Open Access

Melatonin inhibits gallbladder cancer cell migration and invasion via ERK‑mediated induction of epithelial‑to‑mesenchymal transition

  • Authors:
    • Hongwei Tang
    • Xiaoyi Shi
    • Pengfei Zhu
    • Wenzhi Guo
    • Jie Li
    • Bing Yan
    • Shuijun Zhang
  • View Affiliations

  • Published online on: June 15, 2021     https://doi.org/10.3892/ol.2021.12870
  • Article Number: 609
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melatonin is a naturally occurring molecule secreted by the pineal gland that exhibits antitumor properties and prevents the development of human cancer. However, little is known regarding the effects of melatonin on gallbladder cancer (GBC) cells. The present study aimed to investigate the role of melatonin on the prevention of GBC cell invasion. The GBC cell line, GBC‑SD, was treated with different concentrations of melatonin for different time periods, and the data indicated that melatonin markedly inhibited the invasion of GBC cells. Following treatment of GBC cells with melatonin, the protein levels of the epithelial marker, E‑cadherin, significantly increased, while the expression levels of the mesenchymal markers, N‑cadherin, Snail and vimentin, notably decreased. In addition, melatonin inhibited the phosphorylation of ERK1/2. Following treatment of the cells with the ERK activator, tert‑Butylhydroquinone, the anti‑invasive effects of melatonin were reversed by rescuing epithelial‑to‑mesenchymal transition in GBC cells. Taken together, these results suggest that melatonin inhibits GBC invasiveness by blocking the ERK signaling pathway. Thus, melatonin may be used as a potential novel cancer therapeutic drug for the treatment of GBC.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tang H, Shi X, Zhu P, Guo W, Li J, Yan B and Zhang S: Melatonin inhibits gallbladder cancer cell migration and invasion via ERK‑mediated induction of epithelial‑to‑mesenchymal transition. Oncol Lett 22: 609, 2021
APA
Tang, H., Shi, X., Zhu, P., Guo, W., Li, J., Yan, B., & Zhang, S. (2021). Melatonin inhibits gallbladder cancer cell migration and invasion via ERK‑mediated induction of epithelial‑to‑mesenchymal transition. Oncology Letters, 22, 609. https://doi.org/10.3892/ol.2021.12870
MLA
Tang, H., Shi, X., Zhu, P., Guo, W., Li, J., Yan, B., Zhang, S."Melatonin inhibits gallbladder cancer cell migration and invasion via ERK‑mediated induction of epithelial‑to‑mesenchymal transition". Oncology Letters 22.2 (2021): 609.
Chicago
Tang, H., Shi, X., Zhu, P., Guo, W., Li, J., Yan, B., Zhang, S."Melatonin inhibits gallbladder cancer cell migration and invasion via ERK‑mediated induction of epithelial‑to‑mesenchymal transition". Oncology Letters 22, no. 2 (2021): 609. https://doi.org/10.3892/ol.2021.12870