Open Access

Organoid research in digestive system tumors (Review)

  • Authors:
    • Xiaoxiao Yang
    • Xuewen Xu
    • Haitao Zhu
    • Ming Wang
    • Dongqing Wang
  • View Affiliations

  • Published online on: February 21, 2021     https://doi.org/10.3892/ol.2021.12569
  • Article Number: 308
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Digestive system tumors are the most common cause of cancer‑associated mortality worldwide, although their underlying biological behavior still requires further investigation. Most of the in vitro studies that have been published have been based on the two‑dimensional (2D) culture system. However, digestive system tumors exhibit considerable histological and functional heterogeneity, and clonal diversity and heterogeneity cannot be entirely reflected in the 2D culture system. Recently, the development of organoids appears to have shed some light on this area of cancer research. The present review discusses the recent advancements that have been made in the development of several specific organoids in digestive system solid tumors.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang X, Xu X, Zhu H, Wang M and Wang D: Organoid research in digestive system tumors (Review). Oncol Lett 21: 308, 2021
APA
Yang, X., Xu, X., Zhu, H., Wang, M., & Wang, D. (2021). Organoid research in digestive system tumors (Review). Oncology Letters, 21, 308. https://doi.org/10.3892/ol.2021.12569
MLA
Yang, X., Xu, X., Zhu, H., Wang, M., Wang, D."Organoid research in digestive system tumors (Review)". Oncology Letters 21.4 (2021): 308.
Chicago
Yang, X., Xu, X., Zhu, H., Wang, M., Wang, D."Organoid research in digestive system tumors (Review)". Oncology Letters 21, no. 4 (2021): 308. https://doi.org/10.3892/ol.2021.12569