Biological effects of corosolic acid as an anti‑inflammatory, anti‑metabolic syndrome and anti‑neoplasic natural compound (Review)
- Authors:
- Jinwei Zhao
- Hong Zhou
- Yanan An
- Keshu Shen
- Lu Yu
-
Affiliations: Key Laboratory for Zoonosis Research, Department of Hepatopancreatobiliary Surgery, Institute of Zoonosis, The Second Hospital of Jilin University, Ministry of Education, College of Veterinary Medicine Jilin University, Changchun, Jilin 130062, P.R. China, Department of Hepatobiliary Medicine of Jilin Hepatobiliary Hospital, Changchun, Jilin 130062, P.R. China - Published online on: December 2, 2020 https://doi.org/10.3892/ol.2020.12345
- Article Number: 84
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|
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chen WQ, Li H, Sun KX, Zheng RS, Zhang SW, Zeng HM, Zou XN, Gu XY and He J: Report of cancer incidence and mortality in China, 2014. Zhonghua Zhong Liu Za Zhi. 40:5–13. 2018.(In Chinese). PubMed/NCBI | |
|
Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144:1941–1953. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Islami F, Goding Sauer A, Miller KD, Siegel RL, Fedewa SA, Jacobs EJ, McCullough ML, Patel AV, Ma J, Soerjomataram I, et al: Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin. 68:31–54. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Khan M, Maryam A, Qazi JI and Ma T: Targeting apoptosis and multiple signaling pathways with icariside II in cancer cells. Int J Biol Sci. 11:1100–1112. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Millimouno FM, Dong J, Yang L, Li J and Li X: Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev Res (Phila). 7:1081–1107. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Khan M, Maryam A, Zhang H, Mehmood T and Ma T: Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med. 20:389–402. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Faivre S, Djelloul S and Raymond E: New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors. Semin Oncol. 33:407–420. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Shu L, Cheung KL, Khor TO, Chen C and Kong AN: Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev. 29:483–502. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ye B, Li J, Li Z, Yang J, Niu T and Wang S: Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo. J Ethnopharmacol. 153:258–267. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yan Y, Xu Z, Dai S, Qian L, Sun L and Gong Z: Targeting autophagy to sensitive glioma to temozolomide treatment. J Exp Clin Cancer Res. 35:232016. View Article : Google Scholar : PubMed/NCBI | |
|
Rengarajan T, Nandakumar N, Rajendran P, Haribabu L, Nishigaki I and Balasubramanian MP: D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pac J Cancer Prev. 15:1757–1762. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Montaser R and Luesch H: Marine natural products: A new wave of drugs? Future Med Chem. 3:1475–1489. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Efferth T: From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy. Semin Cancer Biol. 46:65–83. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng CS, Chen J, Tan HY, Wang N, Chen Z and Feng Y: Scutellaria baicalensis and cancer treatment: Recent progress and perspectives in biomedical and clinical studies. Am J Chin Med. 46:25–54. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Shanmugam MK, Dai X, Kumar AP, Tan BK, Sethi G and Bishayee A: Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence. Cancer Lett. 346:206–216. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Salvador JAR, Leal AS, Valdeira AS, Gonçalves BMF, Alho DPS, Figueiredo SAC, Silvestre SM and Mendes VIS: Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment. Eur J Med Chem. 142:95–130. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD, Brown DM, et al: Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med. 1:1046–1051. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Knowles J and Gromo G: A guide to drug discovery: Target selection in drug discovery. Nat Rev Drug Discov. 2:63–69. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Strüh CM, Jäger S, Schempp CM, Scheffler A and Martin SF: A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells. Phytother Res. 26:1507–1512. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Y, He J, Li J, Peng X, Wang X, Dong Z, Zhao E, Liu Y, Wu Z and Cui H: Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells. Cell Death Dis. 8:e31332017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu W, Liu X, Pan Z, Wang D, Li M, Chen X, Zhou L, Xu M, Li D and Zheng Q: Ailanthone induces cell cycle arrest and apoptosis in melanoma B16 and A375 cells. Biomolecules. 9:2752019. View Article : Google Scholar | |
|
Tiwari R, Puthli A, Balakrishnan S, Sapra BK and Mishra KP: Betulinic acid-induced cytotoxicity in human breast tumor cell lines MCF-7 and T47D and its modification by tocopherol. Cancer Invest. 32:402–408. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Mullauer FB, van Bloois L, Daalhuisen JB, Ten Brink MS, Storm G, Medema JP, Schiffelers RM and Kessler JH: Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity. Anticancer Drugs. 22:223–233. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Fulda S, Jeremias I, Steiner HH, Pietsch T and Debatin KM: Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells. Int J Cancer. 82:435–441. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Sivakumar G, Vail DR, Nair V, Medina-Bolivar F and Lay JO Jr: Plant-based corosolic acid: Future anti-diabetic drug? Biotechnol J. 4:1704–1711. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Leng J, Li JJ, Tang JF, Li Y, Liu BL and Wen XD: Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice. Phytomedicine. 23:181–190. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ulbricht C, Dam C, Milkin T, Seamon E, Weissner W and Woods J: Banaba (Lagerstroemia speciosa L.): An evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother. 7:99–113. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Park C and Lee JS: Banaba: The natural remedy as antidiabetic drug. Biomed Res. 22:127–131. 2011. | |
|
Kim E, Sy-Cordero A, Graf TN, Brantley SJ, Paine MF and Oberlies NH: Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. Planta Med. 77:265–270. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Aguirre MC, Delporte C, Backhouse N, Erazo S, Letelier ME, Cassels BK, Silva X, Alegría S and Negrete R: Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorg Med Chem. 14:5673–5677. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Hou W, Li Y, Zhang Q, Wei X, Peng A, Chen L and Wei Y: Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors. Phytother Res. 23:614–618. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hu C, Chen L, Xin Y and Cai Q: Determination of corosolic acid in Eriobotrya japonica leaves by reversed-phase high performance liquid chromatography. Se Pu. 24:492–494. 2006.(In Chinese). PubMed/NCBI | |
|
Lv H, Chen J, Li WL and Zhang HQ: Studies on the triterpenes from loquat leaf (Eriobotrya japonica). Zhong Yao Cai. 31:1351–1354. 2008.(In Chinese). PubMed/NCBI | |
|
Lu H, Xi C, Chen J and Li W: Determination of triterpenoid acids in leaves of Eriobotrya japonica collected at in different seasons. Zhongguo Zhong Yao Za Zhi. 34:2353–2355. 2009.(In Chinese). PubMed/NCBI | |
|
Rollinger JM, Kratschmar DV, Schuster D, Pfisterer PH, Gumy C, Aubry EM, Brandstötter S, Stuppner H, Wolber G and Odermatt A: 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorg Med Chem. 18:1507–1515. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Banno N, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M, Watanabe K, Kimura Y, Hasegawa J and Nishino H: Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem. 68:85–90. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Kim DH, Han KM, Chung IS, Kim DK, Kim SH, Kwon BM, Jeong TS, Park MH, Ahn EM and Baek NI: Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: Cholesterol acyltransferase inhibitors. Arch Pharm Res. 28:550–556. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Na M, Yang S, He L, Oh H, Kim BS, Oh WK, Kim BY and Ahn JS: Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata. Planta Med. 72:261–263. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Thuong PT, Min BS, Jin W, Na M, Lee J, Seong R, Lee YM, Song K, Seong Y, Lee HK, et al: Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biol Pharm Bull. 29:830–833. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Lee MS and Thuong PT: Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytother Res. 24:49–53. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yang NY, Duan JA, Li P and Qian SH: Chemical Constituents of Glechoma longituba. Yao Xue Xue Bao. 41:431–434. 2006.PubMed/NCBI | |
|
Shen Y, Wang QH, Lin HW, Shu W, Zhou JB and Li ZY: Study on chemical constituents of Potentilla chinensis Ser. Zhong Yao Cai. 29:237–239. 2006.(In Chinese). PubMed/NCBI | |
|
Kang SH, Shi YQ and Yang CX: Triterpenoids and steroids of root of Rubus biflorus. Zhong Yao Cai. 31:1669–1671. 2008.(In Chinese). PubMed/NCBI | |
|
Liu P, Teng J, Zhang YW, Takaishi Y and Duan HQ: Chemical constituents from rhizome of Phlomis umbrosa. Yao Xue Xue Bao. 42:401–404. 2007.(In Chinese). PubMed/NCBI | |
|
Li YL, Dai HN, Ma GX, Zhang W, Wu TY, Wang YQ, Zou JM, Zhong XQ, Zhou YL, Yuan JQ, et al: A new triterpenic acid from the roots of Rosa laevigata. Yao Xue Xue Bao. 52:425–429. 2017.(In Chinese). PubMed/NCBI | |
|
Huang XY, Ma GX, Zhong XQ, Zhou YL, Dai HN, Wu HF, Zhu YD, Yang JS, Yuan JQ and Xu XD: Triterpene constituents from Rosa cymosa Tratt. Zhongguo Zhong Yao Za Zhi. 39:4637–4641. 2014.(In Chinese). PubMed/NCBI | |
|
Ku CY, Wang YR, Lin HY, Lu SC and Lin JY: Corosolic acid inhibits hepatocellular carcinoma cell migration by targeting the VEGFR2/Src/FAK pathway. PLoS One. 10:e01267252015. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng QL, Li HL, Li YC, Liu ZW, Guo XH and Cheng YJ: CRA(Crosolic Acid) isolated from Actinidia valvata Dunn. Radix induces apoptosis of human gastric cancer cell line BGC823 in vitro via down-regulation of the NF-κB pathway. Food Chem Toxicol. 105:475–485. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Manayi A, Saeidnia S, Ostad SN, Hadjiakhoondi A, Ardekani MR, Vazirian M, Akhtar Y and Khanavi M: Chemical constituents and cytotoxic effect of the main compounds of Lythrum salicaria L. Z Naturforsch C J Biosci. 68:367–375. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kim JH, Kim YH, Song GY, Kim DE, Jeong YJ, Liu KH, Chung YH and Oh S: Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. Food Chem Toxicol. 67:87–95. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Horlad H, Fujiwara Y, Takemura K, Ohnishi K, Ikeda T, Tsukamoto H, Mizuta H, Nishimura Y, Takeya M and Komohara Y: Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells. Mol Nutr Food Res. 57:1046–1054. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Yoo KH, Park JH, Lee DY, Hwang-Bo J, Baek NI and Chung IS: Corosolic acid exhibits anti-angiogenic and anti-lymphangiogenic effects on in vitro endothelial cells and on an in vivo CT-26 colon carcinoma animal model. Phytother Res. 29:714–723. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Wu R, Li W, Gao L, Yang Y, Li P and Kong AN: The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells. Mol Carcinog. 57:512–521. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yong QX, Jian HZ and Xing SY: Corosolic acid induces potent anti-cancer effects in CaSki cervical cancer cells through the induction of apoptosis, cell cycle arrest and PI3K/Akt signalling pathway. Bangladesh J Pharmacol. 11:453–459. 2016. View Article : Google Scholar | |
|
National Cancer Institute (NIH), . Surveillance, Epidemiology, and End Results (SEER) Program. NIH. 2016.simplehttps://seer.cancer.gov/ | |
|
Baffy G: Hepatocellular carcinoma in non-alcoholic fatty liver disease: Epidemiology, pathogenesis, and prevention. J Clin Transl Hepatol. 1:131–137. 2013.PubMed/NCBI | |
|
Wong SW, Ting YW and Chan WK: Epidemiology of non-alcoholic fatty liver disease-related hepatocellular carcinoma and its implications. JGH Open. 2:235–241. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rinella ME: Nonalcoholic fatty liver disease: A systematic review. JAMA. 313:2263–2273. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Starley BQ, Calcagno CJ and Harrison SA: Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection. Hepatology. 51:1820–1832. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Welzel TM, Graubard BI, Zeuzem S, El-Serag HB, Davila JA and Mcglynn KA: Metabolic syndrome increases the risk of primary liver cancer in the United States: A study in the SEER-medicare database. Hepatology. 54:463–471. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hotamisligil GS: Inflammation and metabolic disorders. Nature. 444:860–867. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Stickel F and Hellerbrand C: Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: Mechanisms and implications. Gut. 59:1303–1307. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H and Karin M: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 140:197–208. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ish-Shalom D, Christoffersen CT, Vorwerk P, Sacerdoti-Sierra N, Shymko RM, Naor D and De Meyts P: Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor. Diabetologia. 40 (Suppl 2):S25–S31. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Buzzelli G, Dattolo P, Pinzani M, Brocchi A, Romano S and Gentilini P: Circulating growth hormone and insulin-like growth factor-I in nonalcoholic liver cirrhosis with or without superimposed hepatocarcinoma: Evidence of an altered circadian rhythm. Am J Gastroenterol. 88:1744–1748. 1993.PubMed/NCBI | |
|
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M and Hotamisligil GS: A central role for JNK in obesity and insulin resistance. Nature. 420:333–336. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Chang Q, Zhang Y, Beezhold KJ, Bhatia D, Zhao H, Chen J, Castranova V, Shi X and Chen F: Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol. 50:323–233. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA and Diehl AM: Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys. 378:259–268. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Ikura Y, Mita E and Nakamori S: Hepatocellular carcinomas can develop in simple fatty livers in the setting of oxidative stress. Pathology. 43:167–168. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, et al: NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature. 531:253–257. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, et al: Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 26:549–564. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Stohs SJ, Miller H and Kaats GR: A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res. 26:317–324. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma H, Kumar P, Deshmukh RR, Bishayee A and Kumar S: Pentacyclic triterpenes: New tools to fight metabolic syndrome. Phytomedicine. 50:166–177. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Fife CM, McCarroll JA and Kavallaris M: Movers and shakers: Cell cytoskeleton in cancer metastasis. Br J Pharmacol. 171:5507–5523. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chiang AC and Massagué J: Molecular basis of metastasis. N Engl J Med. 359:2814–2823. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Wang JN, Tang JM, Kong X, Yang JY, Zheng F, Guo LY, Huang YZ, Zhang L, Tian L, et al: VEGF is essential for the growth and migration of human hepatocellular carcinoma cells. Mol Biol Rep. 39:5085–5093. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lang SA, Brecht I, Moser C, Obed A, Batt D, Schlitt HJ, Geissler EK and Stoeltzing O: Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model. Langenbecks Arch Surg. 393:333–341. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, Lin Z, Liang C, Chen T, Chen L, et al: Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways. PLoS One. 8:e652642013. View Article : Google Scholar : PubMed/NCBI | |
|
Xu Y, Zhao Y, Xu Y, Guan Y, Zhang X, Chen Y, Wu Q, Zhu G, Chen Y, Sun F, et al: Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer. Cell Signal. 29:209–217. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lee MS, Cha EY, Thuong PT, Kim JY, Ahn MS and Sul JY: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. Biol Pharm Bull. 33:931–937. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lee MS, Lee CM, Cha EY, Thuong PT, Bae K, Song IS, Noh SM and Sul JY: Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis. Phytother Res. 24:1857–1861. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sung B, Kang YJ, Kim DH, Hwang SY, Lee Y, Kim M, Yoon JH, Kim CM, Chung HY and Kim ND: Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. Int J Mol Med. 33:943–949. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, et al: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res. 68:1303–1309. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, et al: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 475:106–109. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M and Motohashi H: Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell. 22:66–79. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jia Y, Wang H, Wang Q, Ding H, Wu H and Pan H: Silencing Nrf2 impairs glioma cell proliferation via AMPK-activated mTOR inhibition. Biochem Biophys Res Commun. 469:665–671. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu J, Wang H, Chen F, Fu J, Xu Y, Hou Y, Kou HH, Zhai C, Nelson MB, Zhang Q, et al: An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy. Free Radic Biol Med. 99:544–556. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ma B, Zhang H, Wang Y, Zhao A, Zhu Z, Bao X, Sun Y, Li L and Zhang Q: Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. J Exp Clin Cancer Res. 37:2102018. View Article : Google Scholar : PubMed/NCBI | |
|
Woo SM, Seo SU, Min KJ, Im SS, Nam JO, Chang JS, Kim S, Park JW and Kwon TK: Corosolic acid induces non-apoptotic cell death through generation of lipid reactive oxygen species production in human renal carcinoma caki cells. Int J Mol Sci. 19:13092018. View Article : Google Scholar | |
|
Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y and Ling C: Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells. Cancer Lett. 284:229–237. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Takaishi K, Komohara Y, Tashiro H, Ohtake H, Nakagawa T, Katabuchi H and Takeya M: Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation. Cancer Sci. 101:2128–2136. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H, Yamanaka R, Kajiwara K, Saito T, Kuratsu J and Takeya M: M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma. J Clin Exp Hematop. 51:93–99. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Komohara Y, Horlad H, Ohnishi K, Fujiwara Y, Bai B, Nakagawa T, Suzu S, Nakamura H, Kuratsu J and Takeya M: Importance of direct macrophage-tumor cell interaction on progression of human glioma. Cancer Sci. 103:2165–2172. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M and Komohara Y: Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncol Lett. 6:1619–1623. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Fujiwara Y, Komohara Y, Ikeda T and Takeya M: Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Sci. 102:206–211. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cai X, Zhang H, Tong D, Tan Z, Han D, Ji F and Hu W: Corosolic acid triggers mitochondria and caspase-dependent apoptotic cell death in osteosarcoma MG-63 cells. Phytother Res. 25:1354–1361. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jia Y, Yuan H, Shan S, Xu G, Yu J, Zhao C and Mou X: Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncol Lett. 12:4187–4194. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Nho KJ, Chun JM and Kim HK: Corosolic acid induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro. Food Chem Toxicol. 56:8–17. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Bahadori MB, Vandghanooni S, Dinparast L, Eskandani M, Ayatollahi SA, Ata A and Nazemiyeh H: Triterpenoid corosolic acid attenuates HIF-1 stabilization upon cobalt (II) chloride-induced hypoxia in A549 human lung epithelial cancer cells. Fitoterapia. 134:493–500. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang K, Zhu X, Yao Y, Yang M, Zhou F and Zhu L: Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling. Oncol Rep. 39:2777–2786. 2018.PubMed/NCBI | |
|
Fujiwara Y, Takeya M and Komohara Y: A novel strategy for inducing the antitumor effects of triterpenoid compounds: Blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition. Biomed Res Int. 2014:3485392014. View Article : Google Scholar : PubMed/NCBI | |
|
Tseng LM, Huang PI, Chen YR, Chen YC, Chou YC, Chen YW, Chang YL, Hsu HS, Lan YT, Chen KH, et al: Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. J Pharmacol Exp Ther. 341:410–423. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Liu P, Zhang B, Wang A and Yang M: Role of STAT3 decoy oligodeoxynucleotides on cell invasion and chemosensitivity in human epithelial ovarian cancer cells. Cancer Genet Cytogenet. 197:46–53. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Page BD, Ball DP and Gunning PT: Signal transducer and activator of transcription 3 inhibitors: A patent review. Expert Opin Ther Pat. 21:65–83. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lee HS, Park JB, Lee MS, Cha EY, Kim JY and Sul JY: Corosolic acid enhances 5-fluorouracil-induced apoptosis against SNU-620 human gastric carcinoma cells by inhibition of mammalian target of rapamycin. Mol Med Rep. 12:4782–4788. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Park JB, Lee JS, Lee MS, Cha EY, Kim S and Sul JY: Corosolic acid reduces 5-FU chemoresistance in human gastric cancer cells by activating AMPK. Mol Med Rep. 18:2880–2888. 2018.PubMed/NCBI | |
|
Nelson AT, Camelio AM, Claussen KR, Cho J, Tremmel L, Digiovanni J and Siegel D: Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. Bioorg Med Chem Lett. 25:4342–4346. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J and Kunitomo M: Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci. 79:2474–2479. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Chen H, Yang J, Zhang Q, Chen LH and Wang Q: Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-κB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. Circ J. 76:995–1003. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SJ, Cha JY, Kang HS, Lee JH, Ji YL, Park JH, Bae JH, Song DK and Im SS: Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. BMB Rep. 49:276–281. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Festa A, D'Agostino R Jr, Howard G, Mykkänen L, Tracy RP and Haffner SM: Chronic subclinical inflammation as part of the insulin resistance syndrome: The insulin resistance atherosclerosis study (IRAS). Circulation. 102:42–47. 2000. View Article : Google Scholar : PubMed/NCBI |
