Clinical value of microRNA‑135a and MMP‑13 in colon cancer
- Xinjun Zhou
- Dong Yang
- Xiping Ding
- Peisheng Xu
Affiliations: Department of General Surgery, Sheng Li Oil Field Central Hospital, Dongying, Shandong 257000, P.R. China
- Published online on: June 3, 2021 https://doi.org/10.3892/ol.2021.12844
Copyright: © Zhou
et al. This is an open access article distributed under the
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The aim of the present study was to investigate the expression and prognostic value of microRNA‑135a (miR‑135a) and matrix metalloproteinase‑13 (MMP‑13) in serum of colon cancer (CC). A total of 117 cases of patients admitted to Sheng Li Oil Field Central Hospital from May 2015 to May 2017 were enrolled in the research group (RG), and 120 cases of subjects undergoing normal health examination were included in the control group (CG). The expression of miR‑135 and MMP‑13 in peripheral blood of the two groups were compared, and their values were analyzed. It was found that miR‑135a was decreased and MMP‑13 was increased in the RG (P<0.050), both of which were closely related to the pathological features and prognosis of CC (P<0.050), and was also significantly correlated with CEA (P<0.001). ROC curve analysis showed that both of them had great predictive value for the occurrence, prognosis and death of CC. In conclusion, miR‑135a was low expressed in CC, while MMP‑13 was increased in CC, suggesting that the combined detection of the two had a good diagnostic effect on the occurrence of CC, and was closely related to the prognosis of CCC patients, which might be an excellent potential indicator for the diagnosis and treatment of CC in the future.