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Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer

  • Authors:
    • Sangmin Kim
    • Daeun You
    • Yisun Jeong
    • Sun Young Yoon
    • Sung A Kim
    • Jeong Eon Lee
  • View Affiliations / Copyright

    Affiliations: Department of Breast Cancer Center, Samsung Medical Center, Gangnam‑gu, Seoul 06351, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 294
    |
    Published online on: February 17, 2021
       https://doi.org/10.3892/ol.2021.12555
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Abstract

The platelet‑derived growth factor (PDGF) family, a complex and imperative group of proangiogenic factors, acts as strong cell growth chemokines and is essential for the progression of malignancy in humans. In the present study, it was observed that aberrant PDGFB expression is associated with survival rates in patients with estrogen receptor‑positive (ER+) breast cancer unlike other subtypes, including PDGFA, PDGFC and PDGFD. Accordingly, the effect of specific PDGF receptor (PDGFR) inhibitors on ER‑α+ breast cancer cells was investigated. To block the PDGF‑BB signaling pathway, PDGFR inhibitors (sunitinib or ponatinib) were employed. Sunitinib and ponatinib were found to arrest the cell cycle at the G0‑G1 phase. In addition, the two PDGFR inhibitors were revealed to significantly inhibit cell growth and decrease the expression of matrix metalloproteinase‑1, which is one of the metastasis‑related genes. Finally, the combined effects of the two PDGFR inhibitors with tamoxifen were investigated. The results demonstrated that the combination of two PDGFR inhibitors with tamoxifen inhibited the growth of cells more consistently, compared with the effect mediated by tamoxifen alone. Therefore, it is proposed that PDGFR inhibitors, including sunitinib and ponatinib, should be applied effectively to treat ER‑α+ breast cancer.
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1 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med. 339:1609–1618. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG), . Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet. 365:1687–1717. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Fredriksson L, Li H and Eriksson U: The PDGF family: Four gene products form five dimeric isoforms. Cytokine Growth Factor Rev. 15:197–204. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Ostman A: PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev. 15:275–286. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K and Eriksson U: PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat Cell Biol. 3:512–516. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Kazlauskas A: PDGFs and their receptors. Gene. 614:1–7. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Heldin CH, Ostman A and Rönnstrand L: Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1378:F79–F113. 1998.PubMed/NCBI

9 

Carvalho I, Milanezi F, Martins A, Reis RM and Schmitt F: Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res. 7:R788–R795. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Györffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q and Szallasi Z: An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 123:725–731. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Kim S, You D, Jeong Y, Yu J, Kim SW, Nam SJ and Lee JE: Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells. Phytomedicine. 50:43–49. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Jeon M, Han J, Nam SJ, Lee JE and Kim S: Elevated IL-1β expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone. Chem Biol Interact. 258:126–133. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, Hartman J, Religa P, Morikawa H, Ishii Y, et al: Pericyte-fibroblast transition promotes tumor growth and metastasis. Proc Natl Acad Sci USA. 113:E5618–E5627. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Kim S, Lee J, Oh SJ, Nam SJ and Lee JE: Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncol Rep. 34:1613–1619. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kim S, Lee J, Jeon M, Nam SJ and Lee JE: Elevated TGF-β1 and -β2 expression accelerates the epithelial to mesenchymal transition in triple-negative breast cancer cells. Cytokine. 75:151–158. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K and Ostman A: Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol. 175:334–341. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Dai X, Cheng H, Bai Z and Li J: Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping. J Cancer. 8:3131–3141. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Stetler-Stevenson WG, Aznavoorian S and Liotta LA: Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol. 9:541–573. 1993. View Article : Google Scholar : PubMed/NCBI

19 

McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, Bucana C and Ellis LM: Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest. 117:2114–2122. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Nakamura Y, Tanaka F, Yoshikawa Y, Mimori K, Inoue H, Yanaga K and Mori M: PDGF-BB is a novel prognostic factor in colorectal cancer. Ann Surg Oncol. 15:2129–2136. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Er P, Qian D, Zhang W, Zhang B, Wei H, Zhang T, Chen X, Wang Y, Zhao J, Wang Q, et al: The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy. Aging (Albany NY). 12:6586–6599. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Fingas CD, Bronk SF, Werneburg NW, Mott JL, Guicciardi ME, Cazanave SC, Mertens JC, Sirica AE and Gores GJ: Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Hepatology. 54:2076–2088. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Wang JC, Li GY, Wang B, Han SX, Sun X, Jiang YN, Shen YW, Zhou C, Feng J, Lu SY, et al: Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation. J Exp Clin Cancer Res. 38:2352019. View Article : Google Scholar : PubMed/NCBI

24 

Wang KJ, Wang C, Dai LH, Yang J, Huang H, Ma XJ, Zhou Z, Yang ZY, Xu WD, Hua MM, et al: Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer. Clin Cancer Res. 25:1070–1086. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Donovan M, Cordon-Cardo C, Beug H and Grünert S: Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest. 116:1561–1570. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Greco C, D'Agnano I, Vitelli G, Vona R, Marino M, Mottolese M, Zuppi C, Capoluongo E and Ameglio F: c-MYC deregulation is involved in melphalan resistance of multiple myeloma: Role of PDGF-BB. Int J Immunopathol Pharmacol. 19:67–79. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Cumpănas AA, Cimpean AM, Ferician O, Ceausu RA, Sarb S, Barbos V, Dema A and Raica M: The Involvement of PDGF-B/PDGFRβ Axis in the Resistance to Antiangiogenic and Antivascular Therapy in Renal Cancer. Anticancer Res. 36:2291–2295. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim S, You D, Jeong Y, Yoon S, Kim S and Lee J: Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer. Oncol Lett 21: 294, 2021.
APA
Kim, S., You, D., Jeong, Y., Yoon, S., Kim, S., & Lee, J. (2021). Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer. Oncology Letters, 21, 294. https://doi.org/10.3892/ol.2021.12555
MLA
Kim, S., You, D., Jeong, Y., Yoon, S., Kim, S., Lee, J."Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer". Oncology Letters 21.4 (2021): 294.
Chicago
Kim, S., You, D., Jeong, Y., Yoon, S., Kim, S., Lee, J."Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer". Oncology Letters 21, no. 4 (2021): 294. https://doi.org/10.3892/ol.2021.12555
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, You D, Jeong Y, Yoon S, Kim S and Lee J: Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer. Oncol Lett 21: 294, 2021.
APA
Kim, S., You, D., Jeong, Y., Yoon, S., Kim, S., & Lee, J. (2021). Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer. Oncology Letters, 21, 294. https://doi.org/10.3892/ol.2021.12555
MLA
Kim, S., You, D., Jeong, Y., Yoon, S., Kim, S., Lee, J."Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer". Oncology Letters 21.4 (2021): 294.
Chicago
Kim, S., You, D., Jeong, Y., Yoon, S., Kim, S., Lee, J."Inhibition of platelet‑derived growth factor receptor synergistically increases the pharmacological effect of tamoxifen in estrogen receptor α positive breast cancer". Oncology Letters 21, no. 4 (2021): 294. https://doi.org/10.3892/ol.2021.12555
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