Open Access

Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells

  • Authors:
    • Tomonori Hasegawa
    • Koh-Ichi Nakashiro
    • Chonji Fukumoto
    • Toshiki Hyodo
    • Yuta Sawatani
    • Michiko Shimura
    • Ryouta Kamimura
    • Nobuyuki Kuribayashi
    • Atsushi Fujita
    • Daisuke Uchida
    • Hitoshi Kawamata
  • View Affiliations

  • Published online on: January 4, 2021     https://doi.org/10.3892/ol.2021.12431
  • Article Number: 170
  • Copyright: © Hasegawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Molecules that demonstrate a clear association with the aggressiveness of oral squamous cell carcinoma (OSCC) have not yet been identified. The current study hypothesized that tumor cells in OSCC have three different origins: Epithelial stem cells, oral tissue stem cells from the salivary gland and bone marrow (BM) stem cells. It was also hypothesized that carcinomas derived from less‑differentiated stem cells have a greater malignancy. In the present study, sex chromosome analysis by fluorescence in situ hybridization and/or microdissection PCR was performed in patients with OSCC that developed after hematopoietic stem cell transplantation (HSCT) from the opposite sex. OSCC from 3 male patients among the 6 total transplanted patients were considered to originate from donor‑derived BM cells. A total of 2/3 patients had distant metastasis, resulting in a poor prognosis. In a female patient with oral potentially malignant disorder who underwent HSCT, there were 10.7% Y‑containing cells in epithelial cells, suggesting that some epithelial cells were from the donor. Subsequently, gene expression patterns in patients with possible BM stem cell‑derived OSCC were compared with those in patients with normally developed OSCC by microarray analysis. A total of 3 patients with BM stem cell‑derived OSCC exhibited a specific pattern of gene expression. Following cluster analysis by the probes identified on BM stem cell‑derived OSCC, 2 patients with normally developed OSCC were included in the cluster of BM stem cell‑derived OSCC. If the genes that could discriminate the origin of OSCC were identified, OSCCs were classified into the three aforementioned categories. If diagnosis can be performed based on the origin of the cancer cells, a more specific therapeutic strategy may be implemented to improve prognosis. This would be a paradigm shift in diagnostic and therapeutic strategies for OSCC.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hasegawa T, Nakashiro K, Fukumoto C, Hyodo T, Sawatani Y, Shimura M, Kamimura R, Kuribayashi N, Fujita A, Uchida D, Uchida D, et al: Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells. Oncol Lett 21: 170, 2021
APA
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M. ... Kawamata, H. (2021). Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells. Oncology Letters, 21, 170. https://doi.org/10.3892/ol.2021.12431
MLA
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M., Kamimura, R., Kuribayashi, N., Fujita, A., Uchida, D., Kawamata, H."Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells". Oncology Letters 21.2 (2021): 170.
Chicago
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M., Kamimura, R., Kuribayashi, N., Fujita, A., Uchida, D., Kawamata, H."Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells". Oncology Letters 21, no. 2 (2021): 170. https://doi.org/10.3892/ol.2021.12431