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Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer

  • Authors:
    • Shintaro Goto
    • Hiroko Seino
    • Tadashi Yoshizawa
    • Satoko Morohashi
    • Keinosuke Ishido
    • Kenichi Hakamada
    • Hiroshi Kijima
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Radiology, Aomori National Hospital, Namioka, Aomori 038‑1331, Japan, Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
    Copyright: © Goto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 276
    |
    Published online on: February 10, 2021
       https://doi.org/10.3892/ol.2021.12537
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an infiltrative growth pattern with intense desmoplastic stroma comprised of cancer‑associated fibroblasts (CAFs). Additionally, the histological characteristics are considered to play a vital role in the poor prognosis of PDAC. However, the density of cancer cells, degree of desmoplasia and vascular proliferation varies in individual cases. We hypothesized that preoperative radiological images would reflect histological characteristics, such as cancer cell density, CAF density and microvessel density. To clarify the association between the histological characteristics and radiological images of PDAC, the cancer cell density, CAF density and microvessel density from surgical specimens were measured with immunostaining, and the time density curve of dynamic contrast‑enhanced computed tomography (CECT) was analyzed. Overall, the initial slope between non‑enhanced and arterial phases was correlated with microvessel density, and the second slope between arterial and portal phases was correlated with CAF and cancer cell densities. In conclusion, the present study suggested the possibility of estimating cancer cell, CAF and microvessel densities using the TDC of dynamic CECT.
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1 

Stathis A and Moore MJ: Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol. 7:163–172. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Ilic M and Ilic I: Epidemiology of pancreatic cancer. World J Gastroenterol. 22:9694–9705. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Feig C, Gopinathan A, Neesse A, Chan DS, Cook N and Tuveson DA: The pancreas histological characteristics. Clin Cancer Res. 18:4266–4276. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Kobayashi H, Enomoto A, Woods SL, Burt AD, Takahashi M and Worthley DL: Cancer-associated fibroblasts in gastrointestinal cancer. Nat Rev Gastroenterol Hepatol. 16:282–295. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Kalluri R: The biology and function of fibroblasts in cancer. Nat Rev Cancer. 16:582–598. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Neesse A, Bauer CA, Öhlund D, Lauth M, Buchholz M, Michl P, Tuveson DA and Gress TM: Stromal biology and therapy in pancreatic cancer: Ready for clinical translation? Gut. 68:159–171. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Öhlund D, Elyada E and Tuveson D: Fibroblast heterogeneity in the cancer wound. J Exp Med. 211:1503–1523. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Gieniec KA, Butler LM, Worthley DL and Woods SL: Cancer-associated fibroblasts-heroes or villains? Br J Cancer. 121:293–302. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Ishii G, Ochiai A and Neri S: Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment. Adv Drug Deliv Rev. 99:186–196. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Mezawa Y and Orimo A: The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell Tissue Res. 365:675–689. 2016. View Article : Google Scholar : PubMed/NCBI

12 

El Khouli RH, Macura KJ, Kamel IR, Jacobs MA and Bluemke DA: 3-T dynamic contrast-enhanced MRI of the breast: Pharmacokinetic parameters versus conventional kinetic curve analysis. AJR Am J Roentgenol. 197:1498–1505. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Yang SN, Li FJ, Chen JM, Zhang G, Liao YH and Huang TC: Kinetic curve type assessment for classification of breast lesions using dynamic contrast-enhanced MR imaging. PLoS One. 11:e01528272016. View Article : Google Scholar : PubMed/NCBI

14 

Jabbar SB, Lynch B, Seiler S, Hwang H and Sahoo S: Pathologic findings of breast lesions detected on magnetic resonance imaging. Arch Pathol Lab Med. 141:1513–1522. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Hattori Y, Gabata T, Matsui O, Mochizuki K, Kitagawa H, Kayahara M, Ohta T and Nakanuma Y: Enhancement patterns of pancreatic adenocarcinoma on conventional dynamic multi-detector row CT: Correlation with angiogenesis and fibrosis. World J Gastroenterol. 15:3114–3121. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Brierley JD, Gospodarowicz MK and Wittekind C: The TNM classification of malignant tumours, 8th edition. Wiley Blackwell; Oxford: pp. 93–95. 2017

17 

WHO Classification of Tumours Editorial Board. WHO classification of tumours of the digestive system. IARC Press; Lyon: pp. 322–332. 2019

18 

Inoue C, Miki Y, Saito R, Hata S, Abe J, Sato I, Okada Y and Sasano H: PD-L1 induction by cancer-associated fibroblast-derived factors in lung adenocarcinoma cells. Cancers (Basel). 11:12572019. View Article : Google Scholar

19 

Itou RA, Uyama N, Hirota S, Kawada N, Wu S, Miyashita S, Nakamura I, Suzumura K, Sueoka H, Okada T, et al: Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma. Hum Pathol. 83:77–89. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Zhang J, Li S, Zhao Y, Ma P, Cao Y, Liu C, Zhang X, Wang W, Chen L and Li Y: Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling. Ann Transl Med. 8:8772020. View Article : Google Scholar : PubMed/NCBI

21 

Amornsupak K, Jamjuntra P, Warnnissorn M, O-Charoenrat P, Sa-Nguanraksa D, Thuwajit P, Eccles SA and Thuwajit C: High ASMA+ fibroblasts and low cytoplasmic HMGB1+ breast cancer cells predict poor prognosis. Clin Breast Cancer. 17:441–452.e2. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, et al: Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Commun. 394:947–954. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Yi CA, Lee KS, Kim EA, Han J, Kim H, Kwon OJ, Jeong YJ and Kim S: Solitary pulmonary nodules: Dynamic enhanced multi-detector row CT study and comparison with vascular endothelial growth factor and microvessel density. Radiology. 233:191–199. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Wang JH, Min PQ, Wang PJ, Cheng WX, Zhang XH, Wang Y, Zhao XH and Mao XQ: Dynamic CT evaluation of tumor vascularity in renal cell carcinoma. AJR Am J Roentgenol. 186:1423–1430. 2006. View Article : Google Scholar : PubMed/NCBI

25 

El-Gohary YM, Metwally G, Saad RS, Robinson MJ, Mesko T and Poppiti RJ: Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas. Am J Clin Pathol. 129:578–586. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Nieto Y, Woods J, Nawaz F, Baron A, Jones RB, Shpall EJ and Nawaz S: Prognostic analysis of tumour angiogenesis, determined by microvessel density and expression of vascular endothelial growth factor, in high-risk primary breast cancer patients treated with high-dose chemotherapy. Br J Cancer. 97:391–397. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Macchiarini P, Fontanini G, Hardin MJ, Squartini F and Angeletti CA: Relation of neovascularisation to metastasis of nonsmall-cell lung cancer. Lancet. 340:145–146. 1992. View Article : Google Scholar : PubMed/NCBI

29 

Fontanini G, Lucchi M, Vignati S, Mussi A, Ciardiello F, De Laurentiis M, De Placido S, Basolo F, Angeletti CA and Bevilacqua G: Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: A prospective study. J Natl Cancer Inst. 89:881–886. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Vermeulen PB, Van den Eynden GG, Huget P, Goovaerts G, Weyler J, Lardon F, Van Marck E, Hubens G and Dirix LY: Prospective study of intratumoral microvessel density, p53 expression and survival in colorectal cancer. Br J Cancer. 79:316–322. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Katsuta E, Qi Q, Peng X, Hochwald SN, Yan L and Takabe K: Pancreatic adenocarcinomas with mature blood vessels have better overall survival. Sci Rep. 9:13102019. View Article : Google Scholar : PubMed/NCBI

32 

Awai K and Date S: Basic knowledge to achieve optimal enhancement of CT. Nichidoku Iho. 56:13–32. 2011.

33 

Tsujino T, Seshimo I, Yamamoto H, Ngan CY, Ezumi K, Takemasa I, Ikeda M, Sekimoto M, Matsuura N and Monden M: Stromal myofibroblasts predict disease recurrence for colorectal cancer. Clin Cancer Res. 13:2082–2090. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Wang LM, Silva MA, D'Costa Z, Bockelmann R, Soonawalla Z, Liu S, O'Neill E, Mukherjee S, McKenna WG, Muschel R and Fokas E: The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget. 7:4183–4194. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Miyai Y, Esaki N, Takahashi M and Enomoto A: Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives. Cancer Sci. 111:1047–1057. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Alcaraz J, Carrasco JL, Millares L, Luis IC, Fernández-Porras FJ, Martínez-Romero A, Diaz-Valdivia N, De Cos JS, Rami-Porta R, Seijo L, et al: Stromal markers of activated tumor associated fibroblasts predict poor survival and are associated with necrosis in non-small cell lung cancer. Lung Cancer. 135:151–160. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, et al: Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis. Cancer Res. 79:5367–5381. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Goto S, Seino H, Yoshizawa T, Morohashi S, Ishido K, Hakamada K and Kijima H: Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer. Oncol Lett 21: 276, 2021.
APA
Goto, S., Seino, H., Yoshizawa, T., Morohashi, S., Ishido, K., Hakamada, K., & Kijima, H. (2021). Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer. Oncology Letters, 21, 276. https://doi.org/10.3892/ol.2021.12537
MLA
Goto, S., Seino, H., Yoshizawa, T., Morohashi, S., Ishido, K., Hakamada, K., Kijima, H."Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer". Oncology Letters 21.4 (2021): 276.
Chicago
Goto, S., Seino, H., Yoshizawa, T., Morohashi, S., Ishido, K., Hakamada, K., Kijima, H."Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer". Oncology Letters 21, no. 4 (2021): 276. https://doi.org/10.3892/ol.2021.12537
Copy and paste a formatted citation
x
Spandidos Publications style
Goto S, Seino H, Yoshizawa T, Morohashi S, Ishido K, Hakamada K and Kijima H: Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer. Oncol Lett 21: 276, 2021.
APA
Goto, S., Seino, H., Yoshizawa, T., Morohashi, S., Ishido, K., Hakamada, K., & Kijima, H. (2021). Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer. Oncology Letters, 21, 276. https://doi.org/10.3892/ol.2021.12537
MLA
Goto, S., Seino, H., Yoshizawa, T., Morohashi, S., Ishido, K., Hakamada, K., Kijima, H."Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer". Oncology Letters 21.4 (2021): 276.
Chicago
Goto, S., Seino, H., Yoshizawa, T., Morohashi, S., Ishido, K., Hakamada, K., Kijima, H."Time density curve of dynamic contrast‑enhanced computed tomography correlates with histological characteristics of pancreatic cancer". Oncology Letters 21, no. 4 (2021): 276. https://doi.org/10.3892/ol.2021.12537
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