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NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer

  • Authors:
    • Menglu Dong
    • Tao Xu
    • Xiaoqing Cui
    • Hanning Li
    • Xingrui Li
    • Wenfei Xia
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 323
    |
    Published online on: February 23, 2021
       https://doi.org/10.3892/ol.2021.12585
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Abstract

The role of non‑SMC condensin I complex subunit G (NCAPG) in breast cancer remains unclear. The present study used online databases, reverse transcription‑quantitative PCR, flow cytometry and western blotting to determine the expression levels, prognosis and potential molecular mechanisms underlying the role of NCAPG in breast cancer. The association between NCAPG expression and several different clinicopathological parameters in patients with breast cancer was determined, and the results revealed that NCAPG expression was negatively associated with estrogen receptor and progesterone receptor positive status, but was positively associated with HER2 positive status, Nottingham Prognostic Index score and Scarff‑Bloom‑Richardson grade status. Furthermore, upregulated expression levels of NCAPG resulted in a poor prognosis in patients with breast cancer. A total of 27 microRNAs (miRNAs/miRs) were predicted to target NCAPG, among which four miRNAs (miR‑101‑3p, miR‑195‑5p, miR‑214‑3p and miR‑944) were predicted to most likely regulate NCAPG expression in breast cancer. A total of 261 co‑expressed genes of NCAPG were identified, including cell division cyclin 25 homolog C (CDC25C), and pathway enrichment analysis indicated that these co‑expressed genes were significantly enriched in the p53 signaling pathway. CDC25C expression was downregulated in breast cancer and was associated with a poor prognosis. These findings suggested that upregulated NCAPG expression may be a prognostic biomarker of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Dong M, Xu T, Cui X, Li H, Li X and Xia W: NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer. Oncol Lett 21: 323, 2021.
APA
Dong, M., Xu, T., Cui, X., Li, H., Li, X., & Xia, W. (2021). NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer. Oncology Letters, 21, 323. https://doi.org/10.3892/ol.2021.12585
MLA
Dong, M., Xu, T., Cui, X., Li, H., Li, X., Xia, W."NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer". Oncology Letters 21.4 (2021): 323.
Chicago
Dong, M., Xu, T., Cui, X., Li, H., Li, X., Xia, W."NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer". Oncology Letters 21, no. 4 (2021): 323. https://doi.org/10.3892/ol.2021.12585
Copy and paste a formatted citation
x
Spandidos Publications style
Dong M, Xu T, Cui X, Li H, Li X and Xia W: NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer. Oncol Lett 21: 323, 2021.
APA
Dong, M., Xu, T., Cui, X., Li, H., Li, X., & Xia, W. (2021). NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer. Oncology Letters, 21, 323. https://doi.org/10.3892/ol.2021.12585
MLA
Dong, M., Xu, T., Cui, X., Li, H., Li, X., Xia, W."NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer". Oncology Letters 21.4 (2021): 323.
Chicago
Dong, M., Xu, T., Cui, X., Li, H., Li, X., Xia, W."NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer". Oncology Letters 21, no. 4 (2021): 323. https://doi.org/10.3892/ol.2021.12585
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