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Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma

  • Authors:
    • Yuehua Li
    • Pengfei Li
    • Na Wang
  • View Affiliations / Copyright

    Affiliations: College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi 030024, P.R. China, Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
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    Published online on: December 6, 2020
       https://doi.org/10.3892/ol.2020.12357
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Abstract

The early diagnosis and treatment of liver hepatocellular carcinoma (LIHC) remains a major challenge. Therefore, it is of great significance to strengthen basic research on LIHC in order to improve the prevention and treatment of the disease. Numerous studies have indicated that the PI3K/Akt and FoxO signaling pathways mediate proliferation, survival and migration during the development of LIHC. Therefore, they have become a target for LIHC treatment. Furthermore, let‑7c has been demonstrated to repress cell proliferation, migration and invasion, and to induce G1 phase arrest and apoptosis of LIHC cells. However, the mechanism of its action is not clear. In the present study, the association between let‑7c and the PI3K/Akt/FoxO signaling pathway, as well as their roles in the development of LIHC were investigated using The Cancer Genome Atlas and various public databases (Tumor‑miRNA‑Pathway, OncomiR, DIANA‑TarBase v8, KOBAS 3.0, ONCOMINE, Kaplan‑Meier plotter, LinkedOmics, UALCAN and cBioPortal). The effects of let‑7c‑5p on PI3K/Akt/FoxO signaling pathway‑related target genes were analyzed following overexpression of let‑7c‑5p in the MHCC‑97H cell line via reverse transcription‑quantitative PCR, and the let‑7c‑5p target genes belonging to the PI3K/Akt/FOXO signaling pathway in LIHC were screened out. GO and KEGG enrichment analyses of these target genes was performed using g:Profiler, gOST. In addition, GeneMANIA and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) databases were used to determine the gene‑gene and protein‑protein interaction networks, respectively. The data demonstrated that cyclin B2 (CCNB2), cyclin E2 (CCNE2), cyclin dependent kinase 4 (CDK4), homer scaffold protein 1 (HOMER1), heat shock protein 90 α family class A member 1 (HSP90AA1), neuroblastoma RAS viral oncogene homolog (NRAS), protein phosphatase 2 catalytic subunit α (PPP2CA), protein kinase AMP‑activated catalytic subunit α2 (PRKAA2) and Rac family small GTPase 1 (RAC1) may be target genes of let‑7c‑5p. These genes, particularly CCNE2, were associated with poor overall survival and could be promising candidate biomarkers for disease and poor prognosis in LIHC. Among them, seven genes (CCNE2, CDK4, HSP90AA1, NRAS, PPP2CA, PRKAA2 and RAC1) belonged to the PI3K‑Akt signaling pathway and four genes (CCNB2, HOMER1, NRAS and PRKAA2) belonged to the FoxO signaling pathway. The majority of these genes were closely associated with the cell cycle and their elevated expression may aggravate cell cycle disorders. Therefore, let‑7c may be considered to be an anti‑oncogene of LIHC. The present study may provide novel targets and strategies for the diagnosis and treatment of LIHC.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kim NG, Nguyen PP, Dang H, Kumari R, Garcia G, Esquivel CO and Nguyen MH: Temporal trends in disease presentation and survival of patients with hepatocellular carcinoma: A real-world experience from 1998 to 2015. Cancer. 124:2588–2598. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Krol J, Loedige I and Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 11:597–610. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Huntzinger E and Izaurralde E: Gene silencing by microRNAs: Contributions of translational repression and mRNA decay. Nat Rev Genet. 12:99–110. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Inui M, Martello G and Piccolo S: MicroRNA control of signal transduction. Nat Rev Mol Cell Biol. 11:252–263. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Friedman RC, Farh KK, Burge CB and Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92–105. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Sharma S, Kelly TK and Jones PA: Epigenetics in cancer. Carcinogenesis. 31:27–36. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Ryan BM, Robles AI and Harris CC: Genetic variation in microRNA networks: The implications for cancer research. Nat Rev Cancer. 10:389–402. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Huang S and He X: The role of microRNAs in liver cancer progression. Br J Cancer. 104:235–240. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Gailhouste L and Ochiya T: Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma. Histol Histopathol. 28:437–451. 2013.PubMed/NCBI

12 

Li D, Zhang J and Li J: Role of miRNA sponges in hepatocellular carcinoma. Clin Chim Acta. 500:10–19. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Wang J, Lu L, Luo Z, Li W, Lu Y, Tang Q and Pu J: miR-383 inhibits cell growth and promotes cell apoptosis in hepatocellular carcinoma by targeting IL-17 via STAT3 signaling pathway. Biomed Pharmacother. 120:1095512019. View Article : Google Scholar : PubMed/NCBI

14 

Au SL, Wong CC, Lee JM, Fan DN, Tsang FH, Ng IO and Wong CM: Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology. 56:622–631. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Zhu X, Wu L, Yao J, Jiang H, Wang Q, Yang Z and Wu F: MicroRNA let-7c inhibits cell proliferation and induces cell cycle arrest by targeting CDC25A in human hepatocellular carcinoma. PLoS One. 10:e01242662015. View Article : Google Scholar : PubMed/NCBI

16 

Shimizu S, Takehara T, Hikita H, Kodama T, Miyagi T, Hosui A, Tatsumi T, Ishida H, Noda T, Nagano H, et al: The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol. 52:698–704. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Martini M, De Santis MC, Braccini L, Gulluni F and Hirsch E: PI3K/AKT signaling pathway and cancer: An updated review. Ann Med. 46:372–383. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Guo H, German P, Bai S, Barnes S, Guo W, Qi X, Lou H, Liang J, Jonasch E, Mills GB and Ding Z: The PI3K/AKT Pathway and renal cell carcinoma. J Genet Genomics. 42:343–353. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Faes S and Dormond O: PI3K and AKT: Unfaithful partners in cancer. Int J Mol Sci. 16:21138–21152. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Zhou Q, Lui VW and Yeo W: Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. Future Oncol. 7:1149–1167. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Hou YQ, Yao Y, Bao YL, Song ZB, Yang C, Gao XL, Zhang WJ, Sun LG, Yu CL, Huang YX, et al: Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/Foxo signal pathway in HCC cells. Oxid Med Cell Longev. 2016:49416232016. View Article : Google Scholar : PubMed/NCBI

22 

Wang Q, Yu WN, Chen X, Peng XD, Jeon SM, Birnbaum MJ, Guzman G and Hay N: Spontaneous hepatocellular carcinoma after the combined deletion of Akt isoforms. Cancer Cell. 29:523–535. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Deng M, Bragelmann J, Schultze JL and Perner S: Web-TCGA: An online platform for integrated analysis of molecular cancer data sets. BMC Bioinformatics. 17:722016. View Article : Google Scholar : PubMed/NCBI

24 

Ma Z, Liu T, Huang W, Liu H, Zhang HM, Li Q, Chen Z and Guo AY: MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF-β pathway via targeting SMAD3. Oncotarget. 7:71504–71513. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Wong NW, Chen Y, Chen S and Wang X: OncomiR: An online resource for exploring pan-cancer microRNA dysregulation. Bioinformatics. 34:713–715. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Karagkouni D, Paraskevopoulou MD, Chatzopoulos S, Vlachos IS, Tastsoglou S, Kanellos I, Papadimitriou D, Kavakiotis I, Maniou S, Skoufos G, et al: DIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactions. Nucleic Acids Res. 46:D239–D245. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Ai C and Kong L: CGPS: A machine learning-based approach integrating multiple gene set analysis tools for better prioritization of biologically relevant pathways. J Genet Genomics. 45:489–504. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY and Wei L: KOBAS 2.0: A web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res. 39:W316–W322. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Wu J, Mao X, Cai T, Luo J and Wei L: KOBAS server: A web-based platform for automated annotation and pathway identification. Nucleic Acids Res. 34:W720–W724. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

33 

von Eschenbach AC and Buetow K: Cancer informatics vision: CaBIG. Cancer Inform. 2:22–24. 2007.PubMed/NCBI

34 

Menyhárt O, Nagy Á and Győrffy B: Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 5:1810062018. View Article : Google Scholar : PubMed/NCBI

35 

Nagy A, Lanczky A, Menyhart O and Gyorffy B: Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 8:92272018. View Article : Google Scholar : PubMed/NCBI

36 

Vasaikar SV, Straub P, Wang J and Zhang B: LinkedOmics: Analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 46:D956–D963. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

39 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

42 

The Gene Ontology C: The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Reimand J, Kull M, Peterson H, Hansen J and Vilo J: g:Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res. 35:W193–W200. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Raudvere U, Kolberg L, Kuzmin I, Arak T, Adler P, Peterson H and Vilo J: g:Profiler: A web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res. 47:W191–W198. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38:W214–W220. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Max F, Rodriguez H, Lopes C, Zuberi K, Montojo J, Bader GD and Morris Q: GeneMANIA update 2018. Nuclc Acids Res. 46:W60–W64. 2018. View Article : Google Scholar

47 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43((Database Issue)): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Song Y, Wang F, Huang Q, Cao Y, Zhao Y and Yang C: MicroRNAs contribute to hepatocellular carcinoma. Mini Rev Med Chem. 15:459–466. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Han Y, Liu Y, Fu X, Zhang Q, Huang H, Zhang C, Li W and Zhang J: miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1. J Physiol Biochem. 74:491–501. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Wang Y, Tai Q, Zhang J, Kang J, Gao F, Zhong F, Cai L, Fang F and Gao Y: MiRNA-206 inhibits hepatocellular carcinoma cell proliferation and migration but promotes apoptosis by modulating cMET expression. Acta Biochim Biophys Sin (Shanghai). 51:243–253. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Zhu XM, Wu LJ, Xu J, Yang R and Wu FS: Let-7c microRNA expression and clinical significance in hepatocellular carcinoma. J Int Med Res. 39:2323–2329. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Jilek JL, Zhang QY, Tu MJ, Ho PY, Duan Z, Qiu JX and Yu AM: Bioengineered Let-7c inhibits orthotopic hepatocellular carcinoma and improves overall survival with minimal immunogenicity. Mol Ther Nucleic Acids. 14:498–508. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Luo H, Hao E, Tan D, Wei W, Xie J, Feng X, Du Z, Huang C, Bai G, Hou Y, et al: Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway. Food Chem Toxicol. 134:1108612019. View Article : Google Scholar : PubMed/NCBI

55 

Farhan M, Wang H, Gaur U, Little PJ, Xu J and Zheng W: FOXO signaling pathways as therapeutic targets in cancer. Int J Biol Sci. 13:815–827. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Nam HJ and van Deursen JM: Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol. 16:538–549. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Zhang Q, Sun S, Zhu C, Zheng Y, Cai Q, Liang X, Xie H and Zhou J: Prediction and analysis of weighted genes in hepatocellular carcinoma using bioinformatics analysis. Mol Med Rep. 19:2479–2488. 2019.PubMed/NCBI

58 

Lauper N, Beck AR, Cariou S, Richman L, Hofmann K, Reith W, Slingerland JM and Amati B: Cyclin E2: A novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 17:2637–2643. 1998. View Article : Google Scholar : PubMed/NCBI

59 

Hwang HC and Clurman BE: Cyclin E in normal and neoplastic cell cycles. Oncogene. 24:2776–2786. 2005. View Article : Google Scholar : PubMed/NCBI

60 

Caldon CE and Musgrove EA: Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. Cell Div. 5:22010. View Article : Google Scholar : PubMed/NCBI

61 

Sherr CJ, Beach D and Shapiro GI: Targeting CDK4 and CDK6: From discovery to therapy. Cancer Discov. 6:353–367. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Xiang X, You XM and Li LQ: Expression of HSP90AA1/HSPA8 in hepatocellular carcinoma patients with depression. Onco Targets Ther. 11:3013–3023. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Piredda ML, Gaur G, Catalano G, Divona M, Banella C, Travaglini S, Puzzangara MC, Voso MT, Lo-Coco F and Noguera NI: PML/RARA inhibits expression of HSP90 and its target AKT. Br J Haematol. 184:937–948. 2019.PubMed/NCBI

64 

Hou C, Li Y, Liu H, Dang M, Qin G, Zhang N and Chen R: Profiling the interactome of protein kinase C zeta by proteomics and bioinformatics. Proteome Sci. 16:52018. View Article : Google Scholar : PubMed/NCBI

65 

Fox MM, Phoenix KN, Kopsiaftis SG and Claffey KP: AMP-activated protein kinase alpha 2 isoform suppression in primary breast cancer alters AMPK growth control and apoptotic signaling. Genes Cancer. 4:3–14. 2013. View Article : Google Scholar : PubMed/NCBI

66 

Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, González-Billalabeitia E, Hung MC, et al: A UBE2O-AMPKα2 axis that promotes tumor initiation and progression offers opportunities for therapy. Cancer Cell. 31:208–224. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Jardin I, Albarran L, Bermejo N, Salido GM and Rosado JA: Homers regulate calcium entry and aggregation in human platelets: A role for Homers in the association between STIM1 and Orai1. Biochem J. 445:29–38. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Moccia F, Zuccolo E, Poletto V, Turin I, Guerra G, Pedrazzoli P, Rosti V, Porta C and Montagna D: Targeting stim and orai proteins as an alternative approach in anticancer therapy. Curr Med Chem. 23:3450–3480. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Rajalingam K, Schreck R, Rapp UR and Albert S: Ras oncogenes and their downstream targets. Biochim Biophys Acta. 1773:1177–1195. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Dietrich P, Gaza A, Wormser L, Fritz V, Hellerbrand C and Bosserhoff AK: Neuroblastoma RAS viral oncogene homolog (NRAS) is a novel prognostic marker and contributes to sorafenib resistance in hepatocellular carcinoma. Neoplasia. 21:257–268. 2019. View Article : Google Scholar : PubMed/NCBI

71 

Xiang RF, Stack D, Huston SM, Li SS, Ogbomo H, Kyei SK and Mody CH: Ras-related C3 botulinum toxin substrate (Rac) and Src Family Kinases (SFK) Are proximal and essential for phosphatidylinositol 3-Kinase (PI3K) activation in natural Killer (NK) Cell-mediated Direct Cytotoxicity against cryptococcus neoformans. J Biol Chem. 291:6912–6922. 2016. View Article : Google Scholar : PubMed/NCBI

72 

Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, et al: CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest. 120:1178–1191. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, Li Y, Cui HY, Guo YS, Tavernier J, et al: HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology. 54:2012–2024. 2011. View Article : Google Scholar : PubMed/NCBI

74 

Ran RZ, Chen J, Cui LJ, Lin XL, Fan MM, Cong ZZ, Zhang H, Tan WF, Zhang GQ and Zhang YJ: miR-194 inhibits liver cancer stem cell expansion by regulating RAC1 pathway. Exp Cell Res. 378:66–75. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Li P and Wang N: Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. Oncol Lett 21: 96, 2021.
APA
Li, Y., Li, P., & Wang, N. (2021). Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. Oncology Letters, 21, 96. https://doi.org/10.3892/ol.2020.12357
MLA
Li, Y., Li, P., Wang, N."Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma". Oncology Letters 21.2 (2021): 96.
Chicago
Li, Y., Li, P., Wang, N."Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma". Oncology Letters 21, no. 2 (2021): 96. https://doi.org/10.3892/ol.2020.12357
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li P and Wang N: Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. Oncol Lett 21: 96, 2021.
APA
Li, Y., Li, P., & Wang, N. (2021). Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. Oncology Letters, 21, 96. https://doi.org/10.3892/ol.2020.12357
MLA
Li, Y., Li, P., Wang, N."Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma". Oncology Letters 21.2 (2021): 96.
Chicago
Li, Y., Li, P., Wang, N."Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma". Oncology Letters 21, no. 2 (2021): 96. https://doi.org/10.3892/ol.2020.12357
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