Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Aqueous extracts of Sanghuangporus vaninii induce S‑phase arrest and apoptosis in human melanoma A375 cells

  • Authors:
    • Taihen Yu
    • Shi Zhong
    • Yuqing Sun
    • Haiyan Sun
    • Weiguo Chen
    • Yougui Li
    • Jianxun Zhu
    • Longxi Lu
    • Jinxi Huo
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, P.R. China, Haining Economic Crop Technical Service Station, Haining Agricultural and Rural Bureau, Haining, Zhejiang 314400, P.R. China, Department of Environment & Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 628
    |
    Published online on: June 30, 2021
       https://doi.org/10.3892/ol.2021.12889
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sanghuangporus vaninii, also called ‘Sanghuang’ mushroom in Chinese, has various medicinal uses, but its effects on human melanoma cells have not been reported. The present study investigated the inhibitory ability and potential anticancer mechanism of the aqueous extracts of S. vaninii (SH). The results revealed that SH inhibited the proliferation of A375 human melanoma cells in a dose‑dependent manner, and flow cytometry analysis suggested that SH induced A375 cell cycle arrest at S phase and apoptosis. Reverse transcription‑quantitative PCR, western blotting and immunofluorescence analyses indicated that SH induced S‑phase arrest by upregulating p21 expression, and p21 inhibited the expression of cyclin‑cyclin‑dependent kinases complexes at both the RNA and protein levels. In addition, SH induced apoptosis of A375 cells by inhibiting the expression levels of the anti‑apoptosis gene Bcl‑2. Therefore, the results suggested that SH may be a potential candidate for the treatment of human melanoma, thus providing new ideas for developing drugs that target melanoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Olbryt M: Molecular background of skin melanoma development and progression: Therapeutic implications. Postepy Dermatol Alergol. 36:129–138. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Davis LE, Shalin SC and Tackett AJ: Current state of melanoma diagnosis and treatment. Cancer Biol Ther. 20:1366–1379. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Lee JH, Cho SM, Kim HM, Hong ND and Yoo ID: Immunostimulating activity of polysaccharides from mycelia of Phellinus linteus grown under different culture conditions. J Microbiol Biotechnol. 7:2–55. 1997.

4 

Chen H, Tian T, Miao H and Zhao YY: Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review. Fitoterapia. 113:6–26. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Chen W, Tan H, Liu Q, Zheng X, Zhang H, Liu Y and Xu L: A review: The bioactivities and pharmacological applications of Phellinus linteus. Molecules. 24:18882019. View Article : Google Scholar : PubMed/NCBI

6 

Huo J, Zhong S, Du X, Cao Y, Wang W, Sun Y, Tian Y, Zhu J, Chen J, Xuan L, et al: Whole-genome sequence of Phellinus gilvus (mulberry Sanghuang) reveals its unique medicinal values. J Adv Res. 24:325–335. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Meera CR, Janardhanan KK and Karunagaran D: Antiproliferative and apoptotic activities of the medicinal mushroom Phellinus rimosus (Agaricomycetes) on HCT116 human colorectal carcinoma cells. Int J Med Mushrooms. 20:935–945. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Wang FF, Shi C, Yang Y, Fang Y, Sheng L and Li N: Medicinal mushroom Phellinus igniarius induced cell apoptosis in gastric cancer SGC-7901 through a mitochondria-dependent pathway. Biomed Pharmacother. 102:18–25. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Im KH, Baek SA, Choi J and Lee TS: Antioxidant, anti-melanogenic and anti-wrinkle effects of Phellinus vaninii. Mycobiology. 47:494–505. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Bae JS, Jang KH, Yim H and Jin HK: Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice. Cancer Lett. 218:43–52. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Bae JS, Jang KH, Yim H, Park SC and Jin HK: Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice. World J Gastroenterol. 11:577–579. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Zhong S, Li YG, Ji DF, Lin TB and Lv ZQ: Protocatechualdehyde induces S-phase arrest and apoptosis by stimulating the p27KIP1-Cyclin A/D1-CDK2 and mitochondrial apoptotic pathways in HT-29 Cells. Molecules. 21:9342016. View Article : Google Scholar : PubMed/NCBI

13 

Chao W, Deng JS, Li PY, Liang YC and Huang GJ: 3,4-Dihydroxybenzalactone suppresses human non-small cell lung carcinoma cells metastasis via suppression of epithelial to mesenchymal transition, ROS-mediated PI3K/AKT/MAPK/MMP and NFκB signaling pathways. Molecules. 22:5372017. View Article : Google Scholar : PubMed/NCBI

14 

Liu YJ, Lyu JL, Kuo YH, Chiu CY, Wen KC and Chiang HM: The anti-melanogenesis effect of 3,4-dihydroxybenzalacetone through downregulation of melanosome maturation and transportation in B16F10 and human epidermal melanocytes. Int J Mol Sci. 22:28232021. View Article : Google Scholar : PubMed/NCBI

15 

Yang Y, Zhang L, Chen Q, Lu WL and Li N: Antitumor effects of extract of the oak bracket medicinal mushroom, Phellinus baumii (Agaricomycetes), on human melanoma cells A375 in vitro and in vivo. Int J Med Mushrooms. 22:197–209. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Zhong S, Jin Q, Yu T, Zhu J and Li Y: Phellinus gilvus derived protocatechualdehyde induces G0/G1 phase arrest and apoptosis in murine B16 F10 cells. Mol Med Rep. 21:1107–1114. 2020.PubMed/NCBI

17 

Huo J, Sun Y, Zhong S, Li Y, Yang R, Xia L, Wang J, Zhang M and Zhu J: Safety evaluation of aqueous extracts of Sanghuangporus vaninii fruiting body in Sprague-Dawley rats. Food Sci Nutr. 8:5107–5113. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Harvey AL, Edrada-Ebel R and Quinn RJ: The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 14:111–129. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Moussa RS, Park KC, Kovacevic Z and Richardson DR: Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity. Free Radic Biol Med. 133:276–294. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Diaz-Moralli S, Tarrado-Castellarnau M, Miranda A and Cascante M: Targeting cell cycle regulation in cancer therapy. Pharmacol Ther. 138:255–271. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Al Bitar S and Gali-Muhtasib H: The role of the cyclin dependent kinase inhibitor p21cip1/waf1 in targeting cancer: Molecular mechanisms and novel therapeutics. Cancers (Basel). 11:E14752019. View Article : Google Scholar : PubMed/NCBI

23 

Golias CH, Charalabopoulos A and Charalabopoulos K: Cell proliferation and cell cycle control: A mini review. Int J Clin Pract. 58:1134–1141. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Du Toit A: Cell death: Balance through a bivalent regulator. Nat Rev Mol Cell Biol. 14:546–547. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Singh R, Letai A and Sarosiek K: Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol. 20:175–193. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu T, Zhong S, Sun Y, Sun H, Chen W, Li Y, Zhu J, Lu L and Huo J: Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells. Oncol Lett 22: 628, 2021.
APA
Yu, T., Zhong, S., Sun, Y., Sun, H., Chen, W., Li, Y. ... Huo, J. (2021). Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells. Oncology Letters, 22, 628. https://doi.org/10.3892/ol.2021.12889
MLA
Yu, T., Zhong, S., Sun, Y., Sun, H., Chen, W., Li, Y., Zhu, J., Lu, L., Huo, J."Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells". Oncology Letters 22.2 (2021): 628.
Chicago
Yu, T., Zhong, S., Sun, Y., Sun, H., Chen, W., Li, Y., Zhu, J., Lu, L., Huo, J."Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells". Oncology Letters 22, no. 2 (2021): 628. https://doi.org/10.3892/ol.2021.12889
Copy and paste a formatted citation
x
Spandidos Publications style
Yu T, Zhong S, Sun Y, Sun H, Chen W, Li Y, Zhu J, Lu L and Huo J: Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells. Oncol Lett 22: 628, 2021.
APA
Yu, T., Zhong, S., Sun, Y., Sun, H., Chen, W., Li, Y. ... Huo, J. (2021). Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells. Oncology Letters, 22, 628. https://doi.org/10.3892/ol.2021.12889
MLA
Yu, T., Zhong, S., Sun, Y., Sun, H., Chen, W., Li, Y., Zhu, J., Lu, L., Huo, J."Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells". Oncology Letters 22.2 (2021): 628.
Chicago
Yu, T., Zhong, S., Sun, Y., Sun, H., Chen, W., Li, Y., Zhu, J., Lu, L., Huo, J."Aqueous extracts of <em>Sanghuangporus vaninii</em> induce S‑phase arrest and apoptosis in human melanoma A375 cells". Oncology Letters 22, no. 2 (2021): 628. https://doi.org/10.3892/ol.2021.12889
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team