Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)

  • Authors:
    • Zhengjun Zhou
    • Junjie Tian
    • Wenyan Zhang
    • Wei Xiang
    • Yang Ming
    • Ligang Chen
    • Jie Zhou
  • View Affiliations

  • Published online on: May 3, 2021     https://doi.org/10.3892/ol.2021.12771
  • Article Number: 510
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Abstract

Oncolytic viruses have attracted widespread attention as biological anticancer agents that can selectively kill tumor cells without affecting normal cells. Although progress has been made in therapeutic strategies, the prognosis of patients with glioblastoma (GBM) remains poor and no ideal treatment approach has been developed. Recently, oncolytic herpes simplex virus (oHSV) has been considered a promising novel treatment approach for GBM. However, the therapeutic efficacy of oHSV in GBM, with its intricate pathophysiology, remains unsatisfactory due to several obstacles, such as limited replication and attenuated potency of oHSV owing to deletions or mutations in virulence genes, and ineffective delivery of the therapeutic virus. Multiple strategies have attempted to identify the optimal strategy for the successful clinical application of oHSV. Several preclinical trials have demonstrated that engineering novel oHSVs, developing combination therapies and improving methods for delivering oHSV to tumor cells seem to hold promise for improving the efficacy of this virotherapy.

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July-2021
Volume 22 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Z, Tian J, Zhang W, Xiang W, Ming Y, Chen L and Zhou J: Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review). Oncol Lett 22: 510, 2021
APA
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., & Zhou, J. (2021). Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review). Oncology Letters, 22, 510. https://doi.org/10.3892/ol.2021.12771
MLA
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., Zhou, J."Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)". Oncology Letters 22.1 (2021): 510.
Chicago
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., Zhou, J."Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)". Oncology Letters 22, no. 1 (2021): 510. https://doi.org/10.3892/ol.2021.12771