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Article Open Access

Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer

  • Authors:
    • Qianshi Zhang
    • Zhen Feng
    • Shasha Shi
    • Yu Zhang
    • Shuangyi Ren
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 144
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    Published online on: December 21, 2020
       https://doi.org/10.3892/ol.2020.12405
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Abstract

Although accumulating evidence has confirmed the potential biological functions of long non‑coding RNAs (lncRNAs) as competitive endogenous RNAs (ceRNAs) in colorectal tumorigenesis and progression, few studies have focused on rectosigmoid junction cancer. In the present study, a comprehensive analysis was conducted to explore lncRNA‑mediated ceRNA implications and their potential value for prognosis. lncRNA, microRNA (miR/miRNA) and mRNA expression profiles were downloaded from The Cancer Genome Atlas database. Subsequently, a lncRNA‑miRNA‑mRNA regulatory network was constructed to evaluate the functions of these differentially expressed genes on overall survival (OS) for rectosigmoid junction cancer. As a result, a rectosigmoid junction cancer‑specific ceRNA network was successfully constructed with 7 differentially expressed (DE)lncRNAs, 16 DEmiRNAs and 71 DEmRNAs. Among the network, one DElncRNA (small nucleolar RNA host gene 20) and three mRNAs (sodium‑ and chloride‑dependent taurine transporter, fibroblast growth factor 13 and tubulin polyglutamylase TTLL7) were significantly associated with OS (P<0.05). Additionally, two lncRNAs (KCNQ1OT1 and MIR17HG) interacted with most of the DEmiRNAs. Notably, two top‑ranked miRNAs (hsa‑miR‑374a‑5p and hsa‑miR‑374b‑5p) associated networks were identified to be markedly associated with the pathogenesis. Furthermore, four DEmRNAs (caveolin‑1, MET, filamin‑A and AKT3) were enriched in the Kyoto Encylopedia of Gene and Genomes pathway analysis, as well as being included in the ceRNA network. In summary, the present results revealed that a specific lncRNA‑miRNA‑mRNA network was associated with rectosigmoid junction cancer, providing several molecules that may be used as novel prognostic biomarkers and therapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Feng Z, Shi S, Zhang Y and Ren S: Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer. Oncol Lett 21: 144, 2021.
APA
Zhang, Q., Feng, Z., Shi, S., Zhang, Y., & Ren, S. (2021). Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer. Oncology Letters, 21, 144. https://doi.org/10.3892/ol.2020.12405
MLA
Zhang, Q., Feng, Z., Shi, S., Zhang, Y., Ren, S."Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer". Oncology Letters 21.2 (2021): 144.
Chicago
Zhang, Q., Feng, Z., Shi, S., Zhang, Y., Ren, S."Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer". Oncology Letters 21, no. 2 (2021): 144. https://doi.org/10.3892/ol.2020.12405
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Feng Z, Shi S, Zhang Y and Ren S: Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer. Oncol Lett 21: 144, 2021.
APA
Zhang, Q., Feng, Z., Shi, S., Zhang, Y., & Ren, S. (2021). Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer. Oncology Letters, 21, 144. https://doi.org/10.3892/ol.2020.12405
MLA
Zhang, Q., Feng, Z., Shi, S., Zhang, Y., Ren, S."Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer". Oncology Letters 21.2 (2021): 144.
Chicago
Zhang, Q., Feng, Z., Shi, S., Zhang, Y., Ren, S."Comprehensive analysis of lncRNA‑associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer". Oncology Letters 21, no. 2 (2021): 144. https://doi.org/10.3892/ol.2020.12405
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