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Review Open Access

Organoid research in digestive system tumors (Review)

  • Authors:
    • Xiaoxiao Yang
    • Xuewen Xu
    • Haitao Zhu
    • Ming Wang
    • Dongqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212031, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 308
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    Published online on: February 21, 2021
       https://doi.org/10.3892/ol.2021.12569
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Abstract

Digestive system tumors are the most common cause of cancer‑associated mortality worldwide, although their underlying biological behavior still requires further investigation. Most of the in vitro studies that have been published have been based on the two‑dimensional (2D) culture system. However, digestive system tumors exhibit considerable histological and functional heterogeneity, and clonal diversity and heterogeneity cannot be entirely reflected in the 2D culture system. Recently, the development of organoids appears to have shed some light on this area of cancer research. The present review discusses the recent advancements that have been made in the development of several specific organoids in digestive system solid tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Xu X, Zhu H, Wang M and Wang D: Organoid research in digestive system tumors (Review). Oncol Lett 21: 308, 2021.
APA
Yang, X., Xu, X., Zhu, H., Wang, M., & Wang, D. (2021). Organoid research in digestive system tumors (Review). Oncology Letters, 21, 308. https://doi.org/10.3892/ol.2021.12569
MLA
Yang, X., Xu, X., Zhu, H., Wang, M., Wang, D."Organoid research in digestive system tumors (Review)". Oncology Letters 21.4 (2021): 308.
Chicago
Yang, X., Xu, X., Zhu, H., Wang, M., Wang, D."Organoid research in digestive system tumors (Review)". Oncology Letters 21, no. 4 (2021): 308. https://doi.org/10.3892/ol.2021.12569
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Xu X, Zhu H, Wang M and Wang D: Organoid research in digestive system tumors (Review). Oncol Lett 21: 308, 2021.
APA
Yang, X., Xu, X., Zhu, H., Wang, M., & Wang, D. (2021). Organoid research in digestive system tumors (Review). Oncology Letters, 21, 308. https://doi.org/10.3892/ol.2021.12569
MLA
Yang, X., Xu, X., Zhu, H., Wang, M., Wang, D."Organoid research in digestive system tumors (Review)". Oncology Letters 21.4 (2021): 308.
Chicago
Yang, X., Xu, X., Zhu, H., Wang, M., Wang, D."Organoid research in digestive system tumors (Review)". Oncology Letters 21, no. 4 (2021): 308. https://doi.org/10.3892/ol.2021.12569
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