Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma

  • Authors:
    • Cuong Minh Tran
    • Takeshi Kuroshima
    • Yu Oikawa
    • Yasuyuki Michi
    • Kou Kayamori
    • Hiroyuki Harada
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan, Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan
    Copyright: © Tran et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 339
    |
    Published online on: February 26, 2021
       https://doi.org/10.3892/ol.2021.12600
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pigmented oral squamous cell carcinoma (POSCC) is a rare and underrecognized pathological variant of oral squamous cell carcinoma (OSCC). The current study aimed to evaluate the clinicopathological characteristics, treatment outcomes and prognosis of patients with POSCC and to investigate its oncological properties using immunohistochemical studies. A total of 1,512 patients were pathologically diagnosed with squamous cell carcinoma of the oral cavity, and were treated at the Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University between January 2001 and December 2018. A total of 25 patients had POSCC and underwent radical surgery. Of these 25 patients, 23 presented with early T stage disease. Additionally, 22 patients were negative for cervical lymph nodes metastasis. Only one patient had local recurrence. The 5‑year disease‑free and disease‑specific survival rates were 86.6 and 95.8%, respectively. Immunohistochemically, a high percentage of POSCC exhibited low p53 and Ki‑67, preserved E‑cadherin or negative vimentin expression. The results suggested that POSCC tends to exhibit non‑aggressive oncological behavior and demonstrates a good prognosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Pulte D and Brenner H: Changes in survival in head and neck cancers in the late 20th and early 21st century: A period analysis. Oncologist. 15:994–1001. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Sim YC, Hwang JH and Ahn KM: Overall and disease-specific survival outcomes following primary surgery for oral squamous cell carcinoma: Analysis of consecutive 67 patients. J Korean Assoc Oral Maxillofac Surg. 45:83–90. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Iihara K, Yamaguchi K, Fujioka Y and Uno S: Pigmented neuroendocrine tumor of the lung, showing neuromelanin. Pathol Int. 52:734–739. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Zhang X, Liang Y and Wang HY: Invasive ductal carcinoma of the breast associated with extensive melanin melanosis: A case report and review of the literature. Int J Clin Exp Pathol. 7:1218–1223. 2014.PubMed/NCBI

6 

Takeda Y and Kurose A: Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors. J Oral Sci. 48:253–256. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Satter EK: Pigmented squamous cell carcinoma. Am J Dermatopathol. 29:486–489. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Masuzawa N, Kishimoto M and Takahashi Y: Pigmented squamous cell carcinoma of the uterine cervix. Int J Gynecol Pathol. 22:285–288. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Shields JA, Shields CL, Eagle RC Jr, Singh AD, Demirci H and Wolf MA: Pigmented conjunctival squamous cell carcinoma simulating a conjunctival melanoma. Am J Ophthalmol. 132:104–106. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Mathews A, Abraham EK, Amman S and Nair MK: Pigmented squamous cell carcinoma of nasal cavity. Histopathology. 33:184–185. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Matsumoto M, Sonobe H, Takeuchi T, Furihata M, Iwata J, Ikeda M and Ohtsuki Y: Pigmented squamous cell carcinoma of the scrotum associated with a lentigo. Br J Dermatol. 141:132–136. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Kamiya M, Maehara R, Iizuka S, Yoshida T, Yamanouchi H, Yokoo H, Sasaki A, Hirato J and Nakazato Y: Pigmented squamous cell carcinoma with dendritic melanocyte colonization in the external auditory canal. Pathol Int. 49:909–912. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Patakas B, Hecker R and Kramer HS: Report on an oral, pigmented, squamous cell carcinoma. Int J Oral Surg. 3:445–448. 1974. View Article : Google Scholar : PubMed/NCBI

14 

Ide F, Kusuhara S, Ohnuma H, Miyake T, Nakajima T and Kimura T: Pigmented squamous cell carcinoma of the oral mucosa - with special reference to the role of non-keratinocytes in tumors and tumorous conditions. J Nihon Univ Sch Dent. 23:1–9. 1981. View Article : Google Scholar : PubMed/NCBI

15 

Dunlap CL and Tomich CE: Melanocyte colonization of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol. 52:524–530. 1981. View Article : Google Scholar : PubMed/NCBI

16 

Modica LA, Youngberg GA and Avila FO: Melanocyte colonization of an oral carcinoma. Histopathology. 17:477–478. 1990. View Article : Google Scholar : PubMed/NCBI

17 

Kuwabara H, Uda H, Miyaguchi M, Nagai M, Saito K and Shibanushi T: Pigmented squamous cell carcinoma of the alveolar ridge in the oral mucosa. Oral Surg Oral Med Oral Pathol. 77:61–65. 1994. View Article : Google Scholar : PubMed/NCBI

18 

Satomura K, Tokuyama R, Yamasaki Y, Yuasa T, Tatehara S, Ishimaru N, Hayashi Y and Nagayama M: Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa. J Oral Pathol Med. 36:621–624. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Lisboa Castro J, Cazal C, Gomes Henriques AC, Carneiro Leão J, de Vasconcelos Carvalho M, de Carvalho Dourado HT and Carvalho AA: Pigmented oral squamous cell carcinoma: A case report and brief review of the literature. Int J Surg Pathol. 17:153–157. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Mikami T, Furuya I, Kumagai A, Furuuchi H, Hoshi H, Iijima S, Sugiyama Y and Takeda Y: Pigmented squamous cell carcinoma of oral mucosa: Clinicopathologic study of 3 cases. J Oral Maxillofac Surg. 70:1232–1239. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Matsumoto N, Kitano T, Oki H, Omagari D, Matsue Y, Okudera M, Yamamura T, Nishikawa Y, Nishimura S, Asano M, et al: Pigmented oral carcinoma in situ: A case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 118:e79–e83. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Martins F, Mistro FZ, Kignel S, Palmieri M, do Canto AM and Braz-Silva PH: Pigmented squamous cell carcinoma in situ: Report of a new case and review of the literature. J Clin Exp Dent. 9:e1362–e1365. 2017.PubMed/NCBI

23 

Zhou G, Liu Z and Myers JN: TP53 Mutations in head and neck squamous cell carcinoma and their impact on disease progression and treatment response. J Cell Biochem. 117:2682–2692. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Cutilli T, Leocata P, Dolo V and Altobelli E: p53 as a prognostic marker associated with the risk of mortality for oral squamous cell carcinoma. Oncol Lett. 12:1046–1050. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Xie S, Liu Y, Qiao X, Hua RX, Wang K, Shan XF and Cai ZG: What is the prognostic significance of Ki-67 positivity in oral squamous cell carcinoma? J Cancer. 7:758–767. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Wan Y, Liu H, Zhang M, Huang Z, Zhou H, Zhu Y, Tao Y, Xie N, Liu X, Hou J, et al: Prognostic value of epithelial-mesenchymal transition-inducing transcription factors in head and neck squamous cell carcinoma: A meta-analysis. Head Neck. 42:1067–1076. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours. John Wiley & Sons Ltd; West Sussex: pp. 3322010

28 

Anneroth G, Batsakis J and Luna M: Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res. 95:229–249. 1987.PubMed/NCBI

29 

Costa LC, Leite CF, Cardoso SV, Loyola AM, Faria PR, Souza PE and Horta MC: Expression of epithelial-mesenchymal transition markers at the invasive front of oral squamous cell carcinoma. J Appl Oral Sci. 23:169–178. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Shen H and Wu W: Study of melanin bleaching after immunohistochemistry of melanin-containing tissues. Appl Immunohistochem Mol Morphol. 23:303–307. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Yu CH, Chen HH, Liu CM, Jeng YM, Wang JT, Wang YP, Liu BY, Sun A and Chiang CP: HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas. J Oral Pathol Med. 34:540–545. 2005. View Article : Google Scholar : PubMed/NCBI

32 

De Silva RK, Siriwardena BSMS, Samaranayaka A, Abeyasinghe WAMUL and Tilakaratne WM: A model to predict nodal metastasis in patients with oral squamous cell carcinoma. PLoS One. 13:e02017552018. View Article : Google Scholar : PubMed/NCBI

33 

Abidullah M, Kiran G, Gaddikeri K, Raghoji S and Ravishankar TS: Leuloplakia - review of a potentially malignant disorder. J Clin Diagn Res. 8:ZE01–ZE04. 2014.PubMed/NCBI

34 

Hirobe T: Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Pigment Cell Res. 18:2–12. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Sharma M, Sah P, Sharma SS and Radhakrishnan R: Molecular changes in invasive front of oral cancer. J Oral Maxillofac Pathol. 17:240–247. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Li Y, Li B, Xu B, Han B, Xia H, Chen QM and Li LJ: Expression of p53, p21(CIP1/WAF1) and eIF4E in the adjacent tissues of oral squamous cell carcinoma: Establishing the molecular boundary and a cancer progression model. Int J Oral Sci. 7:161–168. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Varun BR, Ranganathan K, Rao UK and Joshua E: Immunohistochemical detection of p53 and p63 in oral squamous cell carcinoma, oral leukoplakia, and oral submucous fibrosis. J Investig Clin Dent. 5:214–219. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Swaminathan U, Joshua E, Rao UK and Ranganathan K: Expression of p53 and Cyclin D1 in oral squamous cell carcinoma and normal mucosa: An Immunohistochemical study. J Oral Maxillofac Pathol. 16:172–177. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Lavieille JP, Brambilla E, Riva-Lavieille C, Reyt E, Charachon R and Brambilla C: Immunohistochemical detection of p53 protein in preneoplastic lesions and squamous cell carcinoma of the head and neck. Acta Otolaryngol. 115:334–339. 1995. View Article : Google Scholar : PubMed/NCBI

40 

Nadal A, Campo E, Pinto J, Mallofré C, Palacín A, Arias C, Traserra J and Cardesa A: p53 expression in normal, dysplastic, and neoplastic laryngeal epithelium. Absence of a correlation with prognostic factors. J Pathol. 175:181–188. 1995. View Article : Google Scholar : PubMed/NCBI

41 

Tandon S, Tudur-Smith C, Riley RD, Boyd MT and Jones TM: A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck. Cancer Epidemiol Biomarkers Prev. 19:574–587. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Motta RR, Zettler CG, Cambruzzi E, Jotz GP and Berni RB: Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue. Rev Bras Otorrinolaringol (Engl Ed). 75:544–549. 2009.

43 

Liu S, Liu L, Ye W, Ye D, Wang T, Guo W, Liao Y, Xu D, Song H, Zhang L, et al: High vimentin expression associated with lymph node metastasis and predicated a poor prognosis in oral squamous cell carcinoma. Sci Rep. 6:388342016. View Article : Google Scholar : PubMed/NCBI

44 

Feller L, Masilana A, Khammissa RA, Altini M, Jadwat Y and Lemmer J: Melanin: The biophysiology of oral melanocytes and physiological oral pigmentation. Head Face Med. 10:82014. View Article : Google Scholar : PubMed/NCBI

45 

Plonka PM, Passeron T, Brenner M, Tobin DJ, Shibahara S, Thomas A, Slominski A, Kadekaro AL, Hershkovitz D, Peters E, et al: What are melanocytes really doing all day long…? Exp Dermatol. 18:799–819. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Nilima S and Vandana KL: Melanin: A scavenger in gingival inflammation. Indian J Dent Res. 22:38–43. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Choudhari SK, Chaudhary M, Gadbail AR, Sharma A and Tekade S: Oxidative and antioxidative mechanisms in oral cancer and precancer: A review. Oral Oncol. 50:10–18. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tran CM, Kuroshima T, Oikawa Y, Michi Y, Kayamori K and Harada H: Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma. Oncol Lett 21: 339, 2021.
APA
Tran, C.M., Kuroshima, T., Oikawa, Y., Michi, Y., Kayamori, K., & Harada, H. (2021). Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma. Oncology Letters, 21, 339. https://doi.org/10.3892/ol.2021.12600
MLA
Tran, C. M., Kuroshima, T., Oikawa, Y., Michi, Y., Kayamori, K., Harada, H."Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma". Oncology Letters 21.4 (2021): 339.
Chicago
Tran, C. M., Kuroshima, T., Oikawa, Y., Michi, Y., Kayamori, K., Harada, H."Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma". Oncology Letters 21, no. 4 (2021): 339. https://doi.org/10.3892/ol.2021.12600
Copy and paste a formatted citation
x
Spandidos Publications style
Tran CM, Kuroshima T, Oikawa Y, Michi Y, Kayamori K and Harada H: Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma. Oncol Lett 21: 339, 2021.
APA
Tran, C.M., Kuroshima, T., Oikawa, Y., Michi, Y., Kayamori, K., & Harada, H. (2021). Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma. Oncology Letters, 21, 339. https://doi.org/10.3892/ol.2021.12600
MLA
Tran, C. M., Kuroshima, T., Oikawa, Y., Michi, Y., Kayamori, K., Harada, H."Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma". Oncology Letters 21.4 (2021): 339.
Chicago
Tran, C. M., Kuroshima, T., Oikawa, Y., Michi, Y., Kayamori, K., Harada, H."Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma". Oncology Letters 21, no. 4 (2021): 339. https://doi.org/10.3892/ol.2021.12600
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team