Open Access

Role of FAT1 in health and disease (Review)

  • Authors:
    • Zizhen Peng
    • Yanyu Gong
    • Xiaoqiu Liang
  • View Affiliations

  • Published online on: March 18, 2021     https://doi.org/10.3892/ol.2021.12659
  • Article Number: 398
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

FAT atypical cadherin 1 (FAT1), which encodes a protocadherin, is one of the most frequently mutated genes in human cancer. Over the past 20 years, the role of FAT1 in tissue growth and in the development of diseases has been extensively studied. There is definitive evidence that FAT1 serves a substantial role in the maintenance of organs and development, and its expression appears to be tissue‑specific. FAT1 activates a variety of signaling pathways through protein‑protein interactions, including the Wnt/β‑catenin, Hippo and MAPK/ERK signaling pathways, which affect cell proliferation, migration and invasion. Abnormal FAT1 expression may lead to the development of tumors and may affect prognosis. Therefore, FAT1 may have potential in tumor therapy. The structural and functional changes mediated by FAT1, its tissue distribution and changes in FAT1 expression in human diseases are described in the present review, which provides further insight for understanding the role of FAT1 in development and disease.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Peng Z, Gong Y and Liang X: Role of FAT1 in health and disease (Review). Oncol Lett 21: 398, 2021
APA
Peng, Z., Gong, Y., & Liang, X. (2021). Role of FAT1 in health and disease (Review). Oncology Letters, 21, 398. https://doi.org/10.3892/ol.2021.12659
MLA
Peng, Z., Gong, Y., Liang, X."Role of FAT1 in health and disease (Review)". Oncology Letters 21.5 (2021): 398.
Chicago
Peng, Z., Gong, Y., Liang, X."Role of FAT1 in health and disease (Review)". Oncology Letters 21, no. 5 (2021): 398. https://doi.org/10.3892/ol.2021.12659