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An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer

  • Authors:
    • Riccardo Giampieri
    • Luca Cantini
    • Michela Del Prete
    • Alessandro Bittoni
    • Enrica Giglio
    • Alessandra Mandolesi
    • Elena Maccaroni
    • Andrea Lanese
    • Tania Meletani
    • Maria Giuditta Baleani
    • Renato Bisonni
    • Marina Scarpelli
    • Rossana Berardi
  • View Affiliations / Copyright

    Affiliations: Clinical Oncology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, I‑60126 Ancona, Italy, Medical Oncology, Azienda Ospedaliera di Fermo, I‑63900 Fermo, Italy, Clinical Oncology, Ospedali Riuniti Ancona, I‑60126 Ancona, Italy, Pathology, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, I‑60126 Ancona, Italy
    Copyright: © Giampieri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 267
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    Published online on: February 9, 2021
       https://doi.org/10.3892/ol.2021.12528
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Abstract

Despite novel drugs, the prognosis for patients with metastatic gastric cancer remains poor. In rare instances, locoregional therapies are used in addition to standard chemotherapy in patients with oligometastatic involvement. This type of approach has not been supported by solid published evidence. The aim of the present retrospective study was to assess the prognostic impact of factors such as metastatic site, tumour histology and locoregional treatment in patients with metastatic gastric cancer. A total of 184 patients with metastatic gastric or gastroesophageal junction adenocarcinoma who received at least one line of palliative therapy with doublet or triplet chemotherapy were enrolled in the current analysis. Median overall survival (OS) was 8.32 months (95% CI, 7.02‑9.41) and median progression‑free survival (PFS) was 4.16 months (95% CI, 3.24‑5.08). Lung metastases vs. other sites of metastatic involvement [hazard ratio (HR), 0.27; P=0.0133] and intestinal histology (HR, 0.48; P=0.08) were significantly associated with an improved OS. Improved PFS was also observed (HR, 0.49; P=0.10 and HR, 0.72; P=0.08 for lung metastases and intestinal histology, respectively). Second line chemotherapy and locoregional treatment of metastases (surgery or radiotherapy) were associated with improved OS (HR, 0.52; P<0.0001 and HR, 0.35; P<0.0001, respectively). Multivariate analysis confirmed an independent prognostic role for OS only for locoregional treatment, second line treatment and intestinal histology. The present results suggested that the presence of lung metastases alone was not a relevant prognostic factor and was influenced by the availability of further lines of treatment or by locoregional treatments. Locoregional treatments in patients with oligometastatic disease should be offered as they allow prolonged survival in patients with otherwise relatively short life expectancy.
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Copy and paste a formatted citation
Spandidos Publications style
Giampieri R, Cantini L, Del Prete M, Bittoni A, Giglio E, Mandolesi A, Maccaroni E, Lanese A, Meletani T, Baleani MG, Baleani MG, et al: An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer. Oncol Lett 21: 267, 2021.
APA
Giampieri, R., Cantini, L., Del Prete, M., Bittoni, A., Giglio, E., Mandolesi, A. ... Berardi, R. (2021). An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer. Oncology Letters, 21, 267. https://doi.org/10.3892/ol.2021.12528
MLA
Giampieri, R., Cantini, L., Del Prete, M., Bittoni, A., Giglio, E., Mandolesi, A., Maccaroni, E., Lanese, A., Meletani, T., Baleani, M. G., Bisonni, R., Scarpelli, M., Berardi, R."An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer". Oncology Letters 21.4 (2021): 267.
Chicago
Giampieri, R., Cantini, L., Del Prete, M., Bittoni, A., Giglio, E., Mandolesi, A., Maccaroni, E., Lanese, A., Meletani, T., Baleani, M. G., Bisonni, R., Scarpelli, M., Berardi, R."An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer". Oncology Letters 21, no. 4 (2021): 267. https://doi.org/10.3892/ol.2021.12528
Copy and paste a formatted citation
x
Spandidos Publications style
Giampieri R, Cantini L, Del Prete M, Bittoni A, Giglio E, Mandolesi A, Maccaroni E, Lanese A, Meletani T, Baleani MG, Baleani MG, et al: An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer. Oncol Lett 21: 267, 2021.
APA
Giampieri, R., Cantini, L., Del Prete, M., Bittoni, A., Giglio, E., Mandolesi, A. ... Berardi, R. (2021). An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer. Oncology Letters, 21, 267. https://doi.org/10.3892/ol.2021.12528
MLA
Giampieri, R., Cantini, L., Del Prete, M., Bittoni, A., Giglio, E., Mandolesi, A., Maccaroni, E., Lanese, A., Meletani, T., Baleani, M. G., Bisonni, R., Scarpelli, M., Berardi, R."An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer". Oncology Letters 21.4 (2021): 267.
Chicago
Giampieri, R., Cantini, L., Del Prete, M., Bittoni, A., Giglio, E., Mandolesi, A., Maccaroni, E., Lanese, A., Meletani, T., Baleani, M. G., Bisonni, R., Scarpelli, M., Berardi, R."An observational retrospective analysis of the main metastatic site and corresponding locoregional treatment as a prognostic factor in metastatic gastric cancer". Oncology Letters 21, no. 4 (2021): 267. https://doi.org/10.3892/ol.2021.12528
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