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Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway

  • Authors:
    • Wenqi Huang
    • Hang Sun
    • Ting Hu
    • Dongju Zhu
    • Xianli Long
    • Hui Guo
    • Qi Liu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Department of Nephrology, The Affiliated Hospital of Panzhihua University, Panzhihua, Sichuan 617000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 197
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    Published online on: January 12, 2021
       https://doi.org/10.3892/ol.2021.12458
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Abstract

Multiple myeloma (MM) is the second most common haematological malignancy and remains an incurable disease, with most patients relapsing and requiring further treatment. Augmenter of liver regeneration (ALR) is a vital protein affecting fundamental processes such as energy transduction, cell survival and regeneration. Silencing ALR inhibits cell proliferation and triggers apoptosis in human MM U266 cells. However, little is known about the role of 15‑kDa‑ALR on MM. In the present study, the role of 15‑kDa‑ALR in human MM cells was investigated. Blocking extracellular 15‑kDa‑ALR with an anti‑ALR monoclonal antibody (McAb) decreased the proliferation and viability of U266 cells. However, the results of flow cytometry revealed no changes in apoptosis, and the expression levels of Bax, Bcl‑2, caspase‑3 and cleaved caspase‑3 were not affected. However, combined treatment with anti‑ALR McAb and epirubicin increased the apoptosis of U266 cells. RNA sequencing results indicated that the ERK1/2, JNK‑MAPK and STAT3 signaling pathways, as well as the cell cycle, were associated with the mechanism of action of the anti‑ALR McAb, and PCR, western blotting and cell cycle analysis confirmed these results. The present findings suggested that blocking extracellular 15‑kDa‑ALR in U266 cells with an anti‑ALR McAb decreased cell proliferation via the MAPK, STAT3 and cell cycle signaling pathways without increasing apoptosis. Thus, 15‑kDa‑ALR may be a new therapeutic target for myeloma.
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View References

1 

Kazandjian D: Multiple myeloma epidemiology and survival: A unique malignancy. Semin Oncol. 43:676–681. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Kristinsson SY, Anderson WF and Landgren O: Improved long-term survival in multiple myeloma up to the age of 80 years. Leukemia. 28:1346–1348. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Landgren O and Iskander K: Modern multiple myeloma therapy: Deep, sustained treatment response and good clinical outcomes. J Intern Med. 281:365–382. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Sonneveld P and Broijl A: Treatment of relapsed and refractory multiple myeloma. Haematologica. 101:396–406. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hagiya M, Francavilla A, Polimeno L, Ihara I, Sakai H, Seki T, Shimonishi M, Porter KA and Starzl TE: Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: Expression of biologically active recombinant ALR and demonstration of tissue distribution. Proc Natl Acad Sci USA. 91:8142–8146. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Lu J, Xu WX, Zhan YQ, Cui XL, Cai WM, He FC and Yang XM: Identification and characterization of a novel isoform of hepatopoietin. World J Gastroenterol. 8:353–356. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Hofhaus G, Lee JE, Tews I, Rosenberg B and Lisowsky T: The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre. Eur J Biochem. 270:1528–1535. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Cheng J, Zhong YW, Liu Y, Dong J, Yang JZ and Chen JM: Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration. World J Gastroenterol. 6:275–277. 2000.PubMed/NCBI

9 

Gandhi CR, Kuddus R, Subbotin VM, Prelich J, Murase N, Rao AS, Nalesnik MA, Watkins SC, DeLeo A, Trucco M, et al: A fresh look at augmenter of liver regeneration in rats. Hepatology. 29:1435–1445. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Fass D: The Erv family of sulfhydryl oxidases. Biochim Biophys Acta. 1783:557–566. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Jung YS, Kim SJ, Kwon DY, Jun DS and Kim YC: Significance of alterations in the metabolomics of sulfur-containing amino acids during liver regeneration. Biochimie. 95:1605–1610. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Ferecatu I, Gonçalves S, Golinelli-Cohen MP, Clémancey M, Martelli A, Riquier S, Guittet E, Latour JM, Puccio H, Drapier JC, et al: The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1. J Biol Chem. 289:28070–28086. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Todd LR, Damin MN, Gomathinayagam R, Horn SR, Means AR and Sankar U: Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. Mol Biol Cell. 21:1225–1236. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Ibrahim S and Weiss TS: Augmenter of liver regeneration: Essential for growth and beyond. Cytokine Growth Factor Rev. 45:65–80. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Zeng HQ, Luo Y, Lou SF, Liu Q, Zhang L and Deng JC: Silencing of augmenter of liver regeneration inhibited cell proliferation and triggered apoptosis in U266 human multiple myeloma cells. Braz J Med Biol Res. 50:e61392017. View Article : Google Scholar : PubMed/NCBI

16 

Kim HY, Stojadinovic A and Izadjoo MJ: Immunization, hybridoma generation, and selection for monoclonal antibody production. Methods Mol Biol. 1131:33–45. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Anders S and Huber W: Differential expression analysis for sequence count data. Genome Biol. 11:R1062010. View Article : Google Scholar : PubMed/NCBI

18 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C, et al: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41D:D808–D815. 2013.

19 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Vodovotz Y, Prelich J, Lagoa C, Barclay D, Zamora R, Murase N and Gandhi CR: Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: In vitro, in vivo and in silico studies. Mol Med. 18:1421–1429. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Cao Y, Fu YL, Yu M, Yue PB, Ge CH, Xu WX, Zhan YQ, Li CY, Li W and Wang XH: Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress. Free Radic Biol Med. 47:1057–1066. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45D:D353–D361. 2017. View Article : Google Scholar

24 

Sun Y, Liu WZ, Liu T, Feng X, Yang N and Zhou HF: Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 35:600–604. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Giorda R, Hagiya M, Seki T, Shimonishi M, Sakai H, Michaelson J, Francavilla A, Starzl TE and Trucco M: Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med. 2:97–108. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Yu HY, Xiang DR, Huang HJ, Li J and Sheng JF: Expression level of augmenter of liver regeneration in patients with hepatic failure and hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 9:492–498. 2010.PubMed/NCBI

27 

Gatzidou E, Mantzourani M, Giaginis C, Giagini A, Patsouris E, Kouraklis G and Theocharis S: Augmenter of liver regeneration gene expression in human colon cancer cell lines and clinical tissue samples. J BUON. 20:84–91. 2015.PubMed/NCBI

28 

Shen Y, Liu Q, Sun H, Li X, Wang N and Guo H: Protective effect of augmenter of liver regeneration on vincristine-induced cell death in Jurkat T leukemia cells. Int Immunopharmacol. 17:162–167. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Polimeno L, Pesetti B, Lisowsky T, Iannone F, Resta L, Giorgio F, Mallamaci R, Buttiglione M, Santovito D, Vitiello F, et al: Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Free Radic Res. 43:865–875. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Polimeno L, Pesetti B, De Santis F, Resta L, Rossi R, De Palma A, Girardi B, Amoruso A and Francavilla A: Decreased expression of the augmenter of liver regeneration results in increased apoptosis and oxidative damage in human-derived glioma cells. Cell Death Dis. 3:e2892012. View Article : Google Scholar : PubMed/NCBI

31 

Zhang LM, Liu DW, Liu JB, Zhang XL, Wang XB, Tang LM and Wang LQ: Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats. World J Gastroenterol. 11:3680–3685. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Ilowski M, Kleespies A, de Toni EN, Donabauer B, Jauch KW, Hengstler JG and Thasler WE: Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis. Biochem Biophys Res Commun. 404:148–152. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Dayoub R, Thasler WE, Bosserhoff AK, Singer T, Jauch KW, Schlitt HJ and Weiss TS: Regulation of polyamine synthesis in human hepatocytes by hepatotrophic factor augmenter of liver regeneration. Biochem Biophys Res Commun. 345:181–187. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Polimeno L, Pesetti B, Annoscia E, Giorgio F, Francavilla R, Lisowsky T, Gentile A, Rossi R, Bucci A and Francavilla A: Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats. Free Radic Res. 45:534–549. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Liao XH, Zhang L, Liu Q, Sun H, Peng CM and Guo H: Augmenter of liver regeneration protects kidneys from ischaemia/reperfusion injury in rats. Nephrol Dial Transplant. 25:2921–2929. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Liao XH, Chen GT, Li Y, Zhang L, Liu Q, Sun H and Guo H: Augmenter of liver regeneration attenuates tubular cell apoptosis in acute kidney injury in rats: The possible mechanisms. Ren Fail. 34:590–599. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Wang N, Sun H, Shen Y, Li XF, Pan T, Liu GL and Liu Q: Augmenter of liver regeneration inhibits apoptosis of activated human peripheral blood lymphocytes in vitro. Immunopharmacol Immunotoxicol. 35:257–263. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Francavilla A, Vujanovic NL, Polimeno L, Azzarone A, Iacobellis A, Deleo A, Hagiya M, Whiteside TL and Starzl TE: The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions. Hepatology. 25:411–415. 1997. View Article : Google Scholar : PubMed/NCBI

39 

Weiss TS, Lupke M, Ibrahim S, Buechler C, Lorenz J, Ruemmele P, Hofmann U, Melter M and Dayoub R: Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways. Plos One. 12:e01842822017. View Article : Google Scholar : PubMed/NCBI

40 

Huang TC, Chiu PR, Chang WT, Hsieh BS, Huang YC, Cheng HL, Huang LW, Hu YC and Chang KL: Epirubicin induces apoptosis in osteoblasts through death-receptor and mitochondrial pathways. Apoptosis. 23:226–236. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Li Y, Li M, Xing G, Hu Z, Wang Q, Dong C, Wei H, Fan G, Chen J, Yang X, et al: Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin. J Biol Chem. 275:37443–37447. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Zhu J, Bing C and Wilding JPH: 1α,25(OH)2D3 attenuates IL-6 and IL-1β-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-κB signaling pathways. Diabetol Metab Syndr. 11:92019. View Article : Google Scholar : PubMed/NCBI

43 

Yu Y, Wei SG, Zhang ZH, Weiss RM and Felder RB: ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction. Am J Physiol Heart Circ Physiol. 310:H732–H739. 2016. View Article : Google Scholar : PubMed/NCBI

44 

von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, et al: Cell fate decisions are specified by the dynamic ERK interactome. Nat Cell Biol. 11:1458–1464. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Sławińska-Brych A, Zdzisińska B, Czerwonka A, Mizerska-Kowalska M, Dmoszyńska-Graniczka M, Stepulak A and Gagoś M: Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production. Biochim Biophys Acta, Gen Subj. 1863:1294082019. View Article : Google Scholar

46 

Park S, Lee HJ, Jeong SJ, Song HS, Kim M, Lee HJ, Lee EO, Kim DH, Ahn KS and Kim SH: Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. Food Chem Toxicol. 49:1367–1372. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Dayoub R, Buerger L, Ibrahim S, Melter M and Weiss TS: Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response. Exp Mol Pathol. 102:428–433. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Teng EC, Todd LR, Ribar TJ, Lento W, Dimascio L, Means AR and Sankar U: Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells. Mol Biol Cell. 22:1312–1320. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Yang J, Chen L, Yan Y, Qiu J, Chen J, Song J, Rao Q, Ben-David Y, Li Y and Hao X: BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells. Biomed Pharmacother. 112:1086032019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang W, Sun H, Hu T, Zhu D, Long X, Guo H and Liu Q: Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway. Oncol Lett 21: 197, 2021.
APA
Huang, W., Sun, H., Hu, T., Zhu, D., Long, X., Guo, H., & Liu, Q. (2021). Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway. Oncology Letters, 21, 197. https://doi.org/10.3892/ol.2021.12458
MLA
Huang, W., Sun, H., Hu, T., Zhu, D., Long, X., Guo, H., Liu, Q."Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway". Oncology Letters 21.3 (2021): 197.
Chicago
Huang, W., Sun, H., Hu, T., Zhu, D., Long, X., Guo, H., Liu, Q."Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway". Oncology Letters 21, no. 3 (2021): 197. https://doi.org/10.3892/ol.2021.12458
Copy and paste a formatted citation
x
Spandidos Publications style
Huang W, Sun H, Hu T, Zhu D, Long X, Guo H and Liu Q: Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway. Oncol Lett 21: 197, 2021.
APA
Huang, W., Sun, H., Hu, T., Zhu, D., Long, X., Guo, H., & Liu, Q. (2021). Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway. Oncology Letters, 21, 197. https://doi.org/10.3892/ol.2021.12458
MLA
Huang, W., Sun, H., Hu, T., Zhu, D., Long, X., Guo, H., Liu, Q."Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway". Oncology Letters 21.3 (2021): 197.
Chicago
Huang, W., Sun, H., Hu, T., Zhu, D., Long, X., Guo, H., Liu, Q."Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway". Oncology Letters 21, no. 3 (2021): 197. https://doi.org/10.3892/ol.2021.12458
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