Comparative investigation of early‑onset gastric cancer (Review)

  • Authors:
    • Zhen Ma
    • Xiaolong Liu
    • Maswikiti Ewetse Paul
    • Mali  Chen
    • Peng Zheng
    • Hao Chen
  • View Affiliations

  • Published online on: March 13, 2021     https://doi.org/10.3892/ol.2021.12635
  • Article Number: 374
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Abstract

Early‑onset gastric cancer (EOGC) is a serious social burden. For patients with EOGC, typically considered as those aged <45 years, the underlying cause of the disease remains unclear. In addition, several misunderstandings of EOGC remain in clinical practice. Upon diagnosis, numerous patients with EOGC are already at an advanced stage (stage IV) of the disease and are unable to benefit from treatment. Moreover, several conclusions and data obtained from different EOGC studies appear to be to contradictory. The literature indicates that the incidence of EOGC is gradually rising, and that EOGC differs from traditional and familial gastric cancer in terms of clinicopathological characteristics. Patients with EOGC typically exhibit low survival rates, poor prognosis, rapid disease progression, a low degree of differentiation (signet‑ring cell tumors are common) and rapid lymph node and distant metastasis, among other characteristics. The molecular genetic mechanisms of EOGC are also significantly different from those of traditional gastric cancer. An improved definition of EOCG may provide a reference for clinical diagnosis and treatment, and clear guidelines may serve as a basis for more accurate diagnosis and the development of effective treatment strategies.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ma Z, Liu X, Paul ME, Chen M, Zheng P and Chen H: Comparative investigation of early‑onset gastric cancer (Review). Oncol Lett 21: 374, 2021
APA
Ma, Z., Liu, X., Paul, M.E., Chen, M., Zheng, P., & Chen, H. (2021). Comparative investigation of early‑onset gastric cancer (Review). Oncology Letters, 21, 374. https://doi.org/10.3892/ol.2021.12635
MLA
Ma, Z., Liu, X., Paul, M. E., Chen, M., Zheng, P., Chen, H."Comparative investigation of early‑onset gastric cancer (Review)". Oncology Letters 21.5 (2021): 374.
Chicago
Ma, Z., Liu, X., Paul, M. E., Chen, M., Zheng, P., Chen, H."Comparative investigation of early‑onset gastric cancer (Review)". Oncology Letters 21, no. 5 (2021): 374. https://doi.org/10.3892/ol.2021.12635