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Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma

  • Authors:
    • Isaku Kohama
    • Naofumi Asano
    • Juntaro Matsuzaki
    • Yusuke Yamamoto
    • Tomofumi Yamamoto
    • Ryou-U Takahashi
    • Eisuke Kobayashi
    • Satoko Takizawa
    • Hiromi Sakamoto
    • Ken Kato
    • Hiroyuki Fujimoto
    • Hirotaka Chikuda
    • Akira Kawai
    • Takahiro Ochiya
  • View Affiliations / Copyright

    Affiliations: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104‑0045, Japan, Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160‑8582, Japan, Department of Cellular and Molecular Biology, Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734‑8553, Japan, Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104‑0045, Japan, New Frontiers Research Institute, Toray Industries, Kamakura, Kanagawa 247‑8555, Japan, Department of Clinical Genomics, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo 104‑0045, Japan, Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo 104‑0045, Japan, Department of Urology, National Cancer Center Hospital, Tokyo 104‑0045, Japan, Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371‑8511, Japan
    Copyright: © Kohama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 623
    |
    Published online on: June 29, 2021
       https://doi.org/10.3892/ol.2021.12884
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Abstract

Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis of sarcoma is limited, and designing effective treatments is difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, the roles of miRNAs and exosomes in sarcoma remain unclear. The present analysis of tissue and serum miRNA expression in osteosarcoma, Ewing's sarcoma and dedifferentiated liposarcoma (DDLPS) identified miR‑1246, ‑4532, ‑4454, ‑619‑5p and ‑6126 as biomarkers for DDLPS. These miRNAs were highly expressed in human DDLPS cell lines and exosomes, suggesting that they are secreted from DDLPS tissues. The present results suggested that specific miRNAs may be used as biomarkers for early diagnosis or treatment targets in DDLPS.
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Copy and paste a formatted citation
Spandidos Publications style
Kohama I, Asano N, Matsuzaki J, Yamamoto Y, Yamamoto T, Takahashi R, Kobayashi E, Takizawa S, Sakamoto H, Kato K, Kato K, et al: Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma. Oncol Lett 22: 623, 2021.
APA
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R. ... Ochiya, T. (2021). Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma. Oncology Letters, 22, 623. https://doi.org/10.3892/ol.2021.12884
MLA
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., Fujimoto, H., Chikuda, H., Kawai, A., Ochiya, T."Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma". Oncology Letters 22.2 (2021): 623.
Chicago
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., Fujimoto, H., Chikuda, H., Kawai, A., Ochiya, T."Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma". Oncology Letters 22, no. 2 (2021): 623. https://doi.org/10.3892/ol.2021.12884
Copy and paste a formatted citation
x
Spandidos Publications style
Kohama I, Asano N, Matsuzaki J, Yamamoto Y, Yamamoto T, Takahashi R, Kobayashi E, Takizawa S, Sakamoto H, Kato K, Kato K, et al: Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma. Oncol Lett 22: 623, 2021.
APA
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R. ... Ochiya, T. (2021). Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma. Oncology Letters, 22, 623. https://doi.org/10.3892/ol.2021.12884
MLA
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., Fujimoto, H., Chikuda, H., Kawai, A., Ochiya, T."Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma". Oncology Letters 22.2 (2021): 623.
Chicago
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., Fujimoto, H., Chikuda, H., Kawai, A., Ochiya, T."Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma". Oncology Letters 22, no. 2 (2021): 623. https://doi.org/10.3892/ol.2021.12884
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