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Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer

  • Authors:
    • Cheng Song
    • Bo Pan
    • Xiao Yang
    • Wei Tang
  • View Affiliations / Copyright

    Affiliations: Department of Chinese Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, First Department of Oncology, Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha, Hunan 410013, P.R. China, Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410013, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
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    Published online on: November 11, 2020
       https://doi.org/10.3892/ol.2020.12286
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Abstract

Colorectal cancer (CRC) is one of the most common types of human cancer. However, there is still an urgent need to identify novel treatment strategies for CRC. The present study aimed to validate the potential antitumor effects of polyphyllin VII in CRC. The present study revealed that polyphyllin VII could significantly inhibit CRC proliferation and induce cell cycle arrest and apoptosis. Moreover, the anti‑metastatic effect of polyphyllin VII in CRC cells was implicated. Microarray analysis identified that polyphyllin VII could affect multiple protein coding genes and non‑coding RNAs. Bioinformatics analysis revealed that polyphyllin VII regulated multiple pathways in CRC, including ‘ER to Golgi vesicle‑mediated transport’, ‘response to cAMP’, ‘Ras protein signal transduction’, ‘metabolic pathways’, ‘MAPK signaling pathway’ and ‘cell cycle’. Protein‑Protein Interaction network analysis identified a series of key polyphyllin VII‑regulating genes in CRC, including ribonucleoside‑diphosphate reductase subunit M2, structural maintenance of chromosomes protein 4 and DNA replication licensing factor MCM4. Finally, the present results demonstrated that these key polyphyllin VII‑regulating genes were dysregulated in CRC. Taken together, these results indicated that polyphyllin VII could be a novel antitumor drug for the treatment of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Song C, Pan B, Yang X and Tang W: Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer. Oncol Lett 21: 25, 2021.
APA
Song, C., Pan, B., Yang, X., & Tang, W. (2021). Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer. Oncology Letters, 21, 25. https://doi.org/10.3892/ol.2020.12286
MLA
Song, C., Pan, B., Yang, X., Tang, W."Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer". Oncology Letters 21.1 (2021): 25.
Chicago
Song, C., Pan, B., Yang, X., Tang, W."Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer". Oncology Letters 21, no. 1 (2021): 25. https://doi.org/10.3892/ol.2020.12286
Copy and paste a formatted citation
x
Spandidos Publications style
Song C, Pan B, Yang X and Tang W: Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer. Oncol Lett 21: 25, 2021.
APA
Song, C., Pan, B., Yang, X., & Tang, W. (2021). Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer. Oncology Letters, 21, 25. https://doi.org/10.3892/ol.2020.12286
MLA
Song, C., Pan, B., Yang, X., Tang, W."Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer". Oncology Letters 21.1 (2021): 25.
Chicago
Song, C., Pan, B., Yang, X., Tang, W."Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer". Oncology Letters 21, no. 1 (2021): 25. https://doi.org/10.3892/ol.2020.12286
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