Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2021 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)

  • Authors:
    • Zhengjun Zhou
    • Junjie Tian
    • Wenyan Zhang
    • Wei Xiang
    • Yang Ming
    • Ligang Chen
    • Jie Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
  • Article Number: 510
    |
    Published online on: May 3, 2021
       https://doi.org/10.3892/ol.2021.12771
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oncolytic viruses have attracted widespread attention as biological anticancer agents that can selectively kill tumor cells without affecting normal cells. Although progress has been made in therapeutic strategies, the prognosis of patients with glioblastoma (GBM) remains poor and no ideal treatment approach has been developed. Recently, oncolytic herpes simplex virus (oHSV) has been considered a promising novel treatment approach for GBM. However, the therapeutic efficacy of oHSV in GBM, with its intricate pathophysiology, remains unsatisfactory due to several obstacles, such as limited replication and attenuated potency of oHSV owing to deletions or mutations in virulence genes, and ineffective delivery of the therapeutic virus. Multiple strategies have attempted to identify the optimal strategy for the successful clinical application of oHSV. Several preclinical trials have demonstrated that engineering novel oHSVs, developing combination therapies and improving methods for delivering oHSV to tumor cells seem to hold promise for improving the efficacy of this virotherapy.
View Figures

Figure 1

View References

1 

Kang X, Zheng Y, Hong W, Chen X, Li H, Huang B, Huang Z, Tang H and Geng W: Recent advances in immune cell therapy for glioblastoma. Front Immunol. 11:5445632020. View Article : Google Scholar : PubMed/NCBI

2 

Upadhaya PG, Pulakkat S and Patravale VB: Nose-to-brain delivery: Exploring newer domains for glioblastoma multiforme management. Drug Deliv Transl Res. 10:1044–1056. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Alexander BM and Cloughesy TF: Adult glioblastoma. J Clin Oncol. 35:2402–2409. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Ebrahimi S, Makvandi M, Abbasi S, Azadmanesh K and Teimoori A: Developing oncolytic Herpes simplex virus type 1 through UL39 knockout by CRISPR-Cas9. Iran J Basic Med Sci. 23:937–944. 2020.PubMed/NCBI

5 

Taylor TJ, Brockman MA, McNamee EE and Knipe DM: Herpes simplex virus. Front Biosci. 7:d752–764. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Watanabe D and Goshima F: Oncolytic virotherapy by HSV. Adv Exp Med Biol. 1045:63–84. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Goldstein DJ and Weller SK: Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: Characterization of an ICP6 deletion mutant. Virology. 166:41–51. 1988. View Article : Google Scholar : PubMed/NCBI

8 

Wilcox DR and Longnecker R: The herpes simplex virus neurovirulence factor γ34.5: Revealing Virus-host interactions. PLoS Pathog. 12:e10054492016. View Article : Google Scholar : PubMed/NCBI

9 

Varghese S and Rabkin SD: Oncolytic herpes simplex virus vectors for cancer virotherapy. Cancer Gene Ther. 9:967–978. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Glorioso JC, Cohen JB, Goins WF, Hall B, Jackson JW, Kohanbash G, Amankulor N, Kaur B, Caligiuri MA, Chiocca EA, et al: Oncolytic HSV vectors and anti-tumor immunity. Curr Issues Mol Biol. 41:381–468. 2020.PubMed/NCBI

11 

Martuza RL, Malick A, Markert JM, Ruffner KL and Coen DM: Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science. 252:854–856. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Peters C, Paget M, Tshilenge KT, Saha D, Antoszczyk S, Baars A, Frost T, Martuza RL, Wakimoto H and Rabkin SD: Restriction of replication of oncolytic herpes simplex virus with a deletion of γ34.5 in glioblastoma stem-like cells. J Virol. 92:e00246–18. 2018. View Article : Google Scholar

13 

Mineta T, Rabkin SD, Yazaki T, Hunter WD and Martuza RL: Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nat Med. 1:938–943. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Kanai R, Zaupa C, Sgubin D, Antoszczyk SJ, Martuza RL, Wakimoto H and Rabkin SD: Effect of gamma34.5 deletions on oncolytic herpes simplex virus activity in brain tumors. J Virol. 86:4420–4431. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Kambara H, Okano H, Chiocca EA and Saeki Y: An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res. 65:2832–2839. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Connor JH, Weiser DC, Li S, Hallenbeck JM and Shenolikar S: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol. 21:6841–6850. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Nakashima H, Nguyen T, Kasai K, Passaro C, Ito H, Goins WF, Shaikh I, Erdelyi R, Nishihara R, Nakano I, et al: Toxicity and efficacy of a novel GADD34-expressing oncolytic HSV-1 for the treatment of experimental glioblastoma. Clin Cancer Res. 24:2574–2584. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Friedman GK, Nan L, Haas MC, Kelly VM, Moore BP, Langford CP, Xu H, Han X, Beierle EA, Markert JM, et al: γ134.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia. Gene Ther. 22:348–355. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Cassady KA: Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection. J Virol. 79:8707–8715. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Cassady KA, Bauer DF, Roth J, Chambers MR, Shoeb T, Coleman J, Prichard M, Gillespie GY and Markert JM: Pre-clinical assessment of C134, a chimeric oncolytic herpes simplex virus, in mice and non-human primates. Mol Ther Oncolytics. 5:1–10. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Campadelli-Fiume G, Petrovic B, Leoni V, Gianni T, Avitabile E, Casiraghi C and Gatta V: Retargeting strategies for oncolytic herpes simplex viruses. Viruses. 8:632016. View Article : Google Scholar : PubMed/NCBI

22 

Campadelli-Fiume G, Menotti L, Avitabile E and Gianni T: Viral and cellular contributions to herpes simplex virus entry into the cell. Curr Opin Virol. 2:28–36. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Zhang C, Burger MC, Jennewein L, Genssler S, Schönfeld K, Zeiner P, Hattingen E, Harter PN, Mittelbronn M, Tonn T, et al: ErbB2/HER2-specific NK cells for targeted therapy of glioblastoma. J Natl Cancer Inst. Dec 6–2016.(Epub ahead of print). doi: 10.1093/jnci/djv375. View Article : Google Scholar

24 

Menotti L, Cerretani A, Hengel H and Campadelli-Fiume G: Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2. J Virol. 82:10153–10161. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Gambini E, Reisoli E, Appolloni I, Gatta V, Campadelli-Fiume G, Menotti L and Malatesta P: Replication-competent herpes simplex virus retargeted to HER2 as therapy for high-grade glioma. Mol Ther. 20:994–1001. 2012. View Article : Google Scholar : PubMed/NCBI

26 

An Z, Aksoy O, Zheng T, Fan QW and Weiss WA: Epidermal growth factor receptor and EGFRvIII in glioblastoma: Signaling pathways and targeted therapies. Oncogene. 37:1561–1575. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CS, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, et al: Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus. Mol Ther. 21:561–569. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Mazzacurati L, Marzulli M, Reinhart B, Miyagawa Y, Uchida H, Goins WF, Li A, Kaur B, Caligiuri M, Cripe T, et al: Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV. Mol Ther. 23:99–107. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Chen Q, Han B, Meng X, Duan C, Yang C, Wu Z, Magafurov D, Zhao S, Safin S, Jiang C and Cai J: Immunogenomic analysis reveals LGALS1 contributes to the immune heterogeneity and immunosuppression in glioma. Int J Cancer. 145:517–530. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Zhang Q and Liu F: Advances and potential pitfalls of oncolytic viruses expressing immunomodulatory transgene therapy for malignant gliomas. Cell Death Dis. 11:4852020. View Article : Google Scholar : PubMed/NCBI

31 

Kim CY, Jeong M, Mushiake H, Kim BM, Kim WB, Ko JP, Kim MH, Kim M, Kim TH, Robbins PD, et al: Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Therapy. 13:330–338. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Passaro C, Alayo Q, De Laura I, McNulty J, Grauwet K, Ito H, Bhaskaran V, Mineo M, Lawler SE, Shah K, et al: Arming an oncolytic herpes simplex virus type 1 with a Single-chain fragment variable antibody against PD-1 for experimental glioblastoma therapy. Clin Cancer Res. 25:290–299. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Wirsching HG, Zhang H, Szulzewsky F, Arora S, Grandi P, Cimino PJ, Amankulor N, Campbell JS, McFerrin L, Pattwell SS, et al: Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma. JCI insight. 4:e1282172019. View Article : Google Scholar : PubMed/NCBI

34 

Xu B, Ma R, Russell L, Yoo JY, Han J, Cui H, Yi P, Zhang J, Nakashima H, Dai H, et al: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. Nov 26–2018.(Epub ahead of print). doi: 10.1038/nbt.4302.

35 

Zhu G, Su W, Jin G, Xu F, Hao S, Guan F, Jia W and Liu F: Glioma stem cells targeted by oncolytic virus carrying endostatin-angiostatin fusion gene and the expression of its exogenous gene in vitro. Brain Res. 1390:59–69. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Kucerova L, Durinikova E, Toro L, Cihova M, Miklikova S, Poturnajova M, Kozovska Z and Matuskova M: Targeted antitumor therapy mediated by prodrug-activating mesenchymal stromal cells. Cancer Lett. 408:1–9. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Nakamura H, Mullen JT, Chandrasekhar S, Pawlik TM, Yoon SS and Tanabe KK: Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil. Cancer Res. 61:5447–5452. 2001.PubMed/NCBI

38 

Yamada S, Kuroda T, Fuchs BC, He X, Supko JG, Schmitt A, McGinn CM, Lanuti M and Tanabe KK: Oncolytic herpes simplex virus expressing yeast cytosine deaminase: Relationship between viral replication, transgene expression, prodrug bioactivation. Cancer Gene Ther. 19:160–170. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Sattiraju A, Sai KKS and Mintz A: Glioblastoma stem cells and their microenvironment. Adv Exp Med Biol. 1041:119–140. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Kanai R, Rabkin SD, Yip S, Sgubin D, Zaupa CM, Hirose Y, Louis DN, Wakimoto H and Martuza RL: Oncolytic virus-mediated manipulation of DNA damage responses: Synergy with chemotherapy in killing glioblastoma stem cells. J Natl Cancer Inst. 104:42–55. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Aghi M, Rabkin S and Martuza RL: Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. J Natl Cancer Inst. 98:38–50. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Wade A, Robinson AE, Engler JR, Petritsch C, James CD and Phillips JJ: Proteoglycans and their roles in brain cancer. FEBS J. 280:2399–2417. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Dmitrieva N, Yu L, Viapiano M, Cripe TP, Chiocca EA, Glorioso JC and Kaur B: Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 17:1362–1372. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Jaime-Ramirez AC, Dmitrieva N, Yoo JY, Banasavadi-Siddegowda Y, Zhang J, Relation T, Bolyard C, Wojton J and Kaur B: Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide. J Gene Med. 19:10.1002/jgm.2942. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Saha D, Rabkin SD and Martuza RL: Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma. J Immunother Cancer. 8:e0003452020. View Article : Google Scholar : PubMed/NCBI

46 

Advani SJ, Mezhir JJ, Roizman B and Weichselbaum RR: ReVOLT: Radiation-enhanced viral oncolytic therapy. Int J Radiat Oncol Biol Phys. 66:637–646. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Kanai R, Wakimoto H, Martuza RL and Rabkin SD: A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells. Clin Cancer Res. 17:3686–3696. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Cheema TA, Kanai R, Kim GW, Wakimoto H, Passer B, Rabkin SD and Martuza RL: Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts. Clin Cancer Res. 17:7383–7393. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Zhang W, Fulci G, Wakimoto H, Cheema TA, Buhrman JS, Jeyaretna DS, Stemmer Rachamimov AO, Rabkin SD and Martuza RL: Combination of oncolytic herpes simplex viruses armed with angiostatin and IL-12 enhances antitumor efficacy in human glioblastoma models. Neoplasia. 15:591–599. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg FH, Weissleder R, Carson W, Chiocca EA and Kaur B: Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. J Natl Cancer Inst. 99:1768–1781. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD and Martuza RL: Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Mol Ther. 20:37–45. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Yoo JY, Jaime-Ramirez AC, Bolyard C, Dai H, Nallanagulagari T, Wojton J, Hurwitz BS, Relation T, Lee TJ, Lotze MT, et al: Bortezomib treatment sensitizes oncolytic HSV-1-treated tumors to NK cell immunotherapy. Clin Cancer Res. 22:5265–5276. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Yoo JY, Hurwitz BS, Bolyard C, Yu JG, Zhang J, Selvendiran K, Rath KS, He S, Bailey Z, Eaves D, et al: Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects. Clin Cancer Res. 20:3787–3798. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Ning J, Wakimoto H, Peters C, Martuza RL and Rabkin SD: Rad51 degradation: Role in oncolytic Virus-Poly(ADP-Ribose) polymerase inhibitor combination therapy in glioblastoma. J Natl Cancer Inst. 109:1–13. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Carbonell WS, DeLay M, Jahangiri A, Park CC and Aghi MK: β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma. Cancer Res. 73:3145–3154. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Lee TJ, Nair M, Banasavadi-Siddegowda Y, Liu J, Nallanagulagari T, Jaime-Ramirez AC, Guo JY, Quadri H, Zhang J, Bockhorst KH, et al: Enhancing therapeutic efficacy of oncolytic herpes simplex virus-1 with integrin β1 blocking antibody OS2966. Mol Cancer Ther. 18:1127–1136. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Bazzoni R and Bentivegna A: Role of notch signaling pathway in glioblastoma pathogenesis. Cancers (Basel). 11:2922019. View Article : Google Scholar : PubMed/NCBI

58 

Yahyanejad S, King H, Iglesias VS, Granton PV, Barbeau LM, van Hoof SJ, Groot AJ, Habets R, Prickaerts J, Chalmers AJ, et al: NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. Oncotarget. 7:41251–41264. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K and Eberhart CG: Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells. Int J Cancer. 138:1246–1255. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J and Gill PS: KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood. 115:887–895. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Otani Y, Yoo JY, Chao S, Liu J, Jaime-Ramirez AC, Lee TJ, Hurwitz B, Yan Y, Dai H, Glorioso JC, et al: Oncolytic HSV-infected glioma cells activate NOTCH in adjacent tumor cells sensitizing tumors to gamma secretase inhibition. Clin Cancer Res. 26:2381–2392. 2020. View Article : Google Scholar : PubMed/NCBI

62 

de Gooijer MC, Zhang P, Weijer R, Buil LCM, Beijnen JH and van Tellingen O: The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors. Int J Cancer. 142:381–391. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Yoo JY, Swanner J, Otani Y, Nair M, Park F, Banasavadi-Siddegowda Y, Liu J, Jaime-Ramirez AC, Hong B, Geng F, et al: Oncolytic HSV therapy increases trametinib access to brain tumors and sensitizes them in vivo. Neuro Oncol. 21:1131–1140. 2019. View Article : Google Scholar : PubMed/NCBI

64 

Nguyen T, Avci NG, Shin DH, Martinez-Velez N and Jiang H: Tune up in situ autovaccination against solid tumors with oncolytic viruses. Cancers (Basel). 10:1712018. View Article : Google Scholar : PubMed/NCBI

65 

Yin J, Markert JM and Leavenworth JW: Modulation of the intratumoral immune landscape by oncolytic herpes simplex virus virotherapy. Front Oncol. 7:1362017. View Article : Google Scholar : PubMed/NCBI

66 

Ma W, He H and Wang H: Oncolytic herpes simplex virus and immunotherapy. BMC Immunol. 19:402018. View Article : Google Scholar : PubMed/NCBI

67 

Delwar ZM, Kuo Y, Wen YH, Rennie PS and Jia W: Oncolytic virotherapy blockade by microglia and macrophages requires STAT1/3. Cancer Res. 78:718–730. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Ikeda K, Ichikawa T, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR IV, Louis DN, Bartus RT, Hochberg FH and Chiocca EA: Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 5:881–887. 1999. View Article : Google Scholar : PubMed/NCBI

69 

Han J, Chen X, Chu J, Xu B, Meisen WH, Chen L, Zhang L, Zhang J, He X, Wang QE, et al: TGFβ treatment enhances glioblastoma virotherapy by inhibiting the innate immune response. Cancer Res. 75:5273–5282. 2015. View Article : Google Scholar : PubMed/NCBI

70 

Thorne AH, Meisen WH, Russell L, Yoo JY, Bolyard CM, Lathia JD, Rich J, Puduvalli VK, Mao H, Yu J, et al: Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance. Mol Ther. 22:1678–1687. 2014. View Article : Google Scholar : PubMed/NCBI

71 

Hua L and Wakimoto H: Oncolytic herpes simplex virus therapy for malignant glioma: Current approaches to successful clinical application. Expert Opin Biol Ther. 19:845–854. 2019. View Article : Google Scholar : PubMed/NCBI

72 

Duebgen M, Martinez-Quintanilla J, Tamura K, Hingtgen S, Redjal N, Wakimoto H and Shah K: Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy. J Natl Cancer Inst. 106:dju0902014. View Article : Google Scholar : PubMed/NCBI

73 

Simpson GR, Han Z, Liu B, Wang Y, Campbell G and Coffin RS: Combination of a fusogenic glycoprotein, prodrug activation, and oncolytic herpes simplex virus for enhanced local tumor control. Cancer Res. 66:4835–4842. 2006. View Article : Google Scholar : PubMed/NCBI

74 

Pan M, Zhang Y, Deng Z, Yan F and Hong G: Noninvasive and local delivery of adenoviral-mediated herpes simplex virus thymidine kinase to treat glioma through focused ultrasound-induced blood-brain barrier opening in rats. J Biomed Nanotechnol. 14:2031–2041. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Roy DG and Bell JC: Cell carriers for oncolytic viruses: Current challenges and future directions. Oncolytic Virother. 2:47–56. 2013.PubMed/NCBI

76 

Coukos G, Makrigiannakis A, Kang EH, Caparelli D, Benjamin I, Kaiser LR, Rubin SC, Albelda SM and Molnar-Kimber KL: Use of carrier cells to deliver a replication-selective herpes simplex virus-1 mutant for the intraperitoneal therapy of epithelial ovarian cancer. Clin Cancer Res. 5:1523–1537. 1999.PubMed/NCBI

77 

Lin W, Huang L, Li Y, Fang B, Li G, Chen L and Xu L: Mesenchymal stem cells and cancer: Clinical challenges and opportunities. Biomed Res Int. 2019:28208532019. View Article : Google Scholar : PubMed/NCBI

78 

Dührsen L, Hartfuss S, Hirsch D, Geiger S, Maire CL, Sedlacik J, Guenther C, Westphal M, Lamszus K, Hermann FG and Schmidt NO: Preclinical analysis of human mesenchymal stem cells: Tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma. Oncotarget. 10:6049–6061. 2019. View Article : Google Scholar

79 

Dewhirst MW and Secomb TW: Transport of drugs from blood vessels to tumour tissue. Nature reviews Cancer. 17:738–750. 2017. View Article : Google Scholar : PubMed/NCBI

80 

Ribeiro Franco PI, Rodrigues AP, de Menezes LB and Pacheco Miguel M: Tumor microenvironment components: Allies of cancer progression. Pathol Res Pract. 216:1527292020. View Article : Google Scholar : PubMed/NCBI

81 

Dickson PV, Hamner JB, Sims TL, Fraga CH, Ng CY, Rajasekeran S, Hagedorn NL, McCarville MB, Stewart CF and Davidoff AM: Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res. 13:3942–3950. 2007. View Article : Google Scholar : PubMed/NCBI

82 

Miller A, Nace R, Ayala-Breton CC, Steele M, Bailey K, Peng KW and Russell SJ: Perfusion pressure is a critical determinant of the intratumoral extravasation of oncolytic viruses. Mol Ther. 24:306–317. 2016. View Article : Google Scholar : PubMed/NCBI

83 

Hill C and Carlisle R: Achieving systemic delivery of oncolytic viruses. Expert Opin Drug Deliv. 16:607–620. 2019. View Article : Google Scholar : PubMed/NCBI

84 

Rampling R, Cruickshank G, Papanastassiou V, Nicoll J, Hadley D, Brennan D, Petty R, MacLean A, Harland J, McKie E, et al: Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther. 7:859–866. 2000. View Article : Google Scholar : PubMed/NCBI

85 

Papanastassiou V, Rampling R, Fraser M, Petty R, Hadley D, Nicoll J, Harland J, Mabbs R and Brown M: The potential for efficacy of the modified (ICP 34.5(−)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: A proof of principle study. Gene Ther. 9:398–406. 2002. View Article : Google Scholar : PubMed/NCBI

86 

Harrow S, Papanastassiou V, Harland J, Mabbs R, Petty R, Fraser M, Hadley D, Patterson J, Brown SM and Rampling R: HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: Safety data and long-term survival. Gene Ther. 11:1648–1658. 2004. View Article : Google Scholar : PubMed/NCBI

87 

Markert JM, Medlock MD, Rabkin SD, Gillespie GY, Todo T, Hunter WD, Palmer CA, Feigenbaum F, Tornatore C, Tufaro F and Martuza RL: Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a phase I trial. Gene Ther. 7:867–874. 2000. View Article : Google Scholar : PubMed/NCBI

88 

Markert JM, Liechty PG, Wang W, Gaston S, Braz E, Karrasch M, Nabors LB, Markiewicz M, Lakeman AD, Palmer CA, et al: Phase Ib trial of mutant herpes simplex virus G207 inoculated Pre-and Post-tumor resection for recurrent GBM. Mol Ther. 17:199–207. 2009. View Article : Google Scholar : PubMed/NCBI

89 

Markert JM, Razdan SN, Kuo HC, Cantor A, Knoll A, Karrasch M, Nabors LB, Markiewicz M, Agee BS, Coleman JM, et al: A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses. Mol Ther. 22:1048–1055. 2014. View Article : Google Scholar : PubMed/NCBI

90 

Bernstock JD, Wright Z, Bag AK, Gessler F, Gillespie GY, Markert JM, Friedman GK and Johnston JM: Stereotactic placement of intratumoral catheters for continuous infusion delivery of herpes simplex virus-1 G207 in pediatric malignant supratentorial brain tumors. World Neurosurgery. 122:e1592–e1598. 2019. View Article : Google Scholar : PubMed/NCBI

91 

Taguchi S, Fukuhara H and Todo T: Oncolytic virus therapy in Japan: Progress in clinical trials and future perspectives. Jpn J Clin Oncol. 49:201–209. 2019. View Article : Google Scholar : PubMed/NCBI

92 

Fukuhara H, Ino Y and Todo T: Oncolytic virus therapy: A new era of cancer treatment at dawn. Cancer Sci. 107:1373–1379. 2016. View Article : Google Scholar : PubMed/NCBI

93 

Desjardins A, Gromeier M, Herndon JE II, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, et al: Recurrent glioblastoma treated with recombinant poliovirus. N Engl J Med. 379:150–161. 2018. View Article : Google Scholar : PubMed/NCBI

94 

Jayawardena N, Poirier JT, Burga LN and Bostina M: Virus-receptor interactions and virus neutralization: Insights for oncolytic virus development. Oncolytic Virother. 9:1–15. 2020. View Article : Google Scholar : PubMed/NCBI

95 

Ning J and Wakimoto H: Oncolytic herpes simplex virus-based strategies: Toward a breakthrough in glioblastoma therapy. Front Microbiol. 5:3032014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou Z, Tian J, Zhang W, Xiang W, Ming Y, Chen L and Zhou J: Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review). Oncol Lett 22: 510, 2021.
APA
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., & Zhou, J. (2021). Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review). Oncology Letters, 22, 510. https://doi.org/10.3892/ol.2021.12771
MLA
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., Zhou, J."Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)". Oncology Letters 22.1 (2021): 510.
Chicago
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., Zhou, J."Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)". Oncology Letters 22, no. 1 (2021): 510. https://doi.org/10.3892/ol.2021.12771
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Z, Tian J, Zhang W, Xiang W, Ming Y, Chen L and Zhou J: Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review). Oncol Lett 22: 510, 2021.
APA
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., & Zhou, J. (2021). Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review). Oncology Letters, 22, 510. https://doi.org/10.3892/ol.2021.12771
MLA
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., Zhou, J."Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)". Oncology Letters 22.1 (2021): 510.
Chicago
Zhou, Z., Tian, J., Zhang, W., Xiang, W., Ming, Y., Chen, L., Zhou, J."Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)". Oncology Letters 22, no. 1 (2021): 510. https://doi.org/10.3892/ol.2021.12771
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team