Open Access

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

  • Authors:
    • Xing Zhao
    • Dayong Sun
    • Gang Zhang
  • View Affiliations

  • Published online on: January 6, 2021     https://doi.org/10.3892/ol.2021.12443
  • Article Number: 182
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor, which mainly originates from FDCs in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes due to the existence of acquired lymphoid tissue, which becomes the histological basis of the tumor. The diagnosis of FDCS, particularly extranodal FDCS, presents a challenge for pathologists and hematopathologists. The present study presents two cases of extranodal FDCS based on clinical features and histomorphology. Soft tissue of the chest wall was involved in case 1 and right tonsil tissue in case 2. Case 1 underwent surgery, and was in good health post‑operatively. During the 5‑month post‑operative follow‑up period, the patient was healthy in all respects. Case 2 received surgery combined with radiotherapy, and the follow‑up data reported that the patient remained alive, without signs of recurrence or metastasis during the 4‑month post‑operative follow‑up period. Additionally, a total of 102 cases of extranodal FDCS were retrieved from the literature, which were extracted and reviewed carefully. The rates of recurrence, metastasis and mortality were 14.63 (12/82), 17.07 (14/82) and 8.29% (15/82), respectively. The overall survival rates of the 102 cases, showing 2‑year total survival rates, were 70%, the same with that of 5‑year total survival rates. The 2‑year tumor‑free total survival rates were 68%, and the 5‑year equivalents were 32%. Female patients had a poorer prognosis than male patients (P<0.05). Kaplan‑Meier estimation presented no statistically significant differences between disease‑free survival rates or overall survival rates and age, tumor size or treatment (P>0.05).
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March-2021
Volume 21 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao X, Sun D and Zhang G: Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases. Oncol Lett 21: 182, 2021.
APA
Zhao, X., Sun, D., & Zhang, G. (2021). Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases. Oncology Letters, 21, 182. https://doi.org/10.3892/ol.2021.12443
MLA
Zhao, X., Sun, D., Zhang, G."Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases". Oncology Letters 21.3 (2021): 182.
Chicago
Zhao, X., Sun, D., Zhang, G."Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases". Oncology Letters 21, no. 3 (2021): 182. https://doi.org/10.3892/ol.2021.12443