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Review

Comparative investigation of early‑onset gastric cancer (Review)

  • Authors:
    • Zhen Ma
    • Xiaolong Liu
    • Maswikiti Ewetse Paul
    • Mali  Chen
    • Peng Zheng
    • Hao Chen
  • View Affiliations / Copyright

    Affiliations: The Second Clinical Medical College, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu 730030, P.R. China, Department of Labor, Delivery and Recovery, Gansu Provincial Maternity and Childcare Hospital, Lanzhou, Gansu 730030, P.R. China
  • Article Number: 374
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    Published online on: March 13, 2021
       https://doi.org/10.3892/ol.2021.12635
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Abstract

Early‑onset gastric cancer (EOGC) is a serious social burden. For patients with EOGC, typically considered as those aged <45 years, the underlying cause of the disease remains unclear. In addition, several misunderstandings of EOGC remain in clinical practice. Upon diagnosis, numerous patients with EOGC are already at an advanced stage (stage IV) of the disease and are unable to benefit from treatment. Moreover, several conclusions and data obtained from different EOGC studies appear to be to contradictory. The literature indicates that the incidence of EOGC is gradually rising, and that EOGC differs from traditional and familial gastric cancer in terms of clinicopathological characteristics. Patients with EOGC typically exhibit low survival rates, poor prognosis, rapid disease progression, a low degree of differentiation (signet‑ring cell tumors are common) and rapid lymph node and distant metastasis, among other characteristics. The molecular genetic mechanisms of EOGC are also significantly different from those of traditional gastric cancer. An improved definition of EOCG may provide a reference for clinical diagnosis and treatment, and clear guidelines may serve as a basis for more accurate diagnosis and the development of effective treatment strategies.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Feng RM, Zong YN, Cao SM and Xu RH: Current cancer situation in China: Good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond). 39:222019. View Article : Google Scholar : PubMed/NCBI

3 

Takatsu Y, Hiki N, Nunobe S, Ohashi M, Honda M, Yamaguchi T, Nakajima T and Sano T: Clinicopathological features of gastric cancer in young patients. Gastric Cancer. 19:472–478. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Bacani J, Zwingerman R, Di Nicola N, Spencer S, Wegrynowski T, Mitchell K, Hay K, Redston M, Holowaty E, Huntsman D, et al: Tumor microsatellite instability in early onset gastric cancer. J Mol Diagn. 7:465–477. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Strong VE, Russo A, Yoon SS, Brennan MF, Coit DG, Zheng CH, Li P and Huang CM: Comparison of young patients with gastric cancer in the United States and China. Ann Surg Oncol. 24:3964–3971. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Mun DG, Bhin J, Kim S, Kim H, Jung JH, Jung Y, Jang YE, Park JM, Kim H, Jung Y, et al: Proteogenomic characterization of human early-onset gastric cancer. Cancer Cell. 35:111–124.e10. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Medina-Franco H, Heslin MJ and Cortes-Gonzalez R: Clinicopathological characteristics of gastric carcinoma in young and elderly patients: A comparative study. Ann Surg Oncol. 7:515–519. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Bergquist JR, Leiting JL, Habermann EB, Cleary SP, Kendrick ML, Smoot RL, Nagorney DM, Truty MJ and Grotz TE: Early-onset gastric cancer is a distinct disease with worrisome trends and oncogenic features. Surgery. 166:547–555. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Merchant SJ, Kim J, Choi AH, Sun V, Chao J and Nelson R: A rising trend in the incidence of advanced gastric cancer in young Hispanic men. Gastric Cancer. 20:226–234. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Al-Refaie WB, Hu CY, Pisters PW and Chang GJ: Gastric adenocarcinoma in young patients: A population-based appraisal. Ann Surg Oncol. 18:2800–2807. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Carvalho R, Milne AN, van Rees BP, Caspers E, Cirnes L, Figueiredo C, Offerhaus GJ and Weterman MA: Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age. J Pathol. 204:75–83. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Kim DY, Ryu SY, Kim YJ and Kim SK: Clinicopathological characteristics of gastric carcinoma in young patients. Langenbecks Arch Surg. 388:245–249. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Helicobacter and Cancer Collaborative Group, . Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 49:347–353. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Infection with Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum. 61:177–240. 1994.PubMed/NCBI

15 

Crowe SE: Helicobacter pylori Infection. N Engl J Med. 380:1158–1165. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Li WQ, Ma JL, Zhang L, Brown LM, Li JY, Shen L, Pan KF, Liu WD, Hu Y, Han ZX, et al: Effects of Helicobacter pylori treatment on gastric cancer incidence and mortality in subgroups. J Natl Cancer Inst. 106:dju1162014. View Article : Google Scholar : PubMed/NCBI

17 

Ma JL, Zhang L, Brown LM, Li JY, Shen L, Pan KF, Liu WD, Hu Y, Han ZX, Crystal-Mansour S, et al: Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 104:488–492. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Giryes A, Oweira H, Mannhart M, Decker M and Abdel-Rahman O: Exploring the differences between early-onset gastric cancer and traditional-onset gastric cancer. J Gastrointest Oncol. 9:1157–1163. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Correa P and Shiao YH: Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res. 54 (7 Suppl):1941s–1943s. 1994.PubMed/NCBI

20 

Kokkola A and Sipponen P: Gastric carcinoma in young adults. Hepatogastroenterology. 48:1552–1555. 2001.PubMed/NCBI

21 

Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49. 1965. View Article : Google Scholar : PubMed/NCBI

22 

Correa P: Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol. 19 (Suppl 1):S37–S43. 1995.PubMed/NCBI

23 

Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Miwa S, Tsuneyama K and Takano Y: Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: An immunostaining study on the tissue microarray. J Clin Pathol. 60:273–277. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Han MA, Oh MG, Choi IJ, Park SR, Ryu KW, Nam BH, Cho SJ, Kim CG, Lee JH and Kim YW: Association of family history with cancer recurrence and survival in patients with gastric cancer. J Clin Oncol. 30:701–708. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al: Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet. 8:e10026292012. View Article : Google Scholar : PubMed/NCBI

26 

Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, et al: Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res. 20:440–446. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Cheng AS, Li MS, Kang W, Cheng VY, Chou JL, Lau SS, Go MY, Lee CC, Ling TK, Ng EK, et al: Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology. 144:122–133.e9. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, Hui WM, Rashid A and Kwong YL: Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. 52:502–506. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Cui Y, Gao D, Linghu E, Zhan Q, Chen R, Brock MV, Herman JG and Guo M: Epigenetic changes and functional study of HOXA11 in human gastric cancer. Epigenomics. 7:201–213. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Ge Y, Wu Q, Ma G, Shao W, Liu H, Zhang Q, Xin J, Xue Y, Du M, Zhao Q, et al: Hypermethylation of EIF4E promoter is associated with early onset of gastric cancer. Carcinogenesis. 39:66–71. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM and Roa JC: The gene expression status of the PI3K/AKT/mTOR pathway in gastric cancer tissues and cell lines. Pathol Oncol Res. 22:797–805. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Theuer CP, de Virgilio C, Keese G, French S, Arnell T, Tolmos J, Klein S, Powers W, Oh T and Stabile BE: Gastric adenocarcinoma in patients 40 years of age or younger. Am J Surg. 172:473–477. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Smith BR and Stabile BE: Extreme aggressiveness and lethality of gastric adenocarcinoma in the very young. Arch Surg. 144:506–510. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Theuer CP, Kurosaki T, Taylor TH and Anton-Culver H: Unique features of gastric carcinoma in the young: A population-based analysis. Cancer. 83:25–33. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Hsieh FJ, Wang YC, Hsu JT, Liu KH and Yeh CN: Clinicopathological features and prognostic factors of gastric cancer patients aged 40 years or younger. J Surg Oncol. 105:304–309. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Saito H, Takaya S, Fukumoto Y, Osaki T, Tatebe S and Ikeguchi M: Clinicopathologic characteristics and prognosis of gastric cancer in young patients. Yonago Acta Med. 55:57–61. 2012.PubMed/NCBI

37 

Santoro R, Carboni F, Lepiane P, Ettorre GM and Santoro E: Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg. 94:737–742. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Kunisaki C, Akiyama H, Nomura M, Matsuda G, Otsuka Y, Ono HA, Takagawa R, Nagahori Y, Takahashi M, Kito F and Shimada H: Clinicopathological features of gastric carcinoma in younger and middle-aged patients: A comparative study. J Gastrointest Surg. 10:1023–1032. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Rona KA, Schwameis K, Zehetner J, Samakar K, Green K, Samaan J, Sandhu K, Bildzukewicz N, Katkhouda N and Lipham JC: Gastric cancer in the young: An advanced disease with poor prognostic features. J Surg Oncol. 115:371–375. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Isobe T, Hashimoto K, Kizaki J, Miyagi M, Aoyagi K, Koufuji K and Shirouzu K: Characteristics and prognosis of gastric cancer in young patients. Oncol Rep. 30:43–49. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Bautista MC, Jiang SF, Armstrong MA, Postlethwaite D and Li D: Impact of age on clinicopathological features and survival of patients with noncardia gastric adenocarcinoma. J Gastric Cancer. 14:238–245. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Furukawa H, Iwanaga T, Imaoka S, Hiratsuka M, Fukuda I, Kabuto T, Ishikawa O and Sasaki Y: Multifocal gastric cancer in patients younger than 50 years of age. Eur Surg Res. 21:313–318. 1989. View Article : Google Scholar : PubMed/NCBI

43 

Lim S, Lee HS, Kim HS, Kim YI and Kim WH: Alteration of E-cadherin-mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers. Histopathology. 42:128–136. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Matley PJ, Dent DM, Madden MV and Price SK: Gastric carcinoma in young adults. Ann Surg. 208:593–596. 1988. View Article : Google Scholar : PubMed/NCBI

45 

Maeta M, Yamashiro H, Oka A, Tsujitani S, Ikeguchi M and Kaibara N: Gastric cancer in the young, with special reference to 14 pregnancy-associated cases: Analysis based on 2,325 consecutive cases of gastric cancer. J Surg Oncol. 58:191–195. 1995. View Article : Google Scholar : PubMed/NCBI

46 

Milne AN, Sitarz R, Carvalho R, Carneiro F and Offerhaus GJ: Early onset gastric cancer: On the road to unraveling gastric carcinogenesis. Curr Mol Med. 7:15–28. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Karim S: Clinicopathological and p53 gene alteration comparison between young and older patients with gastric cancer. Asian Pac J Cancer Prev. 15:1375–1379. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Milne AN, Carvalho R, Morsink FM, Musler AR, de Leng WW, Ristimäki A and Offerhaus GJ: Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. Mod Pathol. 19:564–572. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Buffart TE, Carvalho B, Hopmans E, Brehm V, Kranenbarg EK, Schaaij-Visser TB, Eijk PP, van Grieken NC, Ylstra B, van de Velde CJ and Meijer GA: Gastric cancers in young and elderly patients show different genomic profiles. J Pathol. 211:45–51. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Chung HW, Noh SH and Lim JB: Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea. World J Gastroenterol. 16:256–263. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, et al: Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 45:371–384e1-2. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, et al: A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet. 43:1215–1218. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, et al: A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet. 42:764–767. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, et al: Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 43:679–684. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, et al: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet. 42:759–763. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Cui R, Kamatani Y, Takahashi A, Usami M, Hosono N, Kawaguchi T, Tsunoda T, Kamatani N, Kubo M, Nakamura Y and Matsuda K: Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology. 137:1768–1775. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Du J, Xu Y, Dai J, Ren C, Zhu C, Dai N, Ma H, Shi Y, Hu Z, Lin D, et al: Genetic variants at 5p15 are associated with risk and early onset of gastric cancer in Chinese populations. Carcinogenesis. 34:2539–2542. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Gravalos C and Jimeno A: HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target. Ann Oncol. 19:1523–1529. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Tanner M, Hollmén M, Junttila TT, Kapanen AI, Tommola S, Soini Y, Helin H, Salo J, Joensuu H, Sihvo E, et al: Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol. 16:273–278. 2005. View Article : Google Scholar : PubMed/NCBI

60 

Yan B, Yau EX, Bte Omar SS, Ong CW, Pang B, Yeoh KG and Salto-Tellez M: A study of HER2 gene amplification and protein expression in gastric cancer. J Clin Pathol. 63:839–842. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Moelans CB, Milne AN, Morsink FH, Offerhaus GJ and van Diest PJ: Low frequency of HER2 amplification and overexpression in early onset gastric cancer. Cell Oncol (Dordr). 34:89–95. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Venerito M, Vasapolli R, Rokkas T and Malfertheiner P: Gastric cancer: Epidemiology, prevention, and therapy. Helicobacter. 23 (Suppl 1):e125182018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma Z, Liu X, Paul ME, Chen M, Zheng P and Chen H: Comparative investigation of early‑onset gastric cancer (Review). Oncol Lett 21: 374, 2021.
APA
Ma, Z., Liu, X., Paul, M.E., Chen, M., Zheng, P., & Chen, H. (2021). Comparative investigation of early‑onset gastric cancer (Review). Oncology Letters, 21, 374. https://doi.org/10.3892/ol.2021.12635
MLA
Ma, Z., Liu, X., Paul, M. E., Chen, M., Zheng, P., Chen, H."Comparative investigation of early‑onset gastric cancer (Review)". Oncology Letters 21.5 (2021): 374.
Chicago
Ma, Z., Liu, X., Paul, M. E., Chen, M., Zheng, P., Chen, H."Comparative investigation of early‑onset gastric cancer (Review)". Oncology Letters 21, no. 5 (2021): 374. https://doi.org/10.3892/ol.2021.12635
Copy and paste a formatted citation
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Spandidos Publications style
Ma Z, Liu X, Paul ME, Chen M, Zheng P and Chen H: Comparative investigation of early‑onset gastric cancer (Review). Oncol Lett 21: 374, 2021.
APA
Ma, Z., Liu, X., Paul, M.E., Chen, M., Zheng, P., & Chen, H. (2021). Comparative investigation of early‑onset gastric cancer (Review). Oncology Letters, 21, 374. https://doi.org/10.3892/ol.2021.12635
MLA
Ma, Z., Liu, X., Paul, M. E., Chen, M., Zheng, P., Chen, H."Comparative investigation of early‑onset gastric cancer (Review)". Oncology Letters 21.5 (2021): 374.
Chicago
Ma, Z., Liu, X., Paul, M. E., Chen, M., Zheng, P., Chen, H."Comparative investigation of early‑onset gastric cancer (Review)". Oncology Letters 21, no. 5 (2021): 374. https://doi.org/10.3892/ol.2021.12635
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