Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma

  • Authors:
    • Yu Saito
    • Satoru Imura
    • Yuji Morine
    • Tetsuya Ikemoto
    • Shinichiro Yamada
    • Mitsuo Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokushima University, Tokushima 770‑8503, Japan
  • Article Number: 153
    |
    Published online on: December 31, 2020
       https://doi.org/10.3892/ol.2020.12414
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prognostic nutritional index (PNI) is one of the immune parameters calculated on the basis of the serum albumin and the total lymphocyte count. The aim of the present study was to investigate the prognostic significance of the PNI for short‑ and long‑term outcomes after liver resection for patients with hepatocellular carcinoma (HCC). Data from 162 surgically treated patients with HCC (without any previous treatment) were retrospectively analyzed. The cutoff value of preoperative PNI was 45.0, which was calculated by a receiver operating characteristic curve for predicting the recurrence of HCC after liver resection. Patients were divided into low (n=86) and high (n=76) PNI groups. In short‑term outcomes, patients in the low PNI group were more likely to experience postoperative complications compared with those in the high PNI group. The 5‑year disease‑free survival (DFS) rate in the low PNI group was significantly lower compared with that in the high PNI group (20.5% vs. 48.7%). In the multivariate analysis, a low PNI was an independent prognostic factor for DFS (HR, 1.65; 95% CI, 1.00‑2.71). In conclusion, the preoperative PNI may be a prognostic factor for evaluating short‑ and long‑term outcomes after liver resection in patients with HCC.
View Figures

Figure 1

Figure 2

View References

1 

Villanueva A: Hepatocellular Carcinoma. N Engl J Med. 380:1450–1462. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Maehara Y, Nishie A and Yamanaka T: Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 100:1523–1530. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Voron T, Tselikas L, Pietrasz D, Pigneur F, Laurent A, Compagnon P, Salloum C, Luciani A and Azoulay D: Sarcopenia impacts on short- and long-term results of hepatectomy for hepatocellular carcinoma. Ann Surg. 261:1173–1183. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Okuda Y, Taura K, Yoshino K, Ikeno Y, Nishio T, Yamamoto G, Tanabe K, Koyama Y, Hatano E, Tanaka S and Uemoto S: Usefulness of Mac-2 binding protein glycosylation isomer for prediction of posthepatectomy liver failure in patients with hepatocellular carcinoma. Ann Surg. 265:1201–1208. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Buzby GP, Mullen JL, Matthews DC, Hobbs CL and Rosato EF: Prognostic nutritional index in gastrointestinal surgery. Am J Surg. 139:160–167. 1980. View Article : Google Scholar : PubMed/NCBI

6 

Onodera T, Goseki N and Kosaki G: Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai Zasshi. 85:1001–1005. 1984.(In Japanese). PubMed/NCBI

7 

Okada S, Shimada J, Kato D, Tsunezuka H, Teramukai S and Inoue M: Clinical significance of prognostic nutritional index after surgical treatment in lung cancer. Ann Thorac Surg. 104:296–302. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Miao Y, Li S, Yan Q, Li B and Feng Y: Prognostic significance of preoperative prognostic nutritional index in epithelial ovarian cancer patients treated with platinum-based chemotherapy. Oncol Res Treat. 39:712–719. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Haraga J, Nakamura K, Omichi C, Nishida T, Haruma T, Kusumoto T, Seki N, Masuyama H, Katayama N, Kanazawa S and Hiramatsu Y: Pretreatment prognostic nutritional index is a significant predictor of prognosis in patients with cervical cancer treated with concurrent chemoradiotherapy. Mol Clin Oncol. 5:567–574. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Han WX, Chen ZM, Wei ZJ and Xu AM: Preoperative pre-albumin predicts prognosis of patients after gastrectomy for adenocarcinoma of esophagogastric junction. World J Surg Oncol. 14:2792016. View Article : Google Scholar : PubMed/NCBI

11 

Yang Y, Gao P, Chen X, Song Y, Shi J, Zhao J, Sun J, Xu Y and Wang Z: Prognostic significance of preoperative prognostic nutritional index in colorectal cancer: Results from a retrospective cohort study and a meta-analysis. Oncotarget. 7:58543–58552. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Ke M, Xu T, Li N, Ren Y, Shi A, Lv Y and He H: Prognostic nutritional index predicts short-term outcomes after liver resection for hepatocellular carcinoma within the Milan criteria. Oncotarget. 7:81611–81620. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Chan AW, Chan SL, Wong GL, Wong VW, Chong CC, Lai PB, Chan HL and To KF: Prognostic nutritional index (pni) predicts tumor recurrence of very early/early stage hepatocellular carcinoma after surgical resection. Ann Surg Oncol. 22:4138–4148. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Yamada S, Shimada M, Morine Y, Imura S, Ikemoto T, Arakawa Y, Saito Y, Yoshikawa M and Miyazaki K: Significance of frailty in prognosis after hepatectomy for elderly patients with hepatocellular carcinoma. Ann Surg Oncol. Jun 19–2020.(Epub ahead of print).

15 

Yamada S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Saito Y, Yoshikawa M, Miyazaki K and Shimada M: Prognostic prediction of apparent diffusion coefficient obtained by diffusion-weighted MRI in mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 27:388–395. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D and Durand F: The ‘50–50 criteria’ on postoperative day 5: An accurate predictor of liver failure and death after hepatectomy. Ann Surg. 242:824–829. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Ji F, Liang Y, Fu S, Chen D, Cai X, Li S, Peng B, Liang L and Hua Y: Prognostic value of combined preoperative prognostic nutritional index and body mass index in HCC after hepatectomy. HPB (Oxford). 19:695–705. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Peng W, Li C, Wen TF, Yan LN, Li B, Wang WT, Yang JY and Xu MQ: Postoperative prognostic nutritional index change is an independent predictor of survival in patients with small hepatocellular carcinoma. Am J Surg. 212:122–127. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Man Z, Pang Q, Zhou L, Wang Y, Hu X, Yang S, Jin H and Liu H: Prognostic significance of preoperative prognostic nutritional index in hepatocellular carcinoma: A meta-analysis. HPB (Oxford). 20:888–895. 2018. View Article : Google Scholar : PubMed/NCBI

20 

He CB and Lin XJ: Inflammation scores predict the survival of patients with hepatocellular carcinoma who were treated with transarterial chemoembolization and recombinant human type-5 adenovirus H101. PLoS One. 12:e01747692017. View Article : Google Scholar : PubMed/NCBI

21 

Taussig MD, Irene Koran ME, Mouli SK, Ahmad A, Geevarghese S, Baker JC, Lipnik AJ, Banovac F and Brown DB: Neutrophil to lymphocyte ratio predicts disease progression following intra-arterial therapy of hepatocellular carcinoma. HPB (Oxford). 19:458–464. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Shirabe K, Mano Y, Muto J, Matono R, Motomura T, Toshima T, Takeishi K, Uchiyama H, Yoshizumi T, Taketomi A, et al: Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. Surg Today. 42:1–7. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Harimoto N, Shirabe K, Nakagawara H, Toshima T, Yamashita Y, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T and Maehara Y: Prognostic factors affecting survival at recurrence of hepatocellular carcinoma after living-donor liver transplantation: With special reference to neutrophil/lymphocyte ratio. Transplantation. 96:1008–1012. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Peng W, Li C, Wen TF, Yan LN, Li B, Wang WT, Yang JY and Xu MQ: Neutrophil to lymphocyte ratio changes predict small hepatocellular carcinoma survival. J Surg Res. 192:402–408. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Koike Y, Miki C, Okugawa Y, Yokoe T, Toiyama Y, Tanaka K, Inoue Y and Kusunoki M: Preoperative C-reactive protein as a prognostic and therapeutic marker for colorectal cancer. J Surg Oncol. 98:540–544. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Okugawa Y, Toiyama Y, Yamamoto A, Shigemori T, Ide S, Kitajima T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, et al: Lymphocyte-C-reactive protein ratio as promising new marker for predicting surgical and oncological outcomes in colorectal cancer. Ann Surg. Aug;2019.(Epub ahead of print).

27 

Ohtani H, Mori K, Nakajima M and Hamaichi U: Defining lymphocyte-predominant breast cancer by the proportion of lymphocyte-rich stroma and its significance in routine histopathological diagnosis. Pathol Int. 65:644–651. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Lee YY, Choi CH, Sung CO, Do IG, Hub SJ, Kim HJ, Kim TJ, Lee JW, Bae DS and Kim BG: Clinical significance of changes in peripheral lymphocyte count after surgery in early cervical cancer. Gynecol Oncol. 127:107–113. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Yoon CI, Park S, Cha YJ, Lee HS, Bae SJ, Cha C, Lee DY, Ahn SG and Jeong QJ: Associations between absolute neutrophil count and lymphocyte-predominant breast cancer. Breast. 50:141–148. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Okadome K, Baba Y, Yagi T, Kiyozumi Y, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M and Baba H: Prognostic nutritional index, tumor-infiltrating lymphocytes, and prognosis in patients with esophageal cancer. Ann Surg. 271:693–700. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Okabayashi T, Nishimori I, Sugimoto T, Maeda H, Dabanaka K, Onishi S, Kobayashi M and Hanazaki K: Effects of branched-chain amino acids-enriched nutrient support for patients undergoing liver resection for hepatocellular carcinoma. J Gastroenterol Hepatol. 23:1869–1873. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Okabayashi T, Nishimori I, Nishioka A, Yamashita K, Sugimoto T, Dabanaka K, Maeda H, Kohsaki T, Ogawa Y, Kobayashi M, et al: Long-term effects of multimodal treatment for patients with resectable carcinoma of the pancreas. Oncol Rep. 20:651–656. 2008.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Saito Y, Imura S, Morine Y, Ikemoto T, Yamada S and Shimada M: Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma. Oncol Lett 21: 153, 2021.
APA
Saito, Y., Imura, S., Morine, Y., Ikemoto, T., Yamada, S., & Shimada, M. (2021). Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma. Oncology Letters, 21, 153. https://doi.org/10.3892/ol.2020.12414
MLA
Saito, Y., Imura, S., Morine, Y., Ikemoto, T., Yamada, S., Shimada, M."Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma". Oncology Letters 21.2 (2021): 153.
Chicago
Saito, Y., Imura, S., Morine, Y., Ikemoto, T., Yamada, S., Shimada, M."Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma". Oncology Letters 21, no. 2 (2021): 153. https://doi.org/10.3892/ol.2020.12414
Copy and paste a formatted citation
x
Spandidos Publications style
Saito Y, Imura S, Morine Y, Ikemoto T, Yamada S and Shimada M: Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma. Oncol Lett 21: 153, 2021.
APA
Saito, Y., Imura, S., Morine, Y., Ikemoto, T., Yamada, S., & Shimada, M. (2021). Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma. Oncology Letters, 21, 153. https://doi.org/10.3892/ol.2020.12414
MLA
Saito, Y., Imura, S., Morine, Y., Ikemoto, T., Yamada, S., Shimada, M."Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma". Oncology Letters 21.2 (2021): 153.
Chicago
Saito, Y., Imura, S., Morine, Y., Ikemoto, T., Yamada, S., Shimada, M."Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma". Oncology Letters 21, no. 2 (2021): 153. https://doi.org/10.3892/ol.2020.12414
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team