Open Access

MicroRNA‑126: A new and promising player in lung cancer (Review)

  • Authors:
    • Qijun Chen
    • Shuanghua Chen
    • Juanjuan Zhao
    • Ya Zhou
    • Lin Xu
  • View Affiliations

  • Published online on: November 12, 2020     https://doi.org/10.3892/ol.2020.12296
  • Article Number: 35
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is one of the most common malignant tumors associated with cancer death; however, the mechanisms involved in lung tumor development have not been completely elucidated, which impedes the advancement of clinical diagnosis and therapy. MicroRNA‑126 (miR‑126) is an important member of the microRNA family and is encoded by intron 7 of epidermal growth factor‑like domain‑containing gene 7. Increasing evidence has demonstrated that miR‑126, as a distinct endothelial‑enriched miRNA and new tumor suppressor gene, serves a promising role in the occurrence, development and metastasis of various types of cancer, including liver cancer, colorectal cancer, melanoma and lung cancer. In the present review, the current knowledge of the role of miR‑126 in lung cancer growth, metastasis, diagnosis and prognosis as well as therapy was summarized, which may provide new insights on the biological roles of miRNAsin lung cancer and facilitate the ultimate development of miRNA‑based therapies in clinical patients with non‑small cell lung cancer.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Q, Chen S, Zhao J, Zhou Y and Xu L: MicroRNA‑126: A new and promising player in lung cancer (Review). Oncol Lett 21: 35, 2021
APA
Chen, Q., Chen, S., Zhao, J., Zhou, Y., & Xu, L. (2021). MicroRNA‑126: A new and promising player in lung cancer (Review). Oncology Letters, 21, 35. https://doi.org/10.3892/ol.2020.12296
MLA
Chen, Q., Chen, S., Zhao, J., Zhou, Y., Xu, L."MicroRNA‑126: A new and promising player in lung cancer (Review)". Oncology Letters 21.1 (2021): 35.
Chicago
Chen, Q., Chen, S., Zhao, J., Zhou, Y., Xu, L."MicroRNA‑126: A new and promising player in lung cancer (Review)". Oncology Letters 21, no. 1 (2021): 35. https://doi.org/10.3892/ol.2020.12296