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SDF1α/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment

  • Authors:
    • Masakazu Yashiro
    • Haruhito Kinoshita
    • Gen Tsujio
    • Tatsunari Fukuoka
    • Yurie Yamamoto
    • Tomohiro Sera
    • Atsushi Sugimoto
    • Sadaaki Nishimura
    • Shuhei Kushiyama
    • Shingo Togano
    • Kenji Kuroda
    • Takahiro Toyokawa
    • Masaichi Ohira
  • View Affiliations / Copyright

    Affiliations: Molecular Oncology and Therapeutics, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan, Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
    Copyright: © Yashiro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
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    Published online on: November 12, 2020
       https://doi.org/10.3892/ol.2020.12299
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Abstract

Stromal cell‑derived factor 1α (SDF1α) and its receptor C‑X‑C chemokine receptor type 4 (CXCR4) have been reported to form an important chemokine signaling pathway. Our previous study reported that SDF1α from tumor stromal cells may stimulate the proliferation of gastric cancer (GC) cells through the CXCR4 axis in a hypoxic microenvironment. However, a limited number of studies have addressed the clinicopathological significance of the expression of SDF1α and CXCR4 in GC, particularly at hypoxic regions. Immunohistochemistry was used to investigate the expression levels of SDF1α, CXCR4 and the hypoxic marker carbonic anhydrase 9 (CA9) in 185 patients with stage II and III GC. The results demonstrated that CA9 was expressed on cancer and stromal cells in hypoxic lesions, CXCR4 was mainly expressed in cancer cells, and SDFα was mainly expressed in stromal cells. CXCR4 expression in cancer cells and SDFα expression in stromal cells were associated with the hypoxic regions with CA9 expression. The CA9 and CXCR4 expression in the cancer cells, and the SDF1α expression in the stromal cells (CA9/CXCR4/SDF1α) was significantly associated with macroscopic type 4 tumor (P=0.012) and the pattern of tumor infiltration into the surrounding tissue (P<0.001). The prognosis of the all CA9/CXCR4/SDF1α‑positive patients was significantly poorer compared with that of patients with CA9‑, CXCR4‑ or SDF1α‑negative GC at Stage III (P=0.041). These results indicated that hypoxia may upregulate SDFα production in stromal cells and CXCR4 expression in cancer cells. The SDF1α/CXCR4 axis may serve an important role in the progression of GC.
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1 

Global Burden of Disease Cancer Collaboration, ; Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, et al: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Miki Y, Yashiro M, Ando K, Okuno T, Kitayama K, Masuda G, Tamura T, Sakurai K, Toyokawa T, Kubo N, et al: Examination of cancer cells exposed to gastric serosa by serosal stamp cytology plus RT-PCR is useful for the identification of gastric cancer patients at high risk of peritoneal recurrence. Surg Oncol. 26:352–358. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Togano S, Yashiro M, Miki Y, Yamamoto Y, Sera T, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Kuroda K, et al: Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer. PLoS One. 15:e02259582020. View Article : Google Scholar : PubMed/NCBI

4 

Kinoshita H, Yashiro M, Fukuoka T, Hasegawa T, Morisaki T, Kasashima H, Masuda G, Noda S and Hirakawa K: Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments. Carcinogenesis. 36:1511–1520. 2015.PubMed/NCBI

5 

Lee HJ and Jo DY: The role of the CXCR4/CXCL12 axis and its clinical implications in gastric cancer. Histol Histopathol. 27:1155–1161. 2012.PubMed/NCBI

6 

Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:50–56. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Gockel I, Schimanski CC, Heinrich C, Wehler T, Frerichs K, Drescher D, von Langsdorff C, Domeyer M, Biesterfeld S, Galle PR, et al: Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma. BMC Cancer. 6:2902006. View Article : Google Scholar : PubMed/NCBI

8 

Engl T, Relja B, Blumenberg C, Müller I, Ringel EM, Beecken WD, Jonas D and Blaheta RA: Prostate tumor CXC-chemokine profile correlates with cell adhesion to endothelium and extracellular matrix. Life Sci. 78:1784–1793. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Wu QY, Yang CK, Rong LJ, Li JC and Lei LM: Investigation of the association between C-X-C motif chemokine receptor subunits and tumor infiltration levels and prognosis in patients with early-stage pancreatic ductal adenocarcinoma. Oncol Lett. 20:162020.PubMed/NCBI

10 

Katsumoto K and Kume S: The role of CXCL12-CXCR4 signaling pathway in pancreatic development. Theranostics. 3:11–17. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Scala S, Giuliano P, Ascierto PA, Ieranò C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, et al: Human melanoma metastases express functional CXCR4. Clin Cancer Res. 12:2427–2433. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Zhang SS, Han ZP, Jing YY, Tao SF, Li TJ, Wang H, Wang Y, Li R, Yang Y, Zhao X, et al: CD133+CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med. 10:852012. View Article : Google Scholar : PubMed/NCBI

13 

Chiaramonte R, Colombo M, Bulfamante G, Falleni M, Tosi D, Garavelli S, De Simone D, Vigolo E, Todoerti K, Neri A and Platonova N: Notch pathway promotes ovarian cancer growth and migration via CXCR4/SDF1alpha chemokine system. Int J Biochem Cell Biol. 66:134–140. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Cavallaro S: CXCR4/CXCL12 in non-small-cell lung cancer metastasis to the brain. Int J Mol Sci. 14:1713–1727. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kitayama K, Yashiro M, Morisaki T, Miki Y, Okuno T, Kinoshita H, Fukuoka T, Kasashima H, Masuda G, Hasegawa T, et al: Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer. Cancer Sci. 108:2462–2469. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Kato Y, Yashiro M, Noda S, Kashiwagi S, Matsuoka J, Fuyuhiro Y, Doi Y and Hirakawa K: Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma. Digestion. 82:246–251. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Noda S, Yashiro M, Nshii T and Hirakawa K: Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cells. Eur J Cancer. 46:995–1005. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Matsuoka J, Yashiro M, Doi Y, Fuyuhiro Y, Kato Y, Shinto O, Noda S, Kashiwagi S, Aomatsu N, Hirakawa T, et al: Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signaling. PLoS One. 8:e623102013. View Article : Google Scholar : PubMed/NCBI

19 

Hirakawa T, Yashiro M, Doi Y, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Kimura K, Amano R and Hirakawa K: Pancreatic fibroblasts stimulate the motility of pancreatic cancer cells through IGF1/IGF1R signaling under hypoxia. PLoS One. 11:e01599122016. View Article : Google Scholar : PubMed/NCBI

20 

Kasashima H, Yashiro M, Kinoshita H, Fukuoka T, Morisaki T, Masuda G, Sakurai K, Kubo N, Ohira M and Hirakawa K: Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia. Gastric Cancer. 19:431–442. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Kasashima H, Yashiro M, Nakamae H, Kitayama K, Masuda G, Kinoshita H, Fukuoka T, Hasegawa T, Nakane T, Hino M, et al: CXCL1-Chemokine (C-X-C Motif) receptor 2 signaling stimulates the recruitment of bone marrow-derived mesenchymal cells into diffuse-type gastric cancer stroma. Am J Pathol. 186:3028–3039. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Kasashima H, Yashiro M, Nakamae H, Masuda G, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, et al: Bone marrow-derived stromal cells are associated with gastric cancer progression. Br J Cancer. 113:443–452. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Yashiro M, Matsuoka T and Ohira M: The significance of scirrhous gastric cancer cell lines: The molecular characterization using cell lines and mouse models. Hum Cell. 31:271–281. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Okuno T, Yashiro M, Masuda G, Togano S, Kuroda K, Miki Y, Hirakawa K, Ohsawa M, Wanibuchi H and Ohira M: Establishment of a new scirrhous gastric cancer cell line with FGFR2 overexpression, OCUM-14. Ann Surg Oncol. 26:1093–1102. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Oh YS, Kim HY, Song IC, Yun HJ, Jo DY, Kim S and Lee HY: Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α. Oncol Rep. 28:2239–2246. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Romain B, Hachet-Haas M, Rohr S, Brigand C, Galzi JL, Gaub MP, Pencreach E and Guenot D: Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. Mol Cancer. 13:582014. View Article : Google Scholar : PubMed/NCBI

27 

Japanese Gastric Cancer Association: Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Greene FL and Sobin LH: A worldwide approach to the TNM staging system: Collaborative efforts of the AJCC and UICC. J Surg Oncol. 99:269–272. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Shephard DA: The 1975 declaration of helsinki and consent. Can Med Assoc J. 115:1191–1192. 1976.PubMed/NCBI

30 

Eckert AW, Horter S, Bethmann D, Kotrba J, Kaune T, Rot S, Bache M, Bilkenroth U, Reich W, Greither T, et al: Investigation of the prognostic role of carbonic anhydrase 9 (CAIX) of the cellular mRNA/protein level or soluble CAIX protein in patients with oral squamous cell carcinoma. Int J Mol Sci. 20:3752019. View Article : Google Scholar

31 

Hitchon C, Wong K, Ma G, Reed J, Lyttle D and El-Gabalawy H: Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum. 46:2587–2597. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Liu H, Liu S, Li Y, Wang X, Xue W, Ge G and Luo X: The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS One. 7:e346082012. View Article : Google Scholar : PubMed/NCBI

33 

Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T and Honjo T: Signal sequence trap: A cloning strategy for secreted proteins and type I membrane proteins. Science. 261:600–603. 1993. View Article : Google Scholar : PubMed/NCBI

34 

Iwasa S, Yanagawa T, Fan J and Katoh R: Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis. Anticancer Res. 29:4751–4758. 2009.PubMed/NCBI

35 

Zhao BC, Wang ZJ, Mao WZ, Ma HC, Han JG, Zhao B and Xu HM: CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. World J Gastroenterol. 17:2389–2396. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, et al: Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res. 66:2181–2187. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Koshiba T, Hosotani R, Miyamoto Y, Ida J, Tsuji S, Nakajima S, Kawaguchi M, Kobayashi H, Doi R, Hori T, et al: Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression. Clin Cancer Res. 6:3530–3535. 2000.PubMed/NCBI

38 

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL and Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Jiang Q, Sun Y and Liu X: CXCR4 as a prognostic biomarker in gastrointestinal cancer: A meta-analysis. Biomarkers. 24:510–516. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Yu C and Zhang Y: Characterization of the prognostic values of CXCR family in gastric cancer. Cytokine. 123:1547852019. View Article : Google Scholar : PubMed/NCBI

41 

Ishigami S, Natsugoe S, Okumura H, Matsumoto M, Nakajo A, Uenosono Y, Arigami T, Uchikado Y, Setoyama T, Arima H, et al: Clinical implication of CXCL12 expression in gastric cancer. Ann Surg Oncol. 14:3154–3158. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Nayak A, Roy AD, Rout N, Singh SP, Bhattacharyya A and Roychowdhury A: HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia. Biochem Biophys Res Commun. 523:916–923. 2020. View Article : Google Scholar : PubMed/NCBI

43 

de Barros Moreira Beltrão H, de Paula Cerroni M, de Freitas DR, das Neves Pinto AY, da Costa Valente V, Valente SA, de Góes Costa E and Sobel J: Investigation of two outbreaks of suspected oral transmission of acute chagas disease in the amazon region, para state, Brazil, in 2007. Trop Doct. 39:231–232. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Li Q, Zhu CC, Ni B, Zhang ZZ, Jiang SH, Hu LP, Wang X, Zhang XX, Huang PQ, Yang Q, et al: Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts. EBioMedicine. 49:157–171. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Bubnovskaya L and Osinsky D: Tumor microenvironment and metabolic factors: Contribution to gastric cancer. Exp Oncol. 42:2–10. 2020.PubMed/NCBI

46 

Zhang WJ, Chen C, Zhou ZH, Gao ST, Tee TJ, Yang LQ, Xu YX, Pang TH, Xu XY, Sun Q, et al: Hypoxia-inducible factor-1 alpha correlates with tumor-associated macrophages infiltration, influences survival of gastric cancer patients. J Cancer. 8:1818–1825. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Kato Y, Yashiro M, Fuyuhiro Y, Kashiwagi S, Matsuoka J, Hirakawa T, Noda S, Aomatsu N, Hasegawa T, Matsuzak T, et al: Effects of acute and chronic hypoxia on the radiosensitivity of gastric and esophageal cancer cells. Anticancer Res. 31:3369–3375. 2011.PubMed/NCBI

48 

Al-Juboori SI, Vadakekolathu J, Idri S, Wagner S, Zafeiris D, Rd Pearson J, Almshayakhchi R, Caraglia M, Desiderio V, Miles AK, et al: PYK2 promotes HER2-positive breast cancer invasion. J Exp Clin Cancer Res. 38:2102019. View Article : Google Scholar : PubMed/NCBI

49 

Liu S, Jia X, Li C, Han X, Yan W and Xing Y: CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1alpha after hypoxia. PLoS One. 8:e552902013. View Article : Google Scholar : PubMed/NCBI

50 

Kato Y, Yashiro M, Noda S, Tendo M, Kashiwagi S, Doi Y, Nishii T, Matsuoka J, Fuyuhiro Y, Shinto O, et al: Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/hypo, derived from a scirrhous gastric carcinoma. Br J Cancer. 102:898–907. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yashiro M, Kinoshita H, Tsujio G, Fukuoka T, Yamamoto Y, Sera T, Sugimoto A, Nishimura S, Kushiyama S, Togano S, Togano S, et al: SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Oncol Lett 21: 38, 2021.
APA
Yashiro, M., Kinoshita, H., Tsujio, G., Fukuoka, T., Yamamoto, Y., Sera, T. ... Ohira, M. (2021). SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Oncology Letters, 21, 38. https://doi.org/10.3892/ol.2020.12299
MLA
Yashiro, M., Kinoshita, H., Tsujio, G., Fukuoka, T., Yamamoto, Y., Sera, T., Sugimoto, A., Nishimura, S., Kushiyama, S., Togano, S., Kuroda, K., Toyokawa, T., Ohira, M."SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment". Oncology Letters 21.1 (2021): 38.
Chicago
Yashiro, M., Kinoshita, H., Tsujio, G., Fukuoka, T., Yamamoto, Y., Sera, T., Sugimoto, A., Nishimura, S., Kushiyama, S., Togano, S., Kuroda, K., Toyokawa, T., Ohira, M."SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment". Oncology Letters 21, no. 1 (2021): 38. https://doi.org/10.3892/ol.2020.12299
Copy and paste a formatted citation
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Spandidos Publications style
Yashiro M, Kinoshita H, Tsujio G, Fukuoka T, Yamamoto Y, Sera T, Sugimoto A, Nishimura S, Kushiyama S, Togano S, Togano S, et al: SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Oncol Lett 21: 38, 2021.
APA
Yashiro, M., Kinoshita, H., Tsujio, G., Fukuoka, T., Yamamoto, Y., Sera, T. ... Ohira, M. (2021). SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Oncology Letters, 21, 38. https://doi.org/10.3892/ol.2020.12299
MLA
Yashiro, M., Kinoshita, H., Tsujio, G., Fukuoka, T., Yamamoto, Y., Sera, T., Sugimoto, A., Nishimura, S., Kushiyama, S., Togano, S., Kuroda, K., Toyokawa, T., Ohira, M."SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment". Oncology Letters 21.1 (2021): 38.
Chicago
Yashiro, M., Kinoshita, H., Tsujio, G., Fukuoka, T., Yamamoto, Y., Sera, T., Sugimoto, A., Nishimura, S., Kushiyama, S., Togano, S., Kuroda, K., Toyokawa, T., Ohira, M."SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment". Oncology Letters 21, no. 1 (2021): 38. https://doi.org/10.3892/ol.2020.12299
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