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Article

Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab

  • Authors:
    • Kengo Kuriyama
    • Takehiko Yokobori
    • Makoto Sohda
    • Nobuhiro  Nakazawa
    • Toshiki  Yajima
    • Ichiro Naruse
    • Hiroyuki  Kuwano
    • Ken Shirabe
    • Kyoichi Kaira
    • Hiroshi Saeki
  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371‑8511, Japan, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Maebashi, Gunma 371‑8511, Japan, Division of Respiratory Medicine, Hidaka Hospital, Takasaki, Gunma 370‑0001, Japan, Department of Respiration Medicine, Saitama Medical University, International Medical Center, Hidaka, Saitama 350‑1298, Japan
  • Article Number: 11
    |
    Published online on: November 3, 2020
       https://doi.org/10.3892/ol.2020.12272
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Abstract

Plastin‑3 (PLS3) is a circulating tumor cell marker associated with aggressive cancer phenotypes. The present study aimed to investigate the usability of plasma PLS3 concentration in assessing the diagnosis, prognosis and sensitivity to treatment in patients with non‑small‑cell lung cancer (NSCLC) treated with nivolumab. A total of 33 patients with recurrent or advanced NSCLC were treated with nivolumab, and 10 healthy volunteers were retrospectively enrolled. Plasma concentrations of PLS3 were determined by ELISA. Plasma PLS3 concentration in patients with NSCLC was significantly higher compared with that in healthy volunteers (median 7.64 ng/ml vs. 3.13 ng/ml, P<0.001). Univariate analysis indicated that PLS3 ≤5.43 ng/ml was a predictor of partial response. Patients with PLS3 >8.55 ng/ml exhibited a poorer prognosis compared with those in the PLS3 ≤8.55 ng/ml group. A high plasma PLS3 concentration was a predictor of poor overall survival. In conclusion, plasma PLS3 concentration was identified as a marker for the diagnosis, treatment sensitivity and prognosis in patients with NSCLC treated with nivolumab. Plasma PLS3 may be a clinically useful tumor marker in patients with NSCLC; future prospective studies may confirm these results and explore its use in other cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Kuriyama K, Yokobori T, Sohda M, Nakazawa N, Yajima T, Naruse I, Kuwano H, Shirabe K, Kaira K, Saeki H, Saeki H, et al: Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab. Oncol Lett 21: 11, 2021.
APA
Kuriyama, K., Yokobori, T., Sohda, M., Nakazawa, N., Yajima, T., Naruse, I. ... Saeki, H. (2021). Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab. Oncology Letters, 21, 11. https://doi.org/10.3892/ol.2020.12272
MLA
Kuriyama, K., Yokobori, T., Sohda, M., Nakazawa, N., Yajima, T., Naruse, I., Kuwano, H., Shirabe, K., Kaira, K., Saeki, H."Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab". Oncology Letters 21.1 (2021): 11.
Chicago
Kuriyama, K., Yokobori, T., Sohda, M., Nakazawa, N., Yajima, T., Naruse, I., Kuwano, H., Shirabe, K., Kaira, K., Saeki, H."Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab". Oncology Letters 21, no. 1 (2021): 11. https://doi.org/10.3892/ol.2020.12272
Copy and paste a formatted citation
x
Spandidos Publications style
Kuriyama K, Yokobori T, Sohda M, Nakazawa N, Yajima T, Naruse I, Kuwano H, Shirabe K, Kaira K, Saeki H, Saeki H, et al: Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab. Oncol Lett 21: 11, 2021.
APA
Kuriyama, K., Yokobori, T., Sohda, M., Nakazawa, N., Yajima, T., Naruse, I. ... Saeki, H. (2021). Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab. Oncology Letters, 21, 11. https://doi.org/10.3892/ol.2020.12272
MLA
Kuriyama, K., Yokobori, T., Sohda, M., Nakazawa, N., Yajima, T., Naruse, I., Kuwano, H., Shirabe, K., Kaira, K., Saeki, H."Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab". Oncology Letters 21.1 (2021): 11.
Chicago
Kuriyama, K., Yokobori, T., Sohda, M., Nakazawa, N., Yajima, T., Naruse, I., Kuwano, H., Shirabe, K., Kaira, K., Saeki, H."Plasma plastin‑3: A tumor marker in patients with non‑small‑cell lung cancer treated with nivolumab". Oncology Letters 21, no. 1 (2021): 11. https://doi.org/10.3892/ol.2020.12272
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