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A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy

  • Authors:
    • Peiqi Zhao
    • Lei Zhu
    • Lanfang Li
    • Shiyong Zhou
    • Lihua Qiu
    • Zhengzi Qian
    • Wengui Xu
    • Huilai Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Lymphoma, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, P.R. China, Department of Molecular Imaging and Nuclear Medicine, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 218
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    Published online on: January 20, 2021
       https://doi.org/10.3892/ol.2021.12479
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Abstract

In the era of immunochemotherapy, the traditional international prognostic index (IPI) has partially lost its predictive value in diffuse large B‑cell lymphoma (DLBCL) and the National Comprehensive Cancer Network‑IPI (NCCN‑IPI) is unable to effectively identify high‑risk patients. Thus, the present study aimed to develop a modified prognostic model (M‑PM) to identify high‑risk patients that require aggressive treatment. The present study included 169 patients with newly diagnosed DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (RCHOP) or RCHOP‑like regimens, between 2011‑2017. The results demonstrated that the risk discrimination was improved in the NCCN‑IPI compared with the IPI, and patients were divided into four risk groups with a 5‑year overall survival rate of 93.8, 76.5, 54.3 and 39.4%, respectively. However, the NCCN‑IPI failed to identify the high‑risk DLBCL population. The newly developed M‑PM presented here included four parameters: Age (≥65 years), an elevated lactate dehydrogenase level, Eastern Cooperative Oncology Group score ≥2 and total metabolic tumor volume ≥300 cm3. The M‑PM also divided patients into four risk groups that comprised 40.8, 23.1, 26.0 and 10.1% of the patients, and the 5‑year survival rates of these groups were 92.4, 70.6, 52.3 and 24.5%, respectively. Taken together, the results of the present study demonstrated that the M‑PM was more accurate compared with the IPI and the NCCN‑IPI, which served as an effective tool for identifying patients with DLBCL at high risk of an adverse prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao P, Zhu L, Li L, Zhou S, Qiu L, Qian Z, Xu W and Zhang H: A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy. Oncol Lett 21: 218, 2021.
APA
Zhao, P., Zhu, L., Li, L., Zhou, S., Qiu, L., Qian, Z. ... Zhang, H. (2021). A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy. Oncology Letters, 21, 218. https://doi.org/10.3892/ol.2021.12479
MLA
Zhao, P., Zhu, L., Li, L., Zhou, S., Qiu, L., Qian, Z., Xu, W., Zhang, H."A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy". Oncology Letters 21.3 (2021): 218.
Chicago
Zhao, P., Zhu, L., Li, L., Zhou, S., Qiu, L., Qian, Z., Xu, W., Zhang, H."A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy". Oncology Letters 21, no. 3 (2021): 218. https://doi.org/10.3892/ol.2021.12479
Copy and paste a formatted citation
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Spandidos Publications style
Zhao P, Zhu L, Li L, Zhou S, Qiu L, Qian Z, Xu W and Zhang H: A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy. Oncol Lett 21: 218, 2021.
APA
Zhao, P., Zhu, L., Li, L., Zhou, S., Qiu, L., Qian, Z. ... Zhang, H. (2021). A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy. Oncology Letters, 21, 218. https://doi.org/10.3892/ol.2021.12479
MLA
Zhao, P., Zhu, L., Li, L., Zhou, S., Qiu, L., Qian, Z., Xu, W., Zhang, H."A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy". Oncology Letters 21.3 (2021): 218.
Chicago
Zhao, P., Zhu, L., Li, L., Zhou, S., Qiu, L., Qian, Z., Xu, W., Zhang, H."A modified prognostic model in patients with diffuse large B‑cell lymphoma treated with immunochemotherapy". Oncology Letters 21, no. 3 (2021): 218. https://doi.org/10.3892/ol.2021.12479
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