Open Access

Cytochrome P450: Implications for human breast cancer (Review)

  • Authors:
    • Bin Luo
    • Dandan Yan
    • Honglin Yan
    • Jingping Yuan
  • View Affiliations

  • Published online on: May 24, 2021     https://doi.org/10.3892/ol.2021.12809
  • Article Number: 548
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The treatment options for breast cancer include endocrine therapy, targeted therapy and chemotherapy. However, some patients with triple‑negative breast cancer cannot benefit from these methods. Therefore, novel therapeutic targets should be developed. The cytochrome P450 enzyme (CYP) is a crucial metabolic oxidase, which is involved in the metabolism of endogenous and exogenous substances in the human body. Some products undergoing the metabolic pathway of the CYP enzyme, such as hydroxylated polychlorinated biphenyls and 4‑chlorobiphenyl, are toxic to humans and are considered to be potential carcinogens. As a class of multi‑gene superfamily enzymes, the subtypes of CYPs are selectively expressed in breast cancer tissues, especially in the basal‑like type. In addition, CYPs are essential for the activation or inactivation of anticancer drugs. The association between CYP expression and cancer risk, tumorigenesis, progression, metastasis and prognosis has been widely reported in basic and clinical studies. The present review describes the current findings regarding the importance of exploring metabolic pathways of CYPs and gene polymorphisms for the development of vital therapeutic targets for breast cancer.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Luo B, Yan D, Yan H and Yuan J: Cytochrome P450: Implications for human breast cancer (Review). Oncol Lett 22: 548, 2021
APA
Luo, B., Yan, D., Yan, H., & Yuan, J. (2021). Cytochrome P450: Implications for human breast cancer (Review). Oncology Letters, 22, 548. https://doi.org/10.3892/ol.2021.12809
MLA
Luo, B., Yan, D., Yan, H., Yuan, J."Cytochrome P450: Implications for human breast cancer (Review)". Oncology Letters 22.1 (2021): 548.
Chicago
Luo, B., Yan, D., Yan, H., Yuan, J."Cytochrome P450: Implications for human breast cancer (Review)". Oncology Letters 22, no. 1 (2021): 548. https://doi.org/10.3892/ol.2021.12809