Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer

  • Authors:
    • Chul Min Yang
    • Moo-Koo Kang
    • Woong-Jae Jung
    • Jung-Sik Joo
    • Yong-Jin Kim
    • Yeeun Choi
    • Hyoung-Pyo Kim
  • View Affiliations / Copyright

    Affiliations: Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 120‑752, Republic of Korea, Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120‑752, Republic of Korea
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 226
    |
    Published online on: January 24, 2021
       https://doi.org/10.3892/ol.2021.12487
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

One of the most commonly used drugs in chemotherapy, 5‑fluorouracil (5‑FU) has been shown to be effective in only 10‑15% of patients with colon cancer. Thus, studies of the mechanisms affecting 5‑FU sensitivity in these patients are necessary. The tumor suppressor protein p53 is a transcription factor that serves important roles in cell apoptosis by regulating the cell cycle. It has also been characterized as a key factor influencing drug sensitivity. Furthermore, accessible chromatin is a hallmark of active DNA regulatory elements and functions as a crucial epigenetic factor regulating cancer mechanisms. The present study assessed the genetic regulatory landscape in colon cancer by performing RNA sequencing and Assay for Transposase‑Accessible Chromatin sequencing, and investigated the effects of 5‑FU on chromatin accessibility and gene expression. Notably, while treatment with 5‑FU mediated global increases in chromatin accessibility, chromatin organization in several genomic regions differed depending on the expression status of p53. Since the occupancy of p53 does not overlap with accessible chromatin regions, the 5‑FU‑mediated changes in chromatin accessibility were not regulated by direct binding of p53. In the p53‑expressing condition, the 5‑FU‑mediated accessible chromatin region was primarily associated with genes encoding cell death pathways. Additionally, 5‑FU was revealed to induce open chromatin conformation at regions containing binding motifs for AP‑1 family transcription factors, which may drive expression of apoptosis pathway genes. In conclusion, expression of p53 may confer 5‑FU sensitivity by regulating chromatin accessibility of distinct genes associated with cell apoptosis in a transcription‑independent manner.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Diasio RB and Harris BE: Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet. 16:215–237. 1989. View Article : Google Scholar : PubMed/NCBI

2 

Jordan VC: A Retrospective: On clinical studies with 5-fluorouracil. Cancer Res. 76:767–768. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Zhang N, Yin Y, Xu SJ and Chen WS: 5-Fluorouracil: Mechanisms of resistance and reversal strategies. Molecules. 13:1551–1569. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Russo A, Bazan V, Iacopetta B, Kerr D, Soussi T and Gebbia N; TP53-CRC Collaborative Study Group, : The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol. 23:7518–7528. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Giovannetti E, Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Poupon MF, Azzarello A, Pinedo HM and Peters GJ: Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br J Cancer. 96:769–775. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Dominijanni A and Gmeiner WH: Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations. Cancer Drug Resist. 1:48–58. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Moll UM, Marchenko N and Zhang XK: p53 and Nur77/TR3-transcription factors that directly target mitochondria for cell death induction. Oncogene. 25:4725–4743. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Leu JI, Dumont P, Hafey M, Murphy ME and George DL: Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 6:443–450. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P and Moll UM: p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 11:577–590. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Dall'Agnese A, Caputo L, Nicoletti C, di Iulio J, Schmitt A, Gatto S, Diao Y, Ye Z, Forcato M, Perera R, et al: Transcription factor-directed re-wiring of chromatin architecture for somatic cell nuclear reprogramming toward trans-differentiation. Mol Cell. 76:453–472.e8. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Paliou C, Guckelberger P, Schöpflin R, Heinrich V, Esposito A, Chiariello AM, Bianco S, Annunziatella C, Helmuth J, Haas S, et al: Preformed chromatin topology assists transcriptional robustness of Shh during limb development. Proc Natl Acad Sci USA. 116:12390–12399. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Sobczak M, Pitt AR, Spickett CM and Robaszkiewicz A: PARP1 Co-regulates EP300-BRG1-dependent transcription of genes involved in breast cancer cell proliferation and DNA repair. Cancers (Basel). 11:15392019. View Article : Google Scholar

13 

Zhou ZH, Wang QL, Mao LH, Li XQ, Liu P, Song JW, Liu X, Xu F, Lei J and He S: Chromatin accessibility changes are associated with enhanced growth and liver metastasis capacity of acid-adapted colorectal cancer cells. Cell Cycle. 18:511–522. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Vymetalkova V, Vodicka P, Vodenkova S, Alonso S and Schneider-Stock R: DNA methylation and chromatin modifiers in colorectal cancer. Mol Aspects Med. 69:73–92. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Uusi-Mäkelä J, Afyounian E, Tabaro F, Häkkinen T, Lussana A, Shcherban A, Annala N, Nurminen R, Kivinummi K, Tammela TLJ, et al: Chromatin accessibility analysis uncovers regulatory element landscape in prostate cancer progression. bioRxiv. 2020.

16 

Hankey W, Chen Z and Wang Q: Shaping chromatin states in prostate cancer by pioneer transcription factors. Cancer Res. 80:2427–2436. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Braadland PR and Urbanucci A: Chromatin reprogramming as an adaptation mechanism in advanced prostate cancer. Endocr Relat Cancer. 26:R211–R235. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Arase M, Tamura Y, Kawasaki N, Isogaya K, Nakaki R, Mizutani A, Tsutsumi S, Aburatani H, Miyazono K and Koinuma D: Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells. Sci Rep. 7:11662017. View Article : Google Scholar : PubMed/NCBI

19 

Rubbi CP and Milner J: p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J. 22:975–986. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW and Vogelstein B: Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 282:1497–1501. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Park JH, Choi Y, Song MJ, Park K, Lee JJ and Kim HP: Dynamic long-range chromatin interaction controls expression of IL-21 in CD4+ T Cells. J Immunol. 196:4378–4389. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Buenrostro JD, Wu B, Chang HY and Greenleaf WJ: ATAC-seq: A method for assaying chromatin accessibility genome-wide. Curr Protoc Mol Biol. 109:21.29.1–21.29.9. 2015. View Article : Google Scholar

23 

Li H and Durbin R: Fast and accurate long-read alignment with burrows-wheeler transform. Bioinformatics. 26:589–595. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G and Durbin R; 1000 Genome Project Data Processing Subgroup, : The sequence alignment/map format and SAMtools. Bioinformatics. 25:2078–2079. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Gaspar JM: Improved peak-calling with MACS2. bioRxiv. 2018.

26 

Ramirez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F and Manke T: deepTools2: A next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 44((W1)): W160–W165. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Quinlan AR: BEDTools: The Swiss-Army tool for genome feature analysis. Curr Protoc Bioinformatics. 47:11.12.1–34. 2014. View Article : Google Scholar

28 

Robinson JT, Thorvaldsdóttir H, Winckler W, Guttman M, Lander ES, Getz G and Mesirov JP: Integrative genomics viewer. Nat Biotechnol. 29:24–26. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M and Gingeras TR: STAR: Ultrafast universal RNA-seq aligner. Bioinformatics. 29:15–21. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Li B and Dewey CN: RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 12:3232011. View Article : Google Scholar : PubMed/NCBI

31 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

32 

Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR and Ma'ayan A: Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics. 14:1282013. View Article : Google Scholar : PubMed/NCBI

33 

Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, et al: Enrichr: A comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44((W1)): W90–W97. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Hientz K, Mohr A, Bhakta-Guha D and Efferth T: The role of p53 in cancer drug resistance and targeted chemotherapy. Oncotarget. 8:8921–8946. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Munawar U, Roth M, Barrio S, Wajant H, Siegmund D, Bargou RC, Kortüm KM and Stühmer T: Assessment of TP53 lesions for p53 system functionality and drug resistance in multiple myeloma using an isogenic cell line model. Sci Rep. 9:180622019. View Article : Google Scholar : PubMed/NCBI

36 

Miyamoto K, Nguyen KT, Allen GE, Jullien J, Kumar D, Otani T, Bradshaw CR, Livesey FJ, Kellis M and Gurdon JB: Chromatin accessibility impacts transcriptional reprogramming in oocytes. Cell Rep. 24:304–311. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Penalosa-Ruiz G, Bright AR, Mulder KW and Veenstra GJC: The interplay of chromatin and transcription factors during cell fate transitions in development and reprogramming. Biochim Biophys Acta Gene Regul Mech. 1862:1944072019. View Article : Google Scholar : PubMed/NCBI

38 

Matilainen O, Sleiman MSB, Quiros PM, Garcia SMDA and Auwerx J: The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress. Nat Commun. 8:18182017. View Article : Google Scholar : PubMed/NCBI

39 

Weaver IC, Korgan AC, Lee K, Wheeler RV, Hundert AS and Goguen D: Stress and the emerging roles of chromatin remodeling in signal integration and stable transmission of reversible phenotypes. Front Behav Neurosci. 11:412017. View Article : Google Scholar : PubMed/NCBI

40 

Fischer M: Census and evaluation of p53 target genes. Oncogene. 36:3943–3956. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Andrysik Z, Galbraith MD, Guarnieri AL, Zaccara S, Sullivan KD, Pandey A, MacBeth M, Inga A and Espinosa JM: Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Genome Res. 27:1645–1657. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Younger ST and Rinn JL: p53 regulates enhancer accessibility and activity in response to DNA damage. Nucleic Acids Res. 45:9889–9900. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Angel P and Karin M: The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1072:129–157. 1991.PubMed/NCBI

44 

Eferl R and Wagner EF: AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer. 3:859–868. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Podar K, Raab MS, Tonon G, Sattler M, Barilà D, Zhang J, Tai YT, Yasui H, Raje N, DePinho RA, et al: Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Res. 67:1680–1688. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Bossy-Wetzel E, Bakiri L and Yaniv M: Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16:1695–1709. 1997. View Article : Google Scholar : PubMed/NCBI

47 

Stik G, Vidal E, Barrero M, Cuartero S, Vila-Casadesús M, Mendieta-Esteban J, Tian TV, Choi J, Berenguer C, Abad A, et al: CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response. Nat Genet. 52:655–661. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA and Donehower LA: Effects of TP53 mutational status on gene expression patterns across 10 human cancer types. J Pathol. 232:522–533. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Herrero AB, Rojas EA, Misiewicz-Krzeminska I, Krzeminski P and Gutierrez NC: Molecular mechanisms of p53 deregulation in cancer: An overview in multiple myeloma. Int J Mol Sci. 17:20032016. View Article : Google Scholar

50 

Shaulian E and Karin M: AP-1 in cell proliferation and survival. Oncogene. 20:2390–2400. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Obier N, Cauchy P, Assi SA, Gilmour J, Lie-A-Ling M, Lichtinger M, Hoogenkamp M, Noailles L, Cockerill PN, Lacaud G, et al: Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate. Development. 143:4324–4340. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Gazon H, Barbeau B, Mesnard JM and Peloponese JM Jr: Hijacking of the AP-1 signaling pathway during development of ATL. Front Microbiol. 8:26862018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang CM, Kang M, Jung W, Joo J, Kim Y, Choi Y and Kim H: p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncol Lett 21: 226, 2021.
APA
Yang, C.M., Kang, M., Jung, W., Joo, J., Kim, Y., Choi, Y., & Kim, H. (2021). p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncology Letters, 21, 226. https://doi.org/10.3892/ol.2021.12487
MLA
Yang, C. M., Kang, M., Jung, W., Joo, J., Kim, Y., Choi, Y., Kim, H."p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer". Oncology Letters 21.3 (2021): 226.
Chicago
Yang, C. M., Kang, M., Jung, W., Joo, J., Kim, Y., Choi, Y., Kim, H."p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer". Oncology Letters 21, no. 3 (2021): 226. https://doi.org/10.3892/ol.2021.12487
Copy and paste a formatted citation
x
Spandidos Publications style
Yang CM, Kang M, Jung W, Joo J, Kim Y, Choi Y and Kim H: p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncol Lett 21: 226, 2021.
APA
Yang, C.M., Kang, M., Jung, W., Joo, J., Kim, Y., Choi, Y., & Kim, H. (2021). p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncology Letters, 21, 226. https://doi.org/10.3892/ol.2021.12487
MLA
Yang, C. M., Kang, M., Jung, W., Joo, J., Kim, Y., Choi, Y., Kim, H."p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer". Oncology Letters 21.3 (2021): 226.
Chicago
Yang, C. M., Kang, M., Jung, W., Joo, J., Kim, Y., Choi, Y., Kim, H."p53 expression confers sensitivity to 5‑fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer". Oncology Letters 21, no. 3 (2021): 226. https://doi.org/10.3892/ol.2021.12487
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team