Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells Corrigendum in /10.3892/ol.2023.13785

Gong,Pihai; Xu,Ying; Liu,Min; Shen,Xiaohui; Mao,Yuhang; Li,Yiping; Zhang,Kun; Yu,Shenling; Fan,Hong

doi:10.3892/ol.2021.12818

Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells

Corrigendum in: /10.3892/ol.2023.13785

Authors:
- Pihai Gong
- Ying Xu
- Min Liu
- Xiaohui Shen
- Yuhang Mao
- Yiping Li
- Kun Zhang
- Shenling Yu
- Hong Fan
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Affiliations: Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, P.R. China, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu 210018, P.R. China, Department of Pathology, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Medicine, The Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 154000, P.R. China
Published online on: May 24, 2021 https://doi.org/10.3892/ol.2021.12818
Article Number: 557
Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) serve an important role in the progression of cancer. LINC00659 was recently identified as a novel oncogenic lncRNA involved in colon cancer cell proliferation via modulating the cell cycle. However, the function of LINC00659 in other types of cancer, especially in gastric cancer (GC), remains unknown. In the present study, bioinformatics analysis combined with cell experiments were performed to explore the function of LINC00659 in GC. It was revealed that LINC00659 expression was significantly upregulated in GC tissues and cell lines. Increased levels of LINC00659 were associated with advanced tumor stage and unfavorable prognosis of patients with GC. Additionally, upregulated LINC00659 expression promoted the migration and invasion of GC cells. Further analysis using a bioinformatics method revealed that matrix metalloproteinase 15 and IQ motif‑containing GTPase activating protein 3 were potential downstream targets of LINC00659 involved in tumor metastasis, although the precise underlying mechanism requires further exploration.

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