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MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway

  • Authors:
    • Xiaodan Han
    • Aili Li
    • Wei Wang
    • Longxia Du
    • Chen Wang
    • Guojin Huang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Respiratory Diseases, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 334
    |
    Published online on: February 25, 2021
       https://doi.org/10.3892/ol.2021.12595
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Abstract

Melanocyte proliferating gene 1 (MYG1) is an exonuclease that participates in RNA processing and is required for normal mitochondrial function. However, its role in tumorigenesis remains unknown. The present study aimed to investigate the role of MYG1 and its underlying mechanisms in human lung adenocarcinoma (LUAD). The expression levels of MYG1 in tumor tissues of patients with LUAD were obtained from public cancer databases and analyzed using the UALCAN online software. The association between MYG1 expression levels and the prognosis of patients with LUAD was analyzed using the Kaplan‑Meier plotter. In addition, the role of MYG1 in the LUAD A549 and H1993 cell lines was determined by knocking down MYG1 expression with a specific small interfering RNA or by overexpressing it with a MYG1‑containing plasmid. The results demonstrated that MYG1 expression levels were upregulated in LUAD tissues compared with those in normal lung tissues from healthy subjects, and high MYG1 expression levels were associated with an unfavorable prognosis. MYG1 promoted the proliferation, migration and invasion of A549 and H1993 cells. In addition, MYG1 inhibited autophagy via the AMP-activated protein kinase/mTOR complex 1 signaling pathway. Collectively, the present results suggested that MYG1 may serve an oncogenic role in LUAD and may be a potential therapeutic target for LUAD.
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Copy and paste a formatted citation
Spandidos Publications style
Han X, Li A, Wang W, Du L, Wang C and Huang G: MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway. Oncol Lett 21: 334, 2021.
APA
Han, X., Li, A., Wang, W., Du, L., Wang, C., & Huang, G. (2021). MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway. Oncology Letters, 21, 334. https://doi.org/10.3892/ol.2021.12595
MLA
Han, X., Li, A., Wang, W., Du, L., Wang, C., Huang, G."MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway". Oncology Letters 21.4 (2021): 334.
Chicago
Han, X., Li, A., Wang, W., Du, L., Wang, C., Huang, G."MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway". Oncology Letters 21, no. 4 (2021): 334. https://doi.org/10.3892/ol.2021.12595
Copy and paste a formatted citation
x
Spandidos Publications style
Han X, Li A, Wang W, Du L, Wang C and Huang G: MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway. Oncol Lett 21: 334, 2021.
APA
Han, X., Li, A., Wang, W., Du, L., Wang, C., & Huang, G. (2021). MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway. Oncology Letters, 21, 334. https://doi.org/10.3892/ol.2021.12595
MLA
Han, X., Li, A., Wang, W., Du, L., Wang, C., Huang, G."MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway". Oncology Letters 21.4 (2021): 334.
Chicago
Han, X., Li, A., Wang, W., Du, L., Wang, C., Huang, G."MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway". Oncology Letters 21, no. 4 (2021): 334. https://doi.org/10.3892/ol.2021.12595
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