Open Access

Possibility of inducing tumor cell senescence during therapy (Review)

  • Authors:
    • Guohui Wang
    • Xianliang Cheng
    • Jingyi Zhang
    • Yuan Liao
    • Yinnong Jia
    • Chen Qing
  • View Affiliations

  • Published online on: April 27, 2021     https://doi.org/10.3892/ol.2021.12757
  • Article Number: 496
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The treatment options for cancer include surgery, radiotherapy and chemotherapy. However, the traditional approach of high‑dose chemotherapy brings tremendous toxic side effects to patients, as well as potentially causing drug resistance. Drug resistance affects cell proliferation, cell senescence and apoptosis. Cellular senescence refers to the process in which cells change from an active proliferative status to a growth‑arrested status. There are multiple factors that regulate this process and cellular senescence is activated by various pathways. Senescent cells present specific characteristics, such as an increased cell volume, flattened cell body morphology, ceased cell division and the expression of β‑galactosidase. Tumor senescence can be categorized into replicative senescence and premature senescence. Cellular senescence may inhibit the occurrence and development of tumors, serving as an innovative strategy for the treatment of cancer. The present review mainly focuses on senescent biomarkers, methods for the induction of cellular senescence and its possible application in the treatment of cancer.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang G, Cheng X, Zhang J, Liao Y, Jia Y and Qing C: Possibility of inducing tumor cell senescence during therapy (Review). Oncol Lett 22: 496, 2021.
APA
Wang, G., Cheng, X., Zhang, J., Liao, Y., Jia, Y., & Qing, C. (2021). Possibility of inducing tumor cell senescence during therapy (Review). Oncology Letters, 22, 496. https://doi.org/10.3892/ol.2021.12757
MLA
Wang, G., Cheng, X., Zhang, J., Liao, Y., Jia, Y., Qing, C."Possibility of inducing tumor cell senescence during therapy (Review)". Oncology Letters 22.1 (2021): 496.
Chicago
Wang, G., Cheng, X., Zhang, J., Liao, Y., Jia, Y., Qing, C."Possibility of inducing tumor cell senescence during therapy (Review)". Oncology Letters 22, no. 1 (2021): 496. https://doi.org/10.3892/ol.2021.12757