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Article Open Access

Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells

  • Authors:
    • Tomonori Hasegawa
    • Koh-Ichi Nakashiro
    • Chonji Fukumoto
    • Toshiki Hyodo
    • Yuta Sawatani
    • Michiko Shimura
    • Ryouta Kamimura
    • Nobuyuki Kuribayashi
    • Atsushi Fujita
    • Daisuke Uchida
    • Hitoshi Kawamata
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine, Tochigi 321‑0293, Japan, Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791‑0295, Japan
    Copyright: © Hasegawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 170
    |
    Published online on: January 4, 2021
       https://doi.org/10.3892/ol.2021.12431
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Abstract

Molecules that demonstrate a clear association with the aggressiveness of oral squamous cell carcinoma (OSCC) have not yet been identified. The current study hypothesized that tumor cells in OSCC have three different origins: Epithelial stem cells, oral tissue stem cells from the salivary gland and bone marrow (BM) stem cells. It was also hypothesized that carcinomas derived from less‑differentiated stem cells have a greater malignancy. In the present study, sex chromosome analysis by fluorescence in situ hybridization and/or microdissection PCR was performed in patients with OSCC that developed after hematopoietic stem cell transplantation (HSCT) from the opposite sex. OSCC from 3 male patients among the 6 total transplanted patients were considered to originate from donor‑derived BM cells. A total of 2/3 patients had distant metastasis, resulting in a poor prognosis. In a female patient with oral potentially malignant disorder who underwent HSCT, there were 10.7% Y‑containing cells in epithelial cells, suggesting that some epithelial cells were from the donor. Subsequently, gene expression patterns in patients with possible BM stem cell‑derived OSCC were compared with those in patients with normally developed OSCC by microarray analysis. A total of 3 patients with BM stem cell‑derived OSCC exhibited a specific pattern of gene expression. Following cluster analysis by the probes identified on BM stem cell‑derived OSCC, 2 patients with normally developed OSCC were included in the cluster of BM stem cell‑derived OSCC. If the genes that could discriminate the origin of OSCC were identified, OSCCs were classified into the three aforementioned categories. If diagnosis can be performed based on the origin of the cancer cells, a more specific therapeutic strategy may be implemented to improve prognosis. This would be a paradigm shift in diagnostic and therapeutic strategies for OSCC.
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1 

Johnson N, Franceschi S, Ferlay J, Ramadas K, Schmid S, MacDonald DG, Bouquot JE and Slootweg PJ: Squamous cell carcinoma. Pathology and Genetics of Head and Neck Tumours. Barnes L, Eveson JW, Reichart P and Sidransky D: World Health Organization classification of tumours. 1st edition. IARC Press; Lyon: pp. 168–175. 2005

2 

Shah JP, Zelefsky MJ and O'Malley BB: Squamous cell carcinoma of the oral cavity. Head and Neck Cancer. Harrison LB, Sessions RB and Hong WK: Lippincott-Raven; New York, USA: pp. 411–418. 1999

3 

Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, Ondrey FG, Adams GL and Gaffney PM: Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 64:55–63. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Uchida D, Begum NM, Almofti A, Nakashiro Ki, Kawamata H, Tateishi Y, Hamakawa H, Yoshida H and Sato M: Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma. Exp Cell Res. 290:289–302. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Langer CJ: Exploring biomarkers in head and neck cancer. Cancer. 118:3882–3892. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sheikh Ali MA, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, Beder LB, Demircan K, Fujii M, Yamanaka N, et al: Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma. Cancer Sci. 99:1589–1594. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, Fu KK and Milas L: Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res. 62:7350–7356. 2002.PubMed/NCBI

8 

Sheu JJ, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HS, Jinawath N, Tsai MH, Chang NW, Lin CF, et al: Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res. 69:2568–2576. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Azuma M, Yoshida H, Kawamata H, Yanagawa T, Furumoto N and Sato M: Cellular proliferation and ras oncogene of p21 21,000 expression in relation to the intracellular cyclic adenosine 3′: 5′-Monophosphate levels of a human salivary gland adenocarcinoma cell line in culture. Cancer Res. 48:2898–2903. 1988.PubMed/NCBI

10 

Shinagawa Y, Kawamata H, Omotehara F, Nakashiro Ki, Hoque MO, Furihata T, Horiuchi H, Imai Y, Fujimori T and Fujibayashi T: Evaluation of the chemosensitivity of head and neck cancer cells based on the diverse function of mutated-p53. Int J Oncol. 22:383–389. 2003.PubMed/NCBI

11 

Tachibana M, Shinagawa Y, Kawamata H, Omotehara F, Horiuchi H, Ohkura Y, Kubota K, Imai Y, Fujibayashi T and Fujimori T: RT-PCR amplification of RNA extracted from formalin-fixed, paraffin-embedded oral cancer sections: Analysis of p53 pathway. Anticancer Res. 23:2891–2896. 2003.PubMed/NCBI

12 

Hoque MO, Kawamata H, Nakashiro KI, Omotehara F, Hino S, Uchida D, Harada K, Begum NM, Yoshida H, Sato M and Fujimori T: Dysfunction of the p53 tumor suppressor pathway in head and neck cancer. Int J Oncol. 21:119–126. 2002.PubMed/NCBI

13 

Nagata M, Noman AA, Suzuki K, Kurita H, Ohnishi M, Ohyama T, Kitamura N, Kobayashi T, Uematsu K, Takahashi K, et al: ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma. BMC Cancer. 13:4102013. View Article : Google Scholar : PubMed/NCBI

14 

Kashyap T, Germain E, Roche M, Lyle S and Rabinovitz I: Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: Regulation of hemidesmosome stability modulates cell migration. Lab Invest. 91:1414–1426. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kurokawa A, Nagata M, Kitamura N, Noman AA, Ohnishi M, Ohyama T, Kobayashi T, Shingaki S and Takagi R; Oral, Maxillofacial Pathology, and Surgery Group, : Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma. Cancer. 112:1272–1281. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JM, Pan Q, Carey TE, Bradford CR, Prince ME, Cordell KG, et al: Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma. Cancer Res. 68:3959–3969. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Kawamata H, Uchida D, Hamano H, Kimura-Yanagawa T, Nakashiro KI, Hino S, Omotehara F, Yoshida H and Sato M: Active-MMP2 in cancer cell nests of oral cancer patients: Correlation with lymph node metastasis. Int J Oncol. 13:699–704. 1998.PubMed/NCBI

18 

Kawamata H, Nakashiro K, Uchida D, Harada K, Yoshida H and Sato M: Possible contribution of active MMP2 to lymphnode metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines. Int J Cancer. 70:120–127. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Mineta H, Miura K, Suzuki I, Takebayashi S, Amano H, Araki K, Harada H, Ichimura K, Wennerberg JP and Dictor MR: Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma. Cancer. 85:1011–1017. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Kanazawa T, Iwashita T, Kommareddi P, Nair T, Misawa K, Misawa Y, Ueda Y, Tono T and Carey TE: Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: Activation of the extracellular signal regulated kinase pathway and induction of cyclindependent kinase inhibitors. Oncogene. 26:5762–5771. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Supriatn o, Harada K, Yoshida H and Sato M: Basic investigation on the development of molecular targeting therapy against cyclin-dependent kinase inhibitor p27Kip1 in head and neck cancer cells. Int J Oncol. 27:627–635. 2005.PubMed/NCBI

22 

Yamamoto E, Kohama G, Sunakawa H, Iwai M and Hiratsuka H: Mode of invasion, bleomycin sensitivity and clinical course in squamous cell carcinoma of the oral cavity. Cancer. 51:2175–2180. 1983. View Article : Google Scholar : PubMed/NCBI

23 

Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J and Wright NA: Hepatocytes from non-hepatic adult stem cells. Nature. 406:2572000. View Article : Google Scholar : PubMed/NCBI

24 

Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK and Goodell MA: Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 107:1395–1402. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J and Watanabe M: Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med. 8:1011–1017. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR and Wang TC: Gastric cancer originating from bone marrow-derived cells. Science. 306:1568–1571. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, et al: PDGFRalpha-Positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia. Proc Natl Acad Sci USA. 108:6609–6614. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Kuroda Y, Kitada M, Wakao S, Nishikawa K, Tanimura Y, Makinoshima H, Goda M, Akashi H, Inutsuka A, Niwa A, et al: Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci USA. 107:8639–8643. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Kinouchi M, Izumi S, Nakashiro K, Haruyama Y, Kobashi G, Uchida D, Hasegawa T and Kawamata H: Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland? Int J Cancer. 143:2551–2560. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Arai Y, Arai H, Aoyagi A, Yamagata T, Mitani K, Kubota K, Kawamata H and Imai Y: A solid tumor of donor cell-origin after allogeneic peripheral blood stem cell transplantation. Am J Transplant. 6:3042–3043. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Pindborg JJ, Reichart PA, Smith CJ and van der Waal I: Histological Typing of Cancer and Precancer of the Oral Mucosa, 2nd edition. Springer; Berlin: 1997, PubMed/NCBI

32 

Anneroth G, Batsakis J and Luna M: Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res. 95:229–249. 1987.PubMed/NCBI

33 

Kano Y, Ishii H, Konno M, Yamasaki M, Miyata H, Nishikawa S, Hamabe A, Ogawa H, Takahashi H, Ohta K, et al: Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation. Int J Oncol. 44:443–450. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hasegawa T, Nakashiro K, Fukumoto C, Hyodo T, Sawatani Y, Shimura M, Kamimura R, Kuribayashi N, Fujita A, Uchida D, Uchida D, et al: Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells. Oncol Lett 21: 170, 2021.
APA
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M. ... Kawamata, H. (2021). Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells. Oncology Letters, 21, 170. https://doi.org/10.3892/ol.2021.12431
MLA
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M., Kamimura, R., Kuribayashi, N., Fujita, A., Uchida, D., Kawamata, H."Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells". Oncology Letters 21.2 (2021): 170.
Chicago
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M., Kamimura, R., Kuribayashi, N., Fujita, A., Uchida, D., Kawamata, H."Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells". Oncology Letters 21, no. 2 (2021): 170. https://doi.org/10.3892/ol.2021.12431
Copy and paste a formatted citation
x
Spandidos Publications style
Hasegawa T, Nakashiro K, Fukumoto C, Hyodo T, Sawatani Y, Shimura M, Kamimura R, Kuribayashi N, Fujita A, Uchida D, Uchida D, et al: Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells. Oncol Lett 21: 170, 2021.
APA
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M. ... Kawamata, H. (2021). Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells. Oncology Letters, 21, 170. https://doi.org/10.3892/ol.2021.12431
MLA
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M., Kamimura, R., Kuribayashi, N., Fujita, A., Uchida, D., Kawamata, H."Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells". Oncology Letters 21.2 (2021): 170.
Chicago
Hasegawa, T., Nakashiro, K., Fukumoto, C., Hyodo, T., Sawatani, Y., Shimura, M., Kamimura, R., Kuribayashi, N., Fujita, A., Uchida, D., Kawamata, H."Oral squamous cell carcinoma may originate from bone marrow‑derived stem cells". Oncology Letters 21, no. 2 (2021): 170. https://doi.org/10.3892/ol.2021.12431
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