Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling
Affiliations: Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305‑8575, Japan, Division of Gastroenterology, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 309‑1793, Japan, BioThinkTank Co. Ltd., Yokohama, Kanagawa 220‑0012, Japan
- Published online on: May 25, 2021 https://doi.org/10.3892/ol.2021.12819
- Article Number: 558
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.