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Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome

  • Authors:
    • Amany M. Kamal
    • Nermeen A. Nabih
    • Nooran S. Elleboudy
    • Sara M. Radwan
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt, Department of Internal Medicine, Clinical Hematology and Bone Marrow Transplantation Unit, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt, Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
    Copyright: © Kamal et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 325
    |
    Published online on: February 24, 2021
       https://doi.org/10.3892/ol.2021.12587
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Abstract

Despite recent advancements in the therapeutic landscape of acute myeloid leukemia (AML), the prognosis of patients remains poor. Immune check point inhibitors have been investigated in hematological malignancies, including AML; however, the role of T‑cell immunoglobulin and mucin domain 3 (TIM‑3) in AML has not yet been fully elucidated. Thus, the present study aimed to investigate TIM‑3 gene expression in patients with AML and determine its associations with prognostic variables and clinical outcome. A total of 60 patients newly diagnosed with AML and 15 healthy matching individuals were recruited in the present study, and reverse transcription‑quantitative PCR analysis was performed to detect TIM‑3 expression. The results demonstrated that TIM‑3 expression was significantly upregulated in patients with AML compared with that in healthy individuals (P<0.001). In addition, patients with extramedullary disease (EMD) exhibited significantly lower median TIM‑3 expression levels compared with those without EMD (P=0.001). Furthermore, patients with high TIM‑3 expression had significantly lower complete remission rates following induction chemotherapy compared with those with low TIM‑3 expression (P=0.004). High TIM‑3 expression was significantly associated with lower overall survival rates during the 1‑year follow‑up (P=0.001). Taken together, the results of the present study suggest that TIM‑3 may act as a biomarker of a poor prognosis in patients with AML, and be used as a therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Kamal AM, Nabih NA, Elleboudy NS and Radwan SM: Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome. Oncol Lett 21: 325, 2021.
APA
Kamal, A.M., Nabih, N.A., Elleboudy, N.S., & Radwan, S.M. (2021). Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome. Oncology Letters, 21, 325. https://doi.org/10.3892/ol.2021.12587
MLA
Kamal, A. M., Nabih, N. A., Elleboudy, N. S., Radwan, S. M."Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome". Oncology Letters 21.4 (2021): 325.
Chicago
Kamal, A. M., Nabih, N. A., Elleboudy, N. S., Radwan, S. M."Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome". Oncology Letters 21, no. 4 (2021): 325. https://doi.org/10.3892/ol.2021.12587
Copy and paste a formatted citation
x
Spandidos Publications style
Kamal AM, Nabih NA, Elleboudy NS and Radwan SM: Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome. Oncol Lett 21: 325, 2021.
APA
Kamal, A.M., Nabih, N.A., Elleboudy, N.S., & Radwan, S.M. (2021). Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome. Oncology Letters, 21, 325. https://doi.org/10.3892/ol.2021.12587
MLA
Kamal, A. M., Nabih, N. A., Elleboudy, N. S., Radwan, S. M."Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome". Oncology Letters 21.4 (2021): 325.
Chicago
Kamal, A. M., Nabih, N. A., Elleboudy, N. S., Radwan, S. M."Expression of immune check point gene TIM‑3 in patients newly diagnosed with acute myeloid leukemia: Significance and impact on outcome". Oncology Letters 21, no. 4 (2021): 325. https://doi.org/10.3892/ol.2021.12587
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