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Review Open Access

Advances in research on the regulatory mechanism of NHE1 in tumors (Review)

  • Authors:
    • Yanxia Hu
    • Jun Lou
    • Zhe Jin
    • Xiaoxu Yang
    • Weixi Shan
    • Qian Du
    • Qiushi Liao
    • Jingyu Xu
    • Rui Xie
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 273
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    Published online on: February 10, 2021
       https://doi.org/10.3892/ol.2021.12534
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Abstract

Tumors pose a major threat to human health and present with difficulties that modern medicine has yet to overcome. It has been demonstrated that the acid‑base balance of the tumor microenvironment is closely associated with the dynamic balance in the human body and that it regulates several processes, such as cell proliferation and differentiation, intracellular enzyme activity, and cytoskeletal assembly and depolymerization. It has been well established that the regulation of intra‑ and extracellular pH depends on a series of functional ion transporters and hydrogen ion channels, such as the Na+/H+ exchanger (NHE) protein and thee Cl/HCO3‑ exchange protein, among which the NHE1 member of the NHE family has been attracting increasing attention in recent years, particularly in studies on the correlation between pH regulation and tumors. NHE1 is a housekeeping gene encoding a protein that is widely expressed on the surface of all plasma membranes. Due to its functional domain, which determines the pHi at its N‑terminus and C‑terminus, NHE1 is involved in the regulation of the cellular pH microenvironment. It has been reported in the literature that NHE1 can regulate cell volume, participate in the transmembrane transport of intracellular and extracellular ions, affect cell proliferation and apoptosis, and regulate cell behavior and cell cycle progression; however, research on the role of NHE1 in tumorigenesis and tumor development in various systems is at its early stages. The aim of the present study was to review the current research on the correlation between the NHE family proteins and various systemic tumors, in order to indicate a new direction for antitumor drug development with the pH microenvironment as the target.
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Copy and paste a formatted citation
Spandidos Publications style
Hu Y, Lou J, Jin Z, Yang X, Shan W, Du Q, Liao Q, Xu J and Xie R: Advances in research on the regulatory mechanism of NHE1 in tumors (Review). Oncol Lett 21: 273, 2021.
APA
Hu, Y., Lou, J., Jin, Z., Yang, X., Shan, W., Du, Q. ... Xie, R. (2021). Advances in research on the regulatory mechanism of NHE1 in tumors (Review). Oncology Letters, 21, 273. https://doi.org/10.3892/ol.2021.12534
MLA
Hu, Y., Lou, J., Jin, Z., Yang, X., Shan, W., Du, Q., Liao, Q., Xu, J., Xie, R."Advances in research on the regulatory mechanism of NHE1 in tumors (Review)". Oncology Letters 21.4 (2021): 273.
Chicago
Hu, Y., Lou, J., Jin, Z., Yang, X., Shan, W., Du, Q., Liao, Q., Xu, J., Xie, R."Advances in research on the regulatory mechanism of NHE1 in tumors (Review)". Oncology Letters 21, no. 4 (2021): 273. https://doi.org/10.3892/ol.2021.12534
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Y, Lou J, Jin Z, Yang X, Shan W, Du Q, Liao Q, Xu J and Xie R: Advances in research on the regulatory mechanism of NHE1 in tumors (Review). Oncol Lett 21: 273, 2021.
APA
Hu, Y., Lou, J., Jin, Z., Yang, X., Shan, W., Du, Q. ... Xie, R. (2021). Advances in research on the regulatory mechanism of NHE1 in tumors (Review). Oncology Letters, 21, 273. https://doi.org/10.3892/ol.2021.12534
MLA
Hu, Y., Lou, J., Jin, Z., Yang, X., Shan, W., Du, Q., Liao, Q., Xu, J., Xie, R."Advances in research on the regulatory mechanism of NHE1 in tumors (Review)". Oncology Letters 21.4 (2021): 273.
Chicago
Hu, Y., Lou, J., Jin, Z., Yang, X., Shan, W., Du, Q., Liao, Q., Xu, J., Xie, R."Advances in research on the regulatory mechanism of NHE1 in tumors (Review)". Oncology Letters 21, no. 4 (2021): 273. https://doi.org/10.3892/ol.2021.12534
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