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PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer

  • Authors:
    • Masahiro Shimomura
    • Takeshi Fukuda
    • Yuichiro Awazu
    • Shigenori Nanno
    • Yuta Inoue
    • Hiroaki Matsubara
    • Makoto Yamauchi
    • Tomoyo Yasui
    • Toshiyuki Sumi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
    Copyright: © Shimomura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 150
    |
    Published online on: December 24, 2020
       https://doi.org/10.3892/ol.2020.12411
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Abstract

The standard care for patients with locally advanced cervical cancer is concurrent chemoradiotherapy. Successful neoadjuvant chemotherapy (NAC) can reduce tumor size and enable patients to be eligible for a hysterectomy, which can improve their prognosis. Selecting the right candidate for NAC is important since NAC failure results in switching to radiation therapy and can lead to a worse prognosis due to a delay in the initiation of the core therapy. Therefore, the identification of biomarkers that can predict the effect of NAC is essential. Previous reports have suggested a relationship between protein arginine methyltransferase (PRMT1) and chemoresistance in several types of cancer. PRMT1 has been demonstrated to methylate apoptosis signal‑regulated kinase 1 and to inhibit its activity, thereby contributing to chemoresistance. The present study investigated the association between PRMT1 expression and the efficacy of NAC in locally advanced cervical cancer. Data from 53 patients with locally advanced uterine cervical cancer who were classified into two groups based on effective (n=28) and ineffective (n=25) responses to NAC treatment were evaluated. PRMT1 expression was investigated by immunohistochemistry and scored using a weighted scoring system. Additionally, the present study investigated the effect of RNA interference‑mediated downregulation of PRMT1 on the sensitivity of cervical cancer cells to cisplatin in vitro. The results demonstrated that the NAC effective group had significantly lower weighted PRMT1 scores than the NAC ineffective group (P=0.030). In addition, lower tumor expression levels of PRMT1 were significantly associated with increased sensitivity to NAC (P=0.033). Furthermore, downregulation of PRMT1 expression in cervical cancer cells markedly improved their sensitivity to cisplatin in vitro. The present study suggested that PRMT1 expression has potential as a predictive marker of the efficacy of NAC in patients with locally advanced cervical cancer. This finding can contribute to improvements in the prognosis of these patients.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2011. View Article : Google Scholar

2 

Pecorelli S: Revised FIGO staging for carcinoma of the vulva, cervix and endometrium. Int J Gynaecol Obstet. 105:103–104. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Japan Society of Gynecologic Oncology (eds), . Formulation Committee of the Treatment Guidelines for Cervical Cancer, 2011. Kanehara & Co.; Tokyo: 2011, (In Japanese).

4 

National Comprehensive Cancer Network, . NCCN Clinical Practice Guidelines in Oncology. Cervical Cancer Version II. 2013.simplehttps://www2.tri-kobe.org/nccn/guideline/gynecological/english/cervical.pdf

5 

Morris M, Eifel PJ, Lu J, Grigsby PW, Levenback C, Stevens RE, Rotman M, Gershenson DM and Mutch DG: Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med. 340:1137–1143. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Eifel PJ, Winter K, Morris M, Levenback C, Grigsby PW, Cooper J, Rotman M, Gershenson D and Mutch DG: Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: An update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol. 22:872–880. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Ishiko O, Sumi T, Yasui T, Matsumoto Y, Kawamura N, Ogita S, Kamino T, Nakamura K and Yamada R: Balloon-occluded arterial infusion chemotherapy, simple total hysterectomy and radiotherapy as a useful combination-therapy for advanced cancer of the uterine cervix. Oncol Rep. 7:141–144. 2000.PubMed/NCBI

8 

Souhami L, Gil RA, Allan SE, Canary PC, Araújo CM, Pinto LH and Silveira TR: A randomized trial of chemotherapy followed by pelvic radiation therapy in stage IIIB carcinoma of the cervix. J Clin Oncol. 9:970–977. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Tattersall MH, Lorvidhaya V, Vootiprux V, Cheirsilpa A, Wong F, Azhar T, Lee HP, Kang SB, Manalo A, Yen MS, et al: Randomized trial of epirubicin and cisplatin chemotherapy followed by pelvic radiation in locally advanced cervical cancer. Cervical cancer study group of the asian oceanian clinical oncology association. J Clin Oncol. 13:444–451. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Ishiko O, Sumi T, Yasui T, Matsumoto Y, Ogita S, Kaminou T, Nakamura K and Yamada R: Tumor marker and MR imaging criteria for evaluating the efficacy of cyclic balloon-occluded arterial infusion for advanced cancer of the uterine cervix. Oncol Rep. 7:827–830. 2000.PubMed/NCBI

11 

Ishiko O, Sumi T, Yoshida H, Ogita S and Yamada R: Expression of apoptosis regulatory proteins in advanced cancer of the uterine cervix after cyclic balloon-occluded arterial infusion chemotherapy. Int J Oncol. 18:1151–1155. 2001.PubMed/NCBI

12 

Okamoto E, Sumi T, Misugi F, Nobeyama H, Hattori K, Yoshida H, Matsumoto Y, Yasui T, Honda K and Ishiko O: Expression of apoptosis-related proteins in advanced uterine cervical cancer after balloon-occluded arterial infusion chemotherapy as an indicator of the efficiency of this therapy. Int J Mol Med. 15:41–47. 2005.PubMed/NCBI

13 

Nobeyama H, Sumi T, Misugi F, Okamoto E, Hattori K, Matsumoto Y, Yasui T, Honda K, Iwai K and Ishiko O: Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer. Int J Mol Med. 14:101–105. 2004.PubMed/NCBI

14 

Benedetti Panici P, Bellati F, Manci N, Pernice M, Plotti F, Di Donato V, Calcagno M, Zullo MA, Muzii L and Angioli R: Neoadjuvant chemotherapy followed by radical surgery in patients affected by FIGO stage IVA cervical cancer. Ann Surg Oncol. 14:2643–2648. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Siddik ZH: Cisplatin: Mode of cytotoxic action and molecular basis of resistance. Oncogene. 22:7265–7279. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Wang Q, Shi S, He W, Padilla MT, Zhang L, Wang X, Zhang B and Lin Y: Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. Oncotarget. 5:1304–1314. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Bedford MT and Richard S: Arginine methylation an emerging regulator of protein function. Mol Cell. 18:263–72. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Baldwin RM, Morettin A and Côté J: Role of PRMTs in cancer: Could minor isoforms be leaving a mark? World J Biol Chem. 5:115–129. 2014.PubMed/NCBI

19 

Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T, Naguro I, Kano K, Udagawa T, Natsume T, et al: TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1-negative regulator PRMT1. Cell Rep. 21:2447–2457. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, et al: PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 125:4529–4543. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zhao Y, Lu Q, Li C, Wang X, Jiang L, Huang L, Wang C and Chen H: PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation. Cell Death Dis. 10:3592019. View Article : Google Scholar : PubMed/NCBI

22 

Tsuji K, Yamada R, Kawabata M, Mitsuzane K, Sato M, Iwahashi M, Kitayama S and Nakano R: Effect of balloon occluded arterial infusion of anticancer drugs on the prognosis of cervical cancer treated with radiation therapy. Int J Radiat Oncol Biol Phys. 32:1337–1345. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Sinicrope FA, Ruan SB, Cleary KR, Stephens LC, Lee JJ and Levin B: Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 55:237–241. 1995.PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Cho JH, Lee MK, Yoon KW, Lee J, Cho SG and Choi EJ: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1. Cell Death Differ. 19:859–870. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shimomura M, Fukuda T, Awazu Y, Nanno S, Inoue Y, Matsubara H, Yamauchi M, Yasui T and Sumi T: PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer. Oncol Lett 21: 150, 2021.
APA
Shimomura, M., Fukuda, T., Awazu, Y., Nanno, S., Inoue, Y., Matsubara, H. ... Sumi, T. (2021). PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer. Oncology Letters, 21, 150. https://doi.org/10.3892/ol.2020.12411
MLA
Shimomura, M., Fukuda, T., Awazu, Y., Nanno, S., Inoue, Y., Matsubara, H., Yamauchi, M., Yasui, T., Sumi, T."PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer". Oncology Letters 21.2 (2021): 150.
Chicago
Shimomura, M., Fukuda, T., Awazu, Y., Nanno, S., Inoue, Y., Matsubara, H., Yamauchi, M., Yasui, T., Sumi, T."PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer". Oncology Letters 21, no. 2 (2021): 150. https://doi.org/10.3892/ol.2020.12411
Copy and paste a formatted citation
x
Spandidos Publications style
Shimomura M, Fukuda T, Awazu Y, Nanno S, Inoue Y, Matsubara H, Yamauchi M, Yasui T and Sumi T: PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer. Oncol Lett 21: 150, 2021.
APA
Shimomura, M., Fukuda, T., Awazu, Y., Nanno, S., Inoue, Y., Matsubara, H. ... Sumi, T. (2021). PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer. Oncology Letters, 21, 150. https://doi.org/10.3892/ol.2020.12411
MLA
Shimomura, M., Fukuda, T., Awazu, Y., Nanno, S., Inoue, Y., Matsubara, H., Yamauchi, M., Yasui, T., Sumi, T."PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer". Oncology Letters 21.2 (2021): 150.
Chicago
Shimomura, M., Fukuda, T., Awazu, Y., Nanno, S., Inoue, Y., Matsubara, H., Yamauchi, M., Yasui, T., Sumi, T."PRMT1 expression predicts response to neoadjuvant chemotherapy for locally advanced uterine cervical cancer". Oncology Letters 21, no. 2 (2021): 150. https://doi.org/10.3892/ol.2020.12411
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