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Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma

  • Authors:
    • Hongcheng Jia
    • Xuan Wang
    • Zheng Sun
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, Department of Stomatology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China, Department of Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 172
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    Published online on: January 4, 2021
       https://doi.org/10.3892/ol.2021.12433
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Abstract

Oral squamous cell carcinoma (OSCC), characterized by a high recurrence rate, a poor prognosis and high morbidity, is the most prevalent malignancy of the oral cavity. The aberrant expression of long non‑coding RNAs (lncRNAs) may lead to the development of various diseases, including cancer. Delayed diagnosis is the main reason for the poor prognosis. Therefore, the present study aimed to investigate the differential expression profiles of plasma lncRNAs in OSCC in order to screen target lncRNAs as biomarkers for the early diagnosis and staging of OSCC. The expression profiles of lncRNAs and mRNAs in OSCC were analyzed by microarray analysis. A total of 14 candidate lncRNAs were selected and analyzed using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) using the array homologous samples. Subsequently, 4 target lncRNAs were measured by RT‑qPCR in a large cohort, including 28 cases with TNM I/II [early‑stage squamous cell carcinoma (ESCC) group], 36 cases with TNM III/IV [advanced‑stage squamous cell carcinoma (ASCC) group], 16 cases with dysplasia [oral premalignant lesion (OPL) group] and 16 healthy controls (H group). Receiver operating characteristic (ROC) curves and logistic regression analysis were used to evaluate the diagnostic effects of the combined lncRNAs. In total, 6,606 differentially expressed lncRNAs and 4,196 mRNAs were identified in OSCC. The expression trend of the 14 candidate lncRNAs was consistent with the microarray data. The expression level of ENST00000412740, NR_131012, ENST00000588803 and NR_038323 exhibited significant differences in the H, OPL, ESCC and ASCC groups (P<0.05). ROC curve and logistic regression analyses revealed that the diagnostic efficacy of the combined lncRNAs was more prominent than that of a single lncRNA, particularly in the ESCC and ASCC groups. In conclusion, the present study identified the differential expression profiles of plasma lncRNAs in OSCC and demonstrated that ENST00000412740, NR_131012, ENST00000588803 and NR_038323 may be promising biomarkers for the early diagnosis and staging of OSCC. These findings may provide novel targets for the early diagnosis and staging of OSCC, which may provide an objective basis for clinical decision‑making.
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1 

Gupta B, Johnson NW and Kumar N: Global epidemiology of head and neck cancers: A continuing challenge. Oncology. 91:13–23. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Sinevici N and O'sullivan J: Oral cancer: Deregulated molecular events and their use as biomarkers. Oral Oncol. 61:12–18. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Ghani WMN, Ramanathan A, Prime SS, Yang YH, Razak IA, Abdul Rahman ZA, Abraham MT, Mustafa WMW, Tay KK, Kallarakkal TG, et al: Survival of oral cancer patients in different ethnicities. Cancer Invest. 37:275–287. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Alonso JE, Han AY, Kuan EC, Strohl M, Clai JM, St John MA, Ryan WR and Heaton CM: The survival impact of surgical therapy in squamous cell carcinoma of the hard palate. Laryngoscope. 128:2050–2055. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Bloebaum M, Poort L, Bockmann R and Kessler P: Survival after curative surgical treatment for primary oral squamous cell carcinoma. J Craniomaxillofac Surg. 42:1572–1576. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kornienk AE, Guenzl PM, Barlow DP and Pauler FM: Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 11:592013. View Article : Google Scholar : PubMed/NCBI

9 

Geisler S and Coller J: RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 14:699–712. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends Cell Biol. 21:354–361. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Lalevee S and Fei R: Long noncoding RNAs in human disease: Emerging mechanisms and therapeutic strategies. Epigenomics. 7:877–879. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Chandra Gupta S and Nandan Tripathi Y: Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets. Int J Cancer. 140:1955–1967. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zhang L, Meng X, Zhu XW, Yang DC, Chen R, Jiang Y and Xu T: Long non-coding RNAs in Oral squamous cell carcinoma: Biologic function, mechanisms and clinical implications. Mol Cancer. 18:1022019. View Article : Google Scholar : PubMed/NCBI

14 

Ren S, Wang F, Shen J, Sun Y, Xu W, Lu J, Wei M, Xu C, Wu C, Zhang Z, et al: Long non-coding RNA metastasis associated in 1ung adenocarcinoma transcript l derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer. Eur J Cancer. 49:2949–2959. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Sun M, Jin FY, Xia R, Kong R, Li JH, Xu TP, Liu YW, Zhang EB, Liu XH and De W: Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. BMC Cancer. 14:3192014. View Article : Google Scholar : PubMed/NCBI

17 

Gibb EA, Enfield KS, Stewart GL, Lonergan KM, Chari R, Ng RT, Zhang L, MacAulay CE, Rosin MP and Lam WL: Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncol. 47:1055–1061. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Tang H, Wu Z, Zhang J and Su B: Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Rep. 7:761–766. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Fang Z, Wu L, Wang L, Yang Y, Meng Y and Yang HL: Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: A possible correlation with cancer metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol. 117:89–95. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Jia H, Wang X and Sun Z: Exploring the long noncoding RNAs-based biomarkers and pathogenesis of malignant transformation from dysplasia to oral squamous cell carcinoma by bioinformatics method. Eur J Cancer Prev. 29:174–181. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Jia H, Wang X and Sun Z: Exploring the molecular pathogenesis and biomarkers of high risk oral premalignant lesions on the basis of long noncoding RNA expression profiling by serial analysis of gene expression. Eur J Cancer Prev. 27:370–378. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Shao T, Huang J, Zheng Z, Wu Q, Liu T and Lv X: SCCA, TSGF, and the long non-coding RNA AC007271.3 are effective biomarkers for diagnosing oral squamous cell carcinoma. Cell Physiol Biochem. 47:26–38. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Sciubba JJ: Oral cancer: The importance of early diagnosis and treatment. Am J Clin Dermalol. 2:239–251. 2001. View Article : Google Scholar

25 

Meseure D, Drak Alsibai K, Nicolas A, Bieche I and Morillon A: Long noncoding RNAs as architects in cancer epigenetics, prognostic biomarkers, and potential therapeutic targets. Biomed Res Int. 2015:3202142015. View Article : Google Scholar : PubMed/NCBI

26 

Kladi-Skandali A, Michaelidou K, Scorilas A and Mavridis K: Long noncoding rnas in digestive system malignancies: A novel class of cancer biomarkers and therapeutic targets? Gastroenterol Res Pract. 2015:3198612015. View Article : Google Scholar : PubMed/NCBI

27 

Fatima R, Akhade VS, Pal D and Rao SM: Long noncoding RNAs in development and cancer: Potential biomarkers and therapeutic targets. Mol Cell Ther. 3:52015. View Article : Google Scholar : PubMed/NCBI

28 

Tang Q, Ni Z, Cheng Z, Xu J, Yu H and Yin P: Three circulating long non-coding RNAs act as biomarkers for predicting NSCLC. Cell Physiol Biochem. 37:1002–1009. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Li J, Wang X, Tang J, Jiang R, Zhang W, Ji J and Sun B: HULC and Linc00152 act as novel biomarkers in predicting diagnosis of hepatocellular carcinoma. Cell Physiol Biochem. 37:687–696. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Ge Q, Zhou Y, Lu J, Bai Y, Xie X and Lu Z: miRNA in plasma exosome is stable under different storage conditions. Molecules. 19:1568–1575. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Tsui NB, Ng EK and Lo YM: Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin Chem. 48:1647–1653. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Schlosser K, Hanson K, Villeneuve PK, Dimitroulakos J, McIntyre L, Pilote L and Stewart DJ: Assessment of circulating LncRNAs under physiologic and pathologic conditions in humans reveals potential limitations as biomarkers. Sci Rep. 6:365962016. View Article : Google Scholar : PubMed/NCBI

33 

Mercer TR, Gerhardt DJ, Dinger ME, Crawford J, Trapnell C, Jeddeloh JA, Mattick JS and Rinn JL: Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Nat Biotechnol. 30:99–104. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Prensner JR, Iyer MK, Sahu A, Asangani IA, Cao Q, Patel L, Vergara IA, Davicioni E, Erho N, Ghadessi M, et al: The long noncoding RNA SChLAPI promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet. 45:1392–1298. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Kurokawa H, Yamashita Y, Tokudome S and Kajiyama M: Combination assay for tumor markers in oral squamous cell carcinoma. J Oral Maxillofac Surg. 55:964–966. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Clemson CM, Hutchinson JN, Sara SA, Ensminger AW, Fox AH, Chess A and Lawrence JB: An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol cell. 33:717–726. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Leemans CR, Braakhuis BJ and Brakenhoff RH: The molecular biology of head and neck cancer. Nat Rev Cancer. 11:9–22. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Smeets SJ, van der Plas M, Schaaij-Visser TB, van Veen EA, van Meerloo J, Braakhuis BJ, Steenbergen RD and Brakenhoff RH: Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways. Int J Cancer. 128:1596–1605. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Graveland AP, Bremmer JF, de Maaker M, Brink A, Cobussen P, Zwart M, Braakhuis BJ, Bloemena E, van der Waal I, Leemans CR and Brakenhoff RH: Molecular screening of oral precancer. Oral Oncol. 49:1129–1135. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijinhoven PW, Radaelli E, Vermi W, et al: p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med. 22:861–868. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Fang J, Qiao F, Tu J, Xu J, Ding F, Liu Y, Akuo BA, Hu J and Shao S: High expression of long non-coding RNA NEAT1 indicates poor prognosis of human cancer. Oncotarget. 8:45918–45927. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jia H, Wang X and Sun Z: Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma. Oncol Lett 21: 172, 2021.
APA
Jia, H., Wang, X., & Sun, Z. (2021). Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma. Oncology Letters, 21, 172. https://doi.org/10.3892/ol.2021.12433
MLA
Jia, H., Wang, X., Sun, Z."Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma". Oncology Letters 21.2 (2021): 172.
Chicago
Jia, H., Wang, X., Sun, Z."Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma". Oncology Letters 21, no. 2 (2021): 172. https://doi.org/10.3892/ol.2021.12433
Copy and paste a formatted citation
x
Spandidos Publications style
Jia H, Wang X and Sun Z: Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma. Oncol Lett 21: 172, 2021.
APA
Jia, H., Wang, X., & Sun, Z. (2021). Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma. Oncology Letters, 21, 172. https://doi.org/10.3892/ol.2021.12433
MLA
Jia, H., Wang, X., Sun, Z."Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma". Oncology Letters 21.2 (2021): 172.
Chicago
Jia, H., Wang, X., Sun, Z."Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma". Oncology Letters 21, no. 2 (2021): 172. https://doi.org/10.3892/ol.2021.12433
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