Open Access

Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells

  • Authors:
    • Jing Fa
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  • Published online on: May 12, 2021     https://doi.org/10.3892/ol.2021.12785
  • Article Number: 524
  • Copyright: © Fa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dynamin 3 (DNM3) functions as a tumor suppressor in various malignancies. However, the underlying mechanism of DNM3 in cervical cancer remains to be elucidated. The present study aimed to indicate the function of DNM3 in cervical cancer. The expression of DNM3 in cervical tissues and cells was measured using bioinformatics analysis, immunohistochemistry and reverse transcription‑quantitative PCR. The pcDNA3.1 plasmid was used to overexpress DNM3 in SiHa and C33A cells. The effects of DNM3 overexpression on cell proliferation, migration, invasion and apoptosis was detected by the CCK-8, clone formation, transwell, flow cytometry and western blotting assays. In the present study, it was revealed that DNM3 was expressed at significantly low levels in cervical cancer tissues and cell lines compared with normal cervical tissues and cell lines. In addition, the low expression of DNM3 was significantly associated with high pathological grading of cervical cancer. The overall survival rate of patients with low DNM3 expression was significantly improved compared with patients with high DNM3 expression. In addition, the overexpression of DNM3 significantly inhibited the proliferation, migration and invasion of cervical carcinoma cells and induced cell apoptosis. The findings of the present study further revealed that the overexpression of DNM3 may inhibit cell migration and invasion by inactivating the epithelial mesenchymal transition process. In summary, the present study demonstrated that DNM3 was a tumor suppressor in cervical cancer progression and that it may serve as a potential prognostic biomarker for patients with cervical carcinoma.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
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Spandidos Publications style
Fa J: Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells. Oncol Lett 22: 524, 2021
APA
Fa, J. (2021). Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells. Oncology Letters, 22, 524. https://doi.org/10.3892/ol.2021.12785
MLA
Fa, J."Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells". Oncology Letters 22.1 (2021): 524.
Chicago
Fa, J."Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells". Oncology Letters 22, no. 1 (2021): 524. https://doi.org/10.3892/ol.2021.12785