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High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth

  • Authors:
    • Xinhui Huang
    • Yongping Lai
    • Na Yao
    • Yongliang Cui
    • Xiaoling Yu
    • Zhixiong Cai
    • Yupeng Tang
    • Yao Huang
    • Jinhua Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Invasive Technology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China, Department of Pharmacy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Hepatobiliary Technology Key Laboratory, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China
  • Article Number: 347
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    Published online on: March 3, 2021
       https://doi.org/10.3892/ol.2021.12608
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Abstract

Hepatocellular carcinoma (HCC) is a cancer with a poor prognosis and a low survival rate. Previous studies have found that microRNA‑1266 (miR‑1266) is associated with tumorigenesis and progression of several types of cancer, such as breast cancer and gastric cancer. The aim of the present study was to investigate the effects of miR‑1266 on the clinical prognosis and biological behavior of HCC. For this purpose, reverse transcription‑quantitative PCR was used to detect the expression of miR‑1266 in HCC tissues and HCC cell lines. In addition, Kaplan‑Meier survival analysis and Cox regression analysis were used to evaluate the prognostic value of miR‑1266. Cell Counting Kit‑8 (CCK‑8) and Transwell assays were used to analyze the effect of miR‑1266 on the biological behavior of cells. The aforementioned assays demonstrated that the examined HCC tissues had a significant upregulation of miR‑1266 expression compared with normal tissues (P<0.001). The overexpression of miR‑1266 was significantly associated with Tumor‑Node‑Metastasis stage (P=0.014). The results of the Kaplan‑Meier analysis indicated that the 5‑year overall survival rate of patients with high expression of miR‑1266 was significantly lower compared with patients with low expression of miR‑1266 (P=0.015). Cox regression analysis demonstrated that the expression level of miR‑1266 could be used as an independent prognostic factor of HCC. CCK‑8 and Transwell assays demonstrated that overexpression of miR‑1266 promoted the proliferation, migration and invasion of HCC cells. In summary, the findings of the present study indicated that high expression of miR‑1266 was positively associated with poor prognosis of patients with HCC and promoted cell proliferation, migration and invasion of HCC cells. miR‑1266 may be used as a biomarker for HCC prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Lai Y, Yao N, Cui Y, Yu X, Cai Z, Tang Y, Huang Y and Zeng J: High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth. Oncol Lett 21: 347, 2021.
APA
Huang, X., Lai, Y., Yao, N., Cui, Y., Yu, X., Cai, Z. ... Zeng, J. (2021). High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth. Oncology Letters, 21, 347. https://doi.org/10.3892/ol.2021.12608
MLA
Huang, X., Lai, Y., Yao, N., Cui, Y., Yu, X., Cai, Z., Tang, Y., Huang, Y., Zeng, J."High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth". Oncology Letters 21.5 (2021): 347.
Chicago
Huang, X., Lai, Y., Yao, N., Cui, Y., Yu, X., Cai, Z., Tang, Y., Huang, Y., Zeng, J."High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth". Oncology Letters 21, no. 5 (2021): 347. https://doi.org/10.3892/ol.2021.12608
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Lai Y, Yao N, Cui Y, Yu X, Cai Z, Tang Y, Huang Y and Zeng J: High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth. Oncol Lett 21: 347, 2021.
APA
Huang, X., Lai, Y., Yao, N., Cui, Y., Yu, X., Cai, Z. ... Zeng, J. (2021). High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth. Oncology Letters, 21, 347. https://doi.org/10.3892/ol.2021.12608
MLA
Huang, X., Lai, Y., Yao, N., Cui, Y., Yu, X., Cai, Z., Tang, Y., Huang, Y., Zeng, J."High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth". Oncology Letters 21.5 (2021): 347.
Chicago
Huang, X., Lai, Y., Yao, N., Cui, Y., Yu, X., Cai, Z., Tang, Y., Huang, Y., Zeng, J."High expression of microRNA‑1266 in hepatocellular carcinoma is associated with poor prognosis of patients and biological cell growth". Oncology Letters 21, no. 5 (2021): 347. https://doi.org/10.3892/ol.2021.12608
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