Deciphering the structure, function, expression and regulation of aquaporin‑5 in cancer evolution (Review)

  • Authors:
    • Liping Wang
    • Da Huo
    • Haiyan Zhu
    • Qian Xu
    • Chengpeng Gao
    • Wenfeng Chen
    • Yixiang Zhang
  • View Affiliations

  • Published online on: February 21, 2021     https://doi.org/10.3892/ol.2021.12571
  • Article Number: 309
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In recent years, the morbidity rate resulting from numerous types of malignant tumor has increased annually, and the treatment of tumors has been attracting an increasing amount of attention. A number of recent studies have revealed that the water channel protein aquaporin‑5 (AQP5) has become a major player in multiple types of cancer. AQP5 is abnormally expressed in a variety of tumor tissues or cells and has multiple effects on certain biological functions of tumors, such as regulating the proliferation, apoptosis and migration of tumor cells. It has been suggested that AQP5 may play an important role in the process of tumor development, opening up a new field of tumor research. The present review highlighted the structure of AQP5 and its role in tumor progression. Furthermore, the expression of AQP5 in different malignant neoplasms was summarized. In addition, the influence of not only drugs, but also different compounds on AQP5 were summarized. In conclusion, according to the findings in the present review, AQP5 has potential as a novel therapeutic target in human cancer, and other AQPs should be similarly investigated.
View Figures
View References

Related Articles

Journal Cover

April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Huo D, Zhu H, Xu Q, Gao C, Chen W and Zhang Y: Deciphering the structure, function, expression and regulation of aquaporin‑5 in cancer evolution (Review). Oncol Lett 21: 309, 2021
APA
Wang, L., Huo, D., Zhu, H., Xu, Q., Gao, C., Chen, W., & Zhang, Y. (2021). Deciphering the structure, function, expression and regulation of aquaporin‑5 in cancer evolution (Review). Oncology Letters, 21, 309. https://doi.org/10.3892/ol.2021.12571
MLA
Wang, L., Huo, D., Zhu, H., Xu, Q., Gao, C., Chen, W., Zhang, Y."Deciphering the structure, function, expression and regulation of aquaporin‑5 in cancer evolution (Review)". Oncology Letters 21.4 (2021): 309.
Chicago
Wang, L., Huo, D., Zhu, H., Xu, Q., Gao, C., Chen, W., Zhang, Y."Deciphering the structure, function, expression and regulation of aquaporin‑5 in cancer evolution (Review)". Oncology Letters 21, no. 4 (2021): 309. https://doi.org/10.3892/ol.2021.12571