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Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China

  • Authors:
    • Jie Xing
    • Tao Tan
    • Yang-Long Guo
    • Jian-Qing Zhu
    • Ai-Wen Zheng
    • Ai-Jun Yu
    • Zheng Niu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310062, P.R. China, Department of Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310002, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 366
    |
    Published online on: March 10, 2021
       https://doi.org/10.3892/ol.2021.12627
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Abstract

Determining the spatial distribution of human papillomavirus (HPV) and performing accurate public health analyses helps to distinguish areas of healthcare that require further research, and enables therapeutic techniques and approaches in healthcare to be focused more accurately. A total of 4,560 women were enrolled in the present study. Flow‑through hybridization and gene chip assays were used to detect the genotypes of HPV infection. Heat maps were then generated to present the spatial distribution of HPV infections in Zhejiang Province according to genotype. Of the exfoliated cervical cell samples from the 4,560 women, HPV was detected in 1,886 samples. HPV‑16, ‑58, ‑52 and ‑18 were the most prevalently identified genotypes in the population included in the present study. HPV‑16 and ‑58 infections were mainly distributed in the northern and central regions of Zhejiang Province, such as in Hangzhou and Shaoxing, where the prevalence was higher than that in the southern regions (P<0.05). HPV‑18 infection was widespread throughout Zhejiang Province, but had a much lower infection rate in Ningbo and Huzhou (P<0.05). High infection rates of HPV‑52 were mainly detected in Hangzhou and the eastern coastal areas of Wenzhou, with a relatively low rate of infection in the center of the province (P<0.05). In conclusion, HPV‑16, ‑58, ‑52 and ‑18 were the four most prevalent HPV genotypes observed in Zhejiang Province. Heat maps were created to display the spatial distribution of HPV infection according to genotype, which varied by geographical regions. The results indicate that for individuals in Ningbo or Wenzhou, bivalent or quadrivalent vaccines may be suitable, but for those in Hangzhou and Shaoxing, nonavalent vaccines are strongly recommended.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Burchell AN, Winer RL, de Sanjosé S and Franco EL: Chapter 6: Epidemiology and transmission dynamics of genital HPV infection. Vaccine. 24 (Suppl 3):S3/52–61. 2006. View Article : Google Scholar

3 

Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, Snijders PJ and Meijer CJ; International Agency for Research on Cancer Multicenter Cervical Cancer Study Group, : Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 348:518–527. 2003. View Article : Google Scholar : PubMed/NCBI

4 

De Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, Tous S, Felix A, Bravo LE, Shin HR, et al: Human papillomavirus genotype attribution in invasive cervical cancer: A retrospective cross-sectional worldwide study. Lancet Oncol. 11:1048–1056. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Clifford GM, Gallus S, Herrero R, Muñoz N, Snijders PJ, Vaccarella S, Anh PT, Ferreccio C, Hieu NT, Matos E, et al: Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: A pooled analysis. Lancet. 366:991–998. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ and Muñoz N: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 189:12–19. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX and de Sanjosé S: Cervical human papillomavirus prevalence in 5 continents: Meta-analysis of 1 million women with normal cytological findings. J Infect Dis. 202:1789–1799. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Xu XX, Zhou JS, Yuan SH, Yu H and Lou HM: Distribution of HPV genotype in invasive cervical carcinoma and cervical intraepithelial neoplasiain zhejiang province, southeast China: Establishing the baseline for surveillance. Int J Environ Res Public Health. 12:10794–10805. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Huang S, Afonina I, Miller BA and Beckmann AM: Human papillomavirus types 52 and 58 are prevalent in cervical cancers from Chinese women. Int J Cancer. 70:408–411. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Lo KW, Wong YF, Chan MK, Li JC, Poon JS, Wang VW, Zhu SN, Zhang TM, He ZG, Wu QL, et al: Prevalence of human papillomavirus in cervical cancer: A multicenter study in China. Int J Cancer. 100:327–331. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Liu J, Rose B, Huang X, Liao G, Carter J, Wu X and Thompson C: Comparative analysis of characteristics of women with cervical cancer in high-versus low-incidence regions. Gynecol Oncol. 94:803–810. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Requia WJ, Roig HL, Adams MD, Zanobetti A and Koutrakis P: Mapping distance-decay of cardiorespiratory disease risk related to neighborhood environments. Environ Res. 151:203–215. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Svendsen ER, Gonzales M, Mukerjee S, Smith L, Ross M, Walsh D, Rhoney S, Andrews G, Ozkaynak H and Neas LM: GIS-modeled indicators of traffic-related air pollutants and adverse pulmonary health among children in El Paso, Texas. Am J Epidemiol. 176 (Suppl 7):S131–S141. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Khoury MJ, Iademarco MF and Riley WT: Precision Public Health for the Era of Precision Medicine. Am J Prev Med. 50:398–401. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Tao P, Zheng W, Wang Y and Bian ML: Sensitive HPV genotyping based on the flow-through hybridization and gene chip. J Biomed Biotechnol. 2012:9387802012. View Article : Google Scholar : PubMed/NCBI

16 

Zou H, Meng X, Jia T, Zhu C, Chen X, Li X, Xu J, Ma W and Zhang X: Awareness and acceptance of human papillomavirus (HPV) vaccination among males attending a major sexual health clinic in Wuxi, China: A cross-sectional study. Hum Vaccin Immunother. 12:1551–1559. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Adenis A, Dufit V, Douine M, Corlin F, Ayhan G, Najioullah F, Molinie V, Brousse P, Carles G, Lacoste V, et al: High prevalence of HPV infection in the remote villages of French Guiana: An epidemiological study. Epidemiol Infect. 145:1276–1284. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Lynge E, Clausen LB, Guignard R and Poll P: What happens when organization of cervical cancer screening is delayed or stopped. J Med Screen. 13:41–46. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Sankaranarayanan R, Nene BM, Shastri SS, Jayant K, Muwonge R, Budukh AM, Hingmire S, Malvi SG, Thorat R, Kothari A, et al: HPV screening for cervical cancer in rural India. N Engl J Med. 360:1385–1394. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Sukvirach S, Smith JS, Tunsakul S, Muñoz N, Kesararat V, Opasatian O, Chichareon S, Kaenploy V, Ashley R, Meijer CJ, et al: Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand. J Infect Dis. 187:1246–1256. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Li N, Hang D, Yang L, Feng X, Lyu Z, Xie S, Zhou J, Wu L, Li X, Li N, et al: Persistence of type-specific human papillomavirus infection among Daqing City women in China with normal cytology: A pilot prospective study. Oncotarget. 8:81455–81461. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Mammas IN, Spandidos DA and Sourvinos G: Genomic diversity of human papillomaviruses (HPV) and clinical implications: An overview in adulthood and childhood. Infect. Genet Evol. 21:220–226. 2014. View Article : Google Scholar

23 

Nygård M, Hansen BT, Dillner J, Munk C, Oddsson K, Tryggvadottir L, Hortlund M, Liaw KL, Dasbach EJ and Kjær SK: Targeting human papillomavirus to reduce the burden of cervical, vulvar and vaginal cancer and pre-invasive neoplasia: Establishing the baseline for surveillance. PLoS One. 9:e883232014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xing J, Tan T, Guo Y, Zhu J, Zheng A, Yu A and Niu Z: Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China. Oncol Lett 21: 366, 2021.
APA
Xing, J., Tan, T., Guo, Y., Zhu, J., Zheng, A., Yu, A., & Niu, Z. (2021). Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China. Oncology Letters, 21, 366. https://doi.org/10.3892/ol.2021.12627
MLA
Xing, J., Tan, T., Guo, Y., Zhu, J., Zheng, A., Yu, A., Niu, Z."Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China". Oncology Letters 21.5 (2021): 366.
Chicago
Xing, J., Tan, T., Guo, Y., Zhu, J., Zheng, A., Yu, A., Niu, Z."Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China". Oncology Letters 21, no. 5 (2021): 366. https://doi.org/10.3892/ol.2021.12627
Copy and paste a formatted citation
x
Spandidos Publications style
Xing J, Tan T, Guo Y, Zhu J, Zheng A, Yu A and Niu Z: Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China. Oncol Lett 21: 366, 2021.
APA
Xing, J., Tan, T., Guo, Y., Zhu, J., Zheng, A., Yu, A., & Niu, Z. (2021). Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China. Oncology Letters, 21, 366. https://doi.org/10.3892/ol.2021.12627
MLA
Xing, J., Tan, T., Guo, Y., Zhu, J., Zheng, A., Yu, A., Niu, Z."Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China". Oncology Letters 21.5 (2021): 366.
Chicago
Xing, J., Tan, T., Guo, Y., Zhu, J., Zheng, A., Yu, A., Niu, Z."Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China". Oncology Letters 21, no. 5 (2021): 366. https://doi.org/10.3892/ol.2021.12627
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