the small interfering RNA negative control (siNC) group. Furthermore, hESC cell lines were more sensitive to cisplatin in the TRIM59‑knockdown group compared with the siNC group. The results indicated a relationship between TRIM59, p53 and the chemosensitivity of cisplatin. The present study suggested that TRIM59 may serve as a promising prognostic indicator for patients with hESC.
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1 

Esposito D, Koliopoulos MG and Rittinger K: Structural determinants of TRIM protein function. Biochem Soc Trans. 45:183–191. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Hatakeyama S: TRIM family proteins: Roles in autophagy, immunity, and carcinogenesis. Trends Biochem Sci. 42:297–311. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Hatakeyama S: TRIM proteins and cancer. Nat Rev Cancer. 11:792–804. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Nabeshima K, Inoue T, Shimao Y and Sameshima T: Matrix metalloproteinases in tumor invasion: Role for cell migration. Pathol Int. 52:255–264. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Scheau C, Badarau IA, Costache R, Caruntu C, Mihai GL, Didilescu AC, Constantin C and Neagu M: The role of matrix metalloproteinases in the epithelial-mesenchymal transition of hepatocellular carcinoma. Anal Cell Pathol (Amst). 94:239072019.

6 

Yanqing L, Omid T and Wei G: p53 modifications: Exquisite decorations of the powerful guardian. J Mol Cell Biol. 11:564–577. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Malkin D: Li-fraumeni syndrome. Genes Cancer. 2:475–484. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Guha T and Malkin D: Inherited TP53 mutations and the Li-Fraumeni syndrome. Cold Spring Harb Perspect Med. 7:a0261872017. View Article : Google Scholar : PubMed/NCBI

9 

Freddie B, Jacques F, Isabelle S, Rebecca SL, Lindey TA and Ahmedin J: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Jackie Oh S, Han S, Lee W and Lockhart AC: Emerging immunotherapy for the treatment of esophageal cancer. Expert Opin Investig Drugs. 25:667–677. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Zhang F, Wang Y, Wang ZQ, Sun P, Wang DS, Jiang YX, Zhang DS, Wang FH, Xu RH and Li YH: Efficacy and safety of cisplatin-based versus nedaplatin-based regimens for the treatment of metastatic/recurrent and advanced esophageal squamous cell carcinoma: A systematic review and meta-analysis. Dis Esophagus. 30:1–8. 2017. View Article : Google Scholar

12 

Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W and Zhou Y: TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biol. 16:e30000512018. View Article : Google Scholar : PubMed/NCBI

13 

Wang Z and Li C, Li Y, Guo X, Yan Z, Gao F and Li C: DpdtbA-induced growth inhibition in human esophageal cancer cells involved inactivation of the p53/EGFR/AKT pathway. Oxid Med Cell Longev. 2019:54146702019. View Article : Google Scholar : PubMed/NCBI

14 

Valletti A, Marzano F, Pesole G, Sbisa E and Tullo A: Targeting chemoresistant tumors: Could trim proteins-p53 axis be a possible answer? Int J Mol Sci. 20:17762019. View Article : Google Scholar

15 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Rustgi A and El-Serag HB: Esophageal carcinoma. N Engl J Med. 372:1472–1473. 2015.PubMed/NCBI

17 

Hao L, Du B and Xi X: TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. Oncol Lett. 14:2153–2164. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Cui Z, Liu Z, Zeng J, Zhang S, Chen L, Zhang G, Xu W, Song L and Guo X: TRIM59 promotes gefitinib resistance in EGFR mutant lung adenocarcinoma cells. Life Sci. 224:23–32. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Luo D, Wang Y, Huan X, Huang C, Yang C, Fan H, Xu Z and Yang L: Identification of a synonymous variant in TRIM59 gene for gastric cancer risk in a Chinese population. Oncotarget. 8:11507–11516. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Lin WY, Wang H, Song X, Zhang SX, Zhou PS, Sun JM and Li JS: Knockdown of tripartite motif 59 (TRIM59) inhibits tumor growth in prostate cancer. Eur Rev Med Pharmacol Sci. 20:4864–4873. 2016.PubMed/NCBI

21 

Zhang Y and Yang W: Down-regulation of tripartite motif protein 59 inhibits proliferation, migration and invasion in breast cancer cells. Biomed Pharmacother. 89:462–467. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Tan P, He L and Zhou Y: TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10. Autophagy. 15:747–749. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Wu W, Chen J, Wu J, Lin J, Yang S and Yu H: Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells. Oncol Rep. 38:2480–2488. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Shen H, Zhang J, Zhang Y, Feng Q, Wang H, Li G, Jiang W and Li X: Knockdown of tripartite motif 59 (TRIM59) inhibits proliferation in cholangiocarcinoma via the PI3K/AKT/mTOR signalling pathway. Gene. 698:50–60. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Aierken G, Seyiti A, Alifu M and Kuerban G: Knockdown of tripartite-59 (trim59) inhibits cellular proliferation and migration in human cervical cancer cells. Oncol Res. 25:381–388. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Chen G, Chen W, Ye M, Tan W and Jia B: TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma. Biosci Rep. 39:BSR201812772019. View Article : Google Scholar : PubMed/NCBI

27 

Xu Y, Zhang Z and Xu G: TRIM proteins in neuroblastoma. Biosci Rep. 39:BSR201920502019. View Article : Google Scholar : PubMed/NCBI

28 

Gao R, Lv G, Zhang C, Wang X and Chen L: TRIM59 induces epithelial-to-mesenchymal transition and promotes migration and invasion by PI3K/AKT signaling pathway in medulloblastoma. Oncol Lett. 15:8253–8260. 2018.PubMed/NCBI

29 

Wang Y, Zhou Z, Wang X, Zhang X, Chen Y, Bai J and Di W: Trim59 is a novel marker of poor prognosis and promotes malignant progression of ovarian cancer by inducing annexin a2 expression. Int J Biol Sci. 14:2073–2082. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Zhang P, Zhang H, Wang Y, Zhang P and Qi Y: Tripartite motif-containing protein 59 (TRIM59) promotes epithelial ovarian cancer progression via the focal adhesion kinase(FAK)/AKT/Matrix metalloproteinase (MMP) pathway. Med Sci Monit. 25:3366–3373. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Khatamianfar V, Valiyeva F, Rennie PS, Lu W, Yang BB, Bauman G, Moussa M and Xuan JW: TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis. BMJ Open. 2:e0014102012. View Article : Google Scholar : PubMed/NCBI

32 

Huang XP, Li X, Situ MY, Huang LY, Wang J, He T, Yan QH, Xie XY, Zhang YJ, Gao YH, et al: Entinostat reverses cisplatin resistance in esophageal squamous cell carcinoma via down-regulation of multidrug resistance gene 1. Cancer Lett. 414:294–300. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Ilson DH: Esophageal cancer chemotherapy: Recent advances. Gastrointest Cancer Res. 2:85–92. 2008.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu R, Li H, Xu Y, Li X, Guo X, Shi J, Cui Y, Wang Z and Liu J: Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53. Oncol Lett 21: 6, 2021.
APA
Liu, R., Li, H., Xu, Y., Li, X., Guo, X., Shi, J. ... Liu, J. (2021). Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53. Oncology Letters, 21, 6. https://doi.org/10.3892/ol.2020.12267
MLA
Liu, R., Li, H., Xu, Y., Li, X., Guo, X., Shi, J., Cui, Y., Wang, Z., Liu, J."Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53". Oncology Letters 21.1 (2021): 6.
Chicago
Liu, R., Li, H., Xu, Y., Li, X., Guo, X., Shi, J., Cui, Y., Wang, Z., Liu, J."Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53". Oncology Letters 21, no. 1 (2021): 6. https://doi.org/10.3892/ol.2020.12267
Copy and paste a formatted citation
x
Spandidos Publications style
Liu R, Li H, Xu Y, Li X, Guo X, Shi J, Cui Y, Wang Z and Liu J: Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53. Oncol Lett 21: 6, 2021.
APA
Liu, R., Li, H., Xu, Y., Li, X., Guo, X., Shi, J. ... Liu, J. (2021). Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53. Oncology Letters, 21, 6. https://doi.org/10.3892/ol.2020.12267
MLA
Liu, R., Li, H., Xu, Y., Li, X., Guo, X., Shi, J., Cui, Y., Wang, Z., Liu, J."Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53". Oncology Letters 21.1 (2021): 6.
Chicago
Liu, R., Li, H., Xu, Y., Li, X., Guo, X., Shi, J., Cui, Y., Wang, Z., Liu, J."Blockade of TRIM59 enhances esophageal cancer cell chemosensitivity to cisplatin by upregulating p53". Oncology Letters 21, no. 1 (2021): 6. https://doi.org/10.3892/ol.2020.12267
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