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Review

Advances in the role of autophagy in the development of retinoblastoma (Review)

  • Authors:
    • Teng Wan
    • Mingyuan Fu
    • Zhuan Wu
    • Xue Gao
    • Shouhong Zhou
  • View Affiliations / Copyright

    Affiliations: Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P.R. China, Department of Physiology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Biochemistry, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
  • Article Number: 632
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    Published online on: July 1, 2021
       https://doi.org/10.3892/ol.2021.12893
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Abstract

Autophagy is a feedback regulatory mechanism of cells to external stress, which helps cells to adapt to changes in physiological conditions and environmental stress. Autophagy possesses a variety of target genes that control a wide range of signaling pathways. Maintenance of an appropriate level of autophagy is essential for the growth, metastasis and characteristics of tumors. Retinoblastoma (RB) is the most common primary intraocular malignant tumor found in the eyes of children following exposure to extreme environmental factors, such as mitochondrial defects, oxidative stress and excessive autophagy; this leads to the development of DNA damage and progressive loss of the function of the eye, which results in the occurrence of RB. Recent studies have documented the involvement of autophagy in the transformation, occurrence and metastasis of RB. High or low levels of autophagy exert notably promotive or repressive effects on the development, invasion, drug resistance and survival of RB, respectively. The present review reports the research progress on the association between autophagy and RB.
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1 

Fabian ID, Onadim Z, Karaa E, Duncan C, Chowdhury T, Scheimberg I, Ohnuma SI, Reddy MA and Sagoo MS: The management of retinoblastoma. Oncogene. 37:1551–1560. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Mallipatna A, Marino M and Singh AD: Genetics of Retinoblastoma. Asia Pac J Ophthalmol (Phila). 5:260–264. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Doherty J and Baehrecke EH: Life, death and autophagy. Nat Cell Biol. 20:1110–1117. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Bartsch K, Knittler K, Borowski C, Rudnik S, Damme M, Aden K, Spehlmann ME, Frey N, Saftig P, Chalaris A, et al: Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy. Hum Mol Genet. 26:3960–3972. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K and Mizushima N: Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 25:795–800. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Kimmelman AC and White E: Autophagy and tumor metabolism. Cell Metab. 25:1037–1043. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Poillet-Perez L and White E: Role of tumor and host autophagy in cancer metabolism. Genes Dev. 33:610–619. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Eskelinen EL: Autophagy: Supporting cellular and organismal homeostasis by self-eating. Int J Biochem Cell Biol. 111:1–10. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Zhou S, Chen X, Xue R, Zhou Q, Hu P, Ouyang X, Dai T, Zhu W and Tian S: Autophagy is involved in the pathogenesis of experimental autoimmune neuritis in rats. Neuroreport. 27:337–344. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Parzych KR and Klionsky DJ: An overview of autophagy: Morphology, mechanism, and regulation. Antioxid Redox Signal. 20:460–473. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH and Karin M: Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci USA. 112:E6166–E6174. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Honda S, Arakawa S, Yamaguchi H, Torii S, Tajima Sakurai H, Tsujioka M, Murohashi M and Shimizu S: Association between Atg5-independent alternative autophagy and neurodegenerative diseases. J Mol Biol. 432:2622–2632. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Keller MD, Torres VJ and Cadwell K: Autophagy and microbial pathogenesis. Cell Death Differ. 27:872–886. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Rybstein MD, Bravo-San Pedro JM, Kroemer G and Galluzzi L: The autophagic network and cancer. Nat Cell Biol. 20:243–251. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Mariño G, Niso-Santano M, Baehrecke EH and Kroemer G: Self-consumption: The interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 15:81–94. 2014. View Article : Google Scholar

16 

Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Nazio F, Strappazzon F, Antonioli M, Bielli P, Cianfanelli V, Bordi M, Gretzmeier C, Dengjel J, Piacentini M, Fimia GM, et al: mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol. 15:406–416. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Li Z, Tian X, Ji X, Wang J, Chen H, Wang D and Zhang X: ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle. PLoS Biol. 18:e30002882020. View Article : Google Scholar : PubMed/NCBI

19 

Araki Y, Ku WC, Akioka M, May AI, Hayashi Y, Arisaka F, Ishihama Y and Ohsumi Y: Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol. 203:299–313. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Kotani T, Kirisako H, Koizumi M, Ohsumi Y and Nakatogawa H: The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation. Proc Natl Acad Sci USA. 115:10363–10368. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F and Ohsumi Y: The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 282:37298–37302. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Guo H, Chitiprolu M, Roncevic L, Javalet C, Hemming FJ, Trung MT, Meng L, Latreille E, Tanese de Souza C, McCulloch D, et al: Atg5 Disassociates the V1V0-ATPase to Promote exosome production and tumor metastasis independent of canonical macroautophagy. Dev Cell. 43:716–730.e7. 2017. View Article : Google Scholar : PubMed/NCBI

23 

B'Chir W, Maurin AC, Carraro V, Averous J, Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P and Bruhat A: The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res. 41:7683–7699. 2013. View Article : Google Scholar

24 

Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, et al: TFEB links autophagy to lysosomal biogenesis. Science. 332:1429–1433. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Russell RC, Yuan HX and Guan KL: Autophagy regulation by nutrient signaling. Cell Res. 24:42–57. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Pietrocola F, Lachkar S, Enot DP, Niso-Santano M, Bravo-San Pedro JM, Sica V, Izzo V, Maiuri MC, Madeo F, Mariño G, et al: Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 22:509–516. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Wang Y, Zhang N, Zhang L, Li R, Fu W, Ma K, Li X, Wang L, Wang J, Zhang H, et al: Autophagy regulates chromatin ubiquitination in DNA damage response through elimination of SQSTM1/p62. Mol Cell. 63:34–48. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Huang T, Song X, Yang Y, Wan X, Alvarez AA, Sastry N, Feng H, Hu B and Cheng SY: Autophagy and Hallmarks of Cancer. Crit Rev Oncog. 23:247–267. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K and Mizushima N: Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 25:795–800. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, et al: PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci USA. 107:15145–15150. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Li L, Ishdorj G and Gibson SB: Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment. Free Radic Biol Med. 53:1399–1410. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Pattingre S, Bauvy C and Codogno P: Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem. 278:16667–16674. 2003. View Article : Google Scholar : PubMed/NCBI

33 

White E: The role for autophagy in cancer. J Clin Invest. 125:42–46. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, et al: Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25:717–729. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, et al: Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 25:460–470. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Strohecker AM and White E: Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy. 10:384–385. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, et al: Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 27:1447–1461. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J, Hart LS, Levi S, Hu J, Zhang G, et al: Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. J Clin Invest. 124:1406–1417. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Levy JM, Thompson JC, Griesinger AM, Amani V, Donson AM, Birks DK, Morgan MJ, Mirsky DM, Handler MH, Foreman NK, et al: Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. Cancer Discov. 4:773–780. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, et al: Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524:361–365. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Liu K, Lee J, Kim JY, Wang L, Tian Y, Chan ST, Cho C, Machida K, Chen D and Ou JJ: Mitophagy controls the activities of tumor suppressor p53 to regulate hepatic cancer stem cells. Mol Cell. 68:281–292.e5. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Wu HB, Yang S, Weng HY, Chen Q, Zhao XL, Fu WJ, Niu Q, Ping YF, Wang JM, Zhang X, et al: Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells. Autophagy. 13:1528–1542. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Amaravadi RK, Kimmelman AC and Debnath J: Targeting autophagy in cancer: Recent advances and future directions. Cancer Discov. 9:1167–1181. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Soliman SE, Racher H, Zhang C, MacDonald H and Gallie BL: Genetics and Molecular Diagnostics in Retinoblastoma - An Update. Asia Pac J Ophthalmol (Phila). 6:197–207. 2017.PubMed/NCBI

45 

Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, et al: Inactivation of the p53 pathway in retinoblastoma. Nature. 444:61–66. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Dimaras H, Khetan V, Halliday W, Orlic M, Prigoda NL, Piovesan B, Marrano P, Corson TW, Eagle RC Jr, Squire JA, et al: Loss of RB1 induces non-proliferative retinoma: Increasing genomic instability correlates with progression to retinoblastoma. Hum Mol Genet. 17:1363–1372. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Liu Y, Wan ST, Zhang P, Zhang WX, Zheng JL, Lin JX and Li YP: Expression levels of autophagy related proteins and their prognostic significance in retinocytoma and retinoblastoma. Int J Ophthalmol. 7:594–601. 2014.PubMed/NCBI

48 

Indovina P, Acquaviva A, De Falco G, Rizzo V, Onnis A, Luzzi A, Giorgi F, Hadjistilianou T, Toti P, Tomei V, et al: Downregulation and aberrant promoter methylation of p16INK4A: A possible novel heritable susceptibility marker to retinoblastoma. J Cell Physiol. 223:143–150. 2010.PubMed/NCBI

49 

Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White E, Xu J, McDonnell TJ, Shinojima N and Fueyo J: The RB-E2F1 pathway regulates autophagy. Cancer Res. 70:7882–7893. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Biasoli D, Kahn SA, Cornélio TA, Furtado M, Campanati L, Chneiweiss H, Moura-Neto V and Borges HL: Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide. Cell Death Dis. 4:e7672013. View Article : Google Scholar : PubMed/NCBI

51 

Chen N and Karantza-Wadsworth V: Role and regulation of autophagy in cancer. Biochim Biophys Acta. 1793:1516–1523. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Zhu X, Li X and Chen Z: Inhibition of anticancer growth in Retinoblastoma cells by naturally occurring sesquiterpene nootkatone is mediated via autophagy, endogenous ROS production, cell cycle arrest and inhibition of NF-κB signalling pathway. J BUON. 25:427–431. 2020.PubMed/NCBI

53 

Zhang M, Zhou YF, Gong JY, Gao CB and Li SL: Expression of autophagy-related protein LC3B, p62, and cytoplasmic p53 in human retinoblastoma tissues. Eur Rev Med Pharmacol Sci. 20:3152–3160. 2016.PubMed/NCBI

54 

Komatsu M and Ichimura Y: Physiological significance of selective degradation of p62 by autophagy. FEBS Lett. 584:1374–1378. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Li YJ, Lei YH, Yao N, Wang CR, Hu N, Ye WC, Zhang DM and Chen ZS: Autophagy and multidrug resistance in cancer. Chin J Cancer. 36:522017. View Article : Google Scholar : PubMed/NCBI

56 

Yoshida GJ: Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: From pathophysiology to treatment. J Hematol Oncol. 10:672017. View Article : Google Scholar : PubMed/NCBI

57 

Cai CL, Jin L, Lang XL and Li BL: Long noncoding RNA XIST regulates cardiomyocyte apoptosis by targeting miR-873-5p/MCL1 axis. Eur Rev Med Pharmacol Sci. 24:12878–12886. 2020.PubMed/NCBI

58 

Liu K, Huang J, Xie M, Yu Y, Zhu S, Kang R, Cao L, Tang D and Duan X: MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell. Autophagy. 10:442–452. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Yao L, Yang L, Song H, Liu TG and Yan H: Silencing of lncRNA XIST suppresses proliferation and autophagy and enhances vincristine sensitivity in retinoblastoma cells by sponging miR-204-5p. Eur Rev Med Pharmacol Sci. 24:3526–3537. 2020.PubMed/NCBI

60 

Wang Y, Xin D and Zhou L: LncRNA LINC00152 increases the aggressiveness of human retinoblastoma and enhances carboplatin and adriamycin resistance by regulating miR-613/Yes-associated protein 1 (YAP1) axis. Med Sci Monit. 26:e920886–1-e920886-17. 2020. View Article : Google Scholar : PubMed/NCBI

61 

Huang J, Yang Y, Fang F and Liu K: MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation. J Cell Biochem. 119:3853–3863. 2018. View Article : Google Scholar : PubMed/NCBI

62 

Liu Y, Su J and Wang LH: Role of autophagy in cisplatin resistance of retinoblastoma Y79 cells and its mechanism. Zhongliu Fangzhi Yanjiu. 45:517–522. 2018.PubMed/NCBI

63 

Sun J, Feng D, Xi H, Luo J, Zhou Z, Liu Q, Chen Y and Shao Q: CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy. Mol Oncol. 14:1740–1759. 2020. View Article : Google Scholar : PubMed/NCBI

64 

Liang Y, Chen X and Liang Z: MicroRNA-320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor-1α. Exp Ther Med. 14:2367–2372. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Kong M, Han Y, Zhao Y and Zhang H: miR-512-3p overcomes resistance to cisplatin in retinoblastoma by promoting apoptosis induced by endoplasmic reticulum stress. Med Sci Monit. 26:e923817–1-e923817-10. 2020. View Article : Google Scholar : PubMed/NCBI

66 

Yi QY, Bai ZS, Cai B, Chen N, Chen LS, Yuan T and Mao JH: HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncol Rep. 40:682–692. 2018.PubMed/NCBI

67 

Li M, Zhang D, Cheng J, Liang J and Yu F: Ginsenoside Rh2 inhibits proliferation but promotes apoptosis and autophagy by down-regulating microRNA-638 in human retinoblastoma cells. Exp Mol Pathol. 108:17–23. 2019. View Article : Google Scholar : PubMed/NCBI

68 

Yin L, Sun Z, Ren Q, Su X and Zhang D: Methyl eugenol induces potent anticancer effects in RB355 human retinoblastoma cells by inducing autophagy, cell cycle arrest and inhibition of PI3K/mTOR/Akt signalling pathway. J BUON. 23:1174–1178. 2018.PubMed/NCBI

69 

Li X, Zhu X, Xu C and Wu J: 2-Methyl 2-butanol suppresses human retinoblastoma cells through cell cycle arrest and autophagy. Braz J Med Biol Res. 51:e68892018. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Wan T, Fu M, Wu Z, Gao X and Zhou S: Advances in the role of autophagy in the development of retinoblastoma (Review). Oncol Lett 22: 632, 2021.
APA
Wan, T., Fu, M., Wu, Z., Gao, X., & Zhou, S. (2021). Advances in the role of autophagy in the development of retinoblastoma (Review). Oncology Letters, 22, 632. https://doi.org/10.3892/ol.2021.12893
MLA
Wan, T., Fu, M., Wu, Z., Gao, X., Zhou, S."Advances in the role of autophagy in the development of retinoblastoma (Review)". Oncology Letters 22.2 (2021): 632.
Chicago
Wan, T., Fu, M., Wu, Z., Gao, X., Zhou, S."Advances in the role of autophagy in the development of retinoblastoma (Review)". Oncology Letters 22, no. 2 (2021): 632. https://doi.org/10.3892/ol.2021.12893
Copy and paste a formatted citation
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Spandidos Publications style
Wan T, Fu M, Wu Z, Gao X and Zhou S: Advances in the role of autophagy in the development of retinoblastoma (Review). Oncol Lett 22: 632, 2021.
APA
Wan, T., Fu, M., Wu, Z., Gao, X., & Zhou, S. (2021). Advances in the role of autophagy in the development of retinoblastoma (Review). Oncology Letters, 22, 632. https://doi.org/10.3892/ol.2021.12893
MLA
Wan, T., Fu, M., Wu, Z., Gao, X., Zhou, S."Advances in the role of autophagy in the development of retinoblastoma (Review)". Oncology Letters 22.2 (2021): 632.
Chicago
Wan, T., Fu, M., Wu, Z., Gao, X., Zhou, S."Advances in the role of autophagy in the development of retinoblastoma (Review)". Oncology Letters 22, no. 2 (2021): 632. https://doi.org/10.3892/ol.2021.12893
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