Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis

  • Authors:
    • Yuanhua Nie
    • Zhiqiang Zhao
    • Minxue Chen
    • Fulin Ma
    • Yong Fan
    • Yingxin Kang
    • Boxiong Kang
    • Chen Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China
    Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 107
    |
    Published online on: December 10, 2020
       https://doi.org/10.3892/ol.2020.12368
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription‑quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pancreatic cancer. Gene expression of ANLN in normal and cancer tissues was analyzed using data from The Cancer Genome Atlas, Oncomine and Gene Expression database of Normal and Tumor tissues 2 and ANOVA, and the association between ANLN mRNA expression and ANLN genovariation was analyzed using cBioPortal. The association between ANLN expression and the survival, clinical, pathological and prognostic characteristics of PC was analyzed using Kaplan‑Meier (K‑M) survival analysis, Kruskal Wallis and Mann Whitney‑U tests, and logistic and Cox regression models. Gene Set Enrichment Analysis (GSEA) revealed the molecular pathways underpinning ANLN function in PC. Overexpression of ANLN was observed in PC cells (normal vs. tumor, P<0.01) and tissues (normal vs. tumor, P=0.008). Enhanced ANLN expression was associated with high tumor grade (grade 1 vs. grade 3, odds ratio: 5.662, P<0.001). However, ANLN expression was not associated with other clinical features (all P>0.05). K‑M analysis suggested that increased ANLN expression was associated with poor survival (P=0.002). Univariate and multivariate analysis revealed the ANLN is an independent prognostic factor for PC (P<0.001). GSEA demonstrated the p53, cell cycle, DNA replication, mismatch repair, nucleotide excision repair and PC pathways were associated with low expression of ANLN. Overall, ANLN is more highly expressed in PC compared with in normal tissue, and is associated with poor differentiation. The expression of ANLN may be a novel prognostic marker of poor survival. Finally, ANLN exert its functions in PC through the p53, cell cycle, DNA replication, mismatch repair and nucleotide excision repair and pathways.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG and McCain RS: Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI

3 

American Cancer Society, . Cancer Facts & Figures 2020. American Cancer Society, Inc.; Atlanta, GA: 2020, simplehttps://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2020.htmlFebruary. 2020

4 

Mizrahi JD, Surana R, Valle JW and Shroff RT: Pancreatic cancer. Lancet. 395:2008–2020. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Avgerinos DV and Björnsson J: Malignant neoplasms: Discordance between clinical diagnoses and autopsy findings in 3,118 cases. Apmis. 109:774–780. 2010. View Article : Google Scholar

6 

Bosetti C, Bertuccio P, Negri E, La Vecchia CL, Zeegers MP and Boffetta P: Pancreatic cancer: Overview of descriptive epidemiology. Mol Carcinog. 51:3–13. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Lambe M, Eloranta S, Wigertz A and Blomqvist P: Pancreatic cancer; reporting and long-term survival in Sweden. Acta Oncol. 50:1220–1227. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Oberstein PE and Olive KP: Pancreatic cancer: Why is it so hard to treat? Therap Adv Gastroenterol. 6:321–337. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Sens MA, Zhou XD, Weiland T and Cooley AM: Unexpected neoplasia in autopsies: Potential implications for tissue and organ safety. Arch Pathol Lab Med. 133:1923–1931. 2009.PubMed/NCBI

10 

Uzunparmak B and Sahin IH: Pancreatic cancer microenvironment: A current dilemma. Clin Transl Med. 8:2019. View Article : Google Scholar : PubMed/NCBI

11 

Field CM and Alberts BM: Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex. J Cell Biol. 131:165–178. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Oegema K, Savoian MS, Mitchison TJ and Field CM: Functional analysis of a human homologue of the drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 150:539–552. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Gould GW: Animal cell cytokinesis: The role of dynamic changes in the plasma membrane proteome and lipidome. Semin Cell Dev Biol. 53:64–73. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Goyal A, Takaine M, Simanis V and Nakano K: Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis. Cytoskeleton (Hoboken). 68:69–88. 2011. View Article : Google Scholar : PubMed/NCBI

15 

D'Avino PP: How to scaffold the contractile ring for a safe cytokinesis-lessons from Anillin-related proteins. J Cell Sci. 122:1071–1079. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Song K, Russo G and Krauss M: Septins as modulators of endo-lysosomal membrane traffic. Front Cell Dev Biol. 4:1242016. View Article : Google Scholar : PubMed/NCBI

17 

Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, Tsuchiya E and Nakamura Y: ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 65:11314–11325. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Wang G, Shen W, Cui L, Chen W, Hu X and Fu J: Overexpression of Anillin (ANLN) is correlated with colorectal cancer progression and poor prognosis. Cancer Biomark. 16:459–465. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zeng S, Yu X, Ma C, Song R, Zhang Z, Zi X, Chen X, Wang Y, Yu Y, Zhao J, et al: Transcriptome sequencing identifies ANLN as a promising prognostic biomarker in bladder urothelial carcinoma. Sci Rep. 7:31512017. View Article : Google Scholar : PubMed/NCBI

20 

Olakowski M, Tyszkiewicz T, Jarzab M, Król R, Oczko-Wojciechowska M, Kowalska M, Kowal M, Gala GM, Kajor M, Lange D, et al: NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma. Folia Histochem Cytobiol. 47:249–255. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Wang Z, Chen J, Zhong MZ, Huang J, Hu YP, Feng DY, Zhou ZJ, Luo X, Liu ZQ, Jiang WZ and Zhou WB: Overexpression of ANLN contributed to poor prognosis of anthracycline-based chemotherapy in breast cancer patients. Cancer Chemother Pharmacol. 79:535–543. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Tamura K, Furihata M, Tsunoda T, Ashida S, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, et al: Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. Cancer Res. 67:5117–5125. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Park SJ, Yoon BH, Kim SK and Kim SY: GENT2: An updated gene expression database for normal and tumor tissues. BMC Med Genomics. 12 (Suppl 5):1012019. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Team R: RStudio: Integrated Development for R, 2015. RStudio, Inc.; Boston, MA: 2015, simplehttp://www.rstudio.comPubMed/NCBI

26 

Long X, Zhou W, Wang Y and Liu S: Prognostic significance of ANLN in lung adenocarcinoma. Oncol Lett. 16:1835–1840. 2018.PubMed/NCBI

27 

Sadi AM, Wang DY, Youngson BJ, Miller N, Boerner S, Done SJ and Leong WL: Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens. Bmc Cancer. 11:2532011. View Article : Google Scholar : PubMed/NCBI

28 

Wang S, Mo Y, Midorikawa K, Zhang Z, Huang G, Ma N, Zhao W, Hiraku Y, Oikawa S and Murata M: The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L. Oncotarget. 6:35893–35907. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Weinberger P, Ponny SR, Xu H, Bai S, Smallridge R, Copland J and Sharma A: Cell Cycle M-Phase genes are highly upregulated in anaplastic thyroid carcinoma. Thyroid. 27:236–252. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Xia L, Su X, Shen J, Meng Q, Yan J, Zhang C, Chen Y, Wang H and Xu M: ANLN functions as a key candidate gene in cervical cancer as determined by integrated bioinformatic analysis. Cancer Manag Res. 10:663–670. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Wang A, Dai H, Gong Y, Zhang C, Shu J, Luo Y, Jiang Y, Liu W and Bie P: ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis. J Exp Clin Cancer Res. 38:3472019. View Article : Google Scholar : PubMed/NCBI

32 

Zeng S: The mechanism of ANLN in the carcinogenesis of bladder cancer. PhD dissertationChinese People's Liberation Army Naval Medical University Shanghai 211 Engineering College, Shanghai, China2017.

33 

Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N, Bian Z, Gu S, Xu M, et al: m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma. Mol Cancer. 18:1882019. View Article : Google Scholar : PubMed/NCBI

34 

Ghoshal K, Majumder S, Li Z, Dong X and Jacob ST: Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylation. J Biol Chem. 275:539–547. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Nigg EA: Mitotic kinases as regulators of cell division and its checkpoints. 2:21–32. 2001.

36 

Kiyomitsu T and Cheeseman IM: Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Cell. 154:391–402. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Brinkley BR: Managing the centrosome numbers game: From chaos to stability in cancer cell division. Trends Cell Biol. 11:18–21. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nie Y, Zhao Z, Chen M, Ma F, Fan Y, Kang Y, Kang B and Wang C: Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis. Oncol Lett 21: 107, 2021.
APA
Nie, Y., Zhao, Z., Chen, M., Ma, F., Fan, Y., Kang, Y. ... Wang, C. (2021). Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis. Oncology Letters, 21, 107. https://doi.org/10.3892/ol.2020.12368
MLA
Nie, Y., Zhao, Z., Chen, M., Ma, F., Fan, Y., Kang, Y., Kang, B., Wang, C."Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis". Oncology Letters 21.2 (2021): 107.
Chicago
Nie, Y., Zhao, Z., Chen, M., Ma, F., Fan, Y., Kang, Y., Kang, B., Wang, C."Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis". Oncology Letters 21, no. 2 (2021): 107. https://doi.org/10.3892/ol.2020.12368
Copy and paste a formatted citation
x
Spandidos Publications style
Nie Y, Zhao Z, Chen M, Ma F, Fan Y, Kang Y, Kang B and Wang C: Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis. Oncol Lett 21: 107, 2021.
APA
Nie, Y., Zhao, Z., Chen, M., Ma, F., Fan, Y., Kang, Y. ... Wang, C. (2021). Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis. Oncology Letters, 21, 107. https://doi.org/10.3892/ol.2020.12368
MLA
Nie, Y., Zhao, Z., Chen, M., Ma, F., Fan, Y., Kang, Y., Kang, B., Wang, C."Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis". Oncology Letters 21.2 (2021): 107.
Chicago
Nie, Y., Zhao, Z., Chen, M., Ma, F., Fan, Y., Kang, Y., Kang, B., Wang, C."Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis". Oncology Letters 21, no. 2 (2021): 107. https://doi.org/10.3892/ol.2020.12368
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team