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Case Report Open Access

Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports

  • Authors:
    • Shandong Tao
    • Lixiao Song
    • Yuan Deng
    • Yue Chen
    • Yimin Gan
    • Yunjie Li
    • Yihan Ding
    • Zhe Zhang
    • Banghe Ding
    • Zhengmei He
    • Chunling Wang
    • Liang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
    Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 178
    |
    Published online on: January 6, 2021
       https://doi.org/10.3892/ol.2021.12439
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Abstract

The prognosis of patients with relapsed/refractory acute myeloid leukemia (R/R AML) is poor, with a 3‑year overall survival rate of 10%. Patients with translocation (t)(11;19)(q23;p13) have a higher risk of relapse and there is no optimal regimen for these patients. The present study treated two young patients with t(11;19)(q23;p13) AML, who relapsed after one or two cycles of consolidation, with a salvage treatment consisting of sequential cladribine, cytarabine and etoposide (CLAE) and allogeneic hematopoietic stem cell transplantation (allo‑HSCT). Both neutrophil and platelet engraftments were achieved within 15 days, and no severe transplant‑related complications and graft‑versus‑host diseases were observed. Following allo‑HSCT, both patients achieved complete hematologic and cytogenetic remission. Decitabine was used for the prophylaxis of relapse. The two patients remained alive and disease‑free for 100 days following allo‑HSCT. The results presented here suggest that CLAE regimen sequential with allo‑HSCT may be effective in treating patients with R/R AML, with t(11;19)(q23;p13). However, further studies and a larger sample size are required to validate the effectiveness of this treatment regimen.
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Copy and paste a formatted citation
Spandidos Publications style
Tao S, Song L, Deng Y, Chen Y, Gan Y, Li Y, Ding Y, Zhang Z, Ding B, He Z, He Z, et al: Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports. Oncol Lett 21: 178, 2021.
APA
Tao, S., Song, L., Deng, Y., Chen, Y., Gan, Y., Li, Y. ... Yu, L. (2021). Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports. Oncology Letters, 21, 178. https://doi.org/10.3892/ol.2021.12439
MLA
Tao, S., Song, L., Deng, Y., Chen, Y., Gan, Y., Li, Y., Ding, Y., Zhang, Z., Ding, B., He, Z., Wang, C., Yu, L."Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports". Oncology Letters 21.3 (2021): 178.
Chicago
Tao, S., Song, L., Deng, Y., Chen, Y., Gan, Y., Li, Y., Ding, Y., Zhang, Z., Ding, B., He, Z., Wang, C., Yu, L."Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports". Oncology Letters 21, no. 3 (2021): 178. https://doi.org/10.3892/ol.2021.12439
Copy and paste a formatted citation
x
Spandidos Publications style
Tao S, Song L, Deng Y, Chen Y, Gan Y, Li Y, Ding Y, Zhang Z, Ding B, He Z, He Z, et al: Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports. Oncol Lett 21: 178, 2021.
APA
Tao, S., Song, L., Deng, Y., Chen, Y., Gan, Y., Li, Y. ... Yu, L. (2021). Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports. Oncology Letters, 21, 178. https://doi.org/10.3892/ol.2021.12439
MLA
Tao, S., Song, L., Deng, Y., Chen, Y., Gan, Y., Li, Y., Ding, Y., Zhang, Z., Ding, B., He, Z., Wang, C., Yu, L."Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports". Oncology Letters 21.3 (2021): 178.
Chicago
Tao, S., Song, L., Deng, Y., Chen, Y., Gan, Y., Li, Y., Ding, Y., Zhang, Z., Ding, B., He, Z., Wang, C., Yu, L."Successful treatment of two relapsed patients with t(11;19)(q23;p13) acute myeloid leukemia by CLAE chemotherapy sequential with allogeneic hematopoietic stem cell transplantation: Case reports". Oncology Letters 21, no. 3 (2021): 178. https://doi.org/10.3892/ol.2021.12439
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