Open Access

B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma

  • Authors:
    • Kaiwen Kong
    • Yuanyu Zhao
    • Leilei Xia
    • Hui Jiang
    • Mingjuan Xu
    • Jianming Zheng
  • View Affiliations

  • Published online on: December 31, 2020     https://doi.org/10.3892/ol.2020.12420
  • Article Number: 159
  • Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer, one of the most malignant gastrointestinal tumors, is prone to liver metastasis. However, due to the lack of appropriate and comprehensive diagnostic methods, it is difficult to accurately predict the survival outcomes. Therefore, there is a need to identify effective biomarkers, such as UDP‑GlcNAc: βGal β‑1,3‑N‑acetylglucosaminyltransferase 3 (B3GNT3), that predict the survival outcome of patients with pancreatic cancer. In the present study, based on data from 171 cases of pancreatic cancer obtained from The Cancer Genome Atlas portal, the differential expression of mRNAs was screened by comparing cancerous tissues with adjacent tissues. Univariate Cox regression analysis demonstrated that B3GNT3 had prognostic capability and could be an independent prognostic factor for pancreatic adenocarcinoma (PAAD). Using the Tumor Immune Estimation Resource tool and Tumor‑Immune System Interaction Database, a potential relationship between B3GNT3 expression and immune cell infiltration was identified in pancreatic carcinoma. Furthermore, 177 samples of pancreatic carcinoma were collected and the association of CD68 expression with B3GNT3 was assessed by immunohistochemical staining. B3GNT3 expression was associated with clinical outcomes in pancreatic carcinoma and related to infiltrating levels of immune cells, which indicated that B3GNT3 could be used as an immunotherapy target for PAAD.
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February-2021
Volume 21 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Kong K, Zhao Y, Xia L, Jiang H, Xu M and Zheng J: B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma. Oncol Lett 21: 159, 2021
APA
Kong, K., Zhao, Y., Xia, L., Jiang, H., Xu, M., & Zheng, J. (2021). B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma. Oncology Letters, 21, 159. https://doi.org/10.3892/ol.2020.12420
MLA
Kong, K., Zhao, Y., Xia, L., Jiang, H., Xu, M., Zheng, J."B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma". Oncology Letters 21.2 (2021): 159.
Chicago
Kong, K., Zhao, Y., Xia, L., Jiang, H., Xu, M., Zheng, J."B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma". Oncology Letters 21, no. 2 (2021): 159. https://doi.org/10.3892/ol.2020.12420