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Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma

  • Authors:
    • Yu-Yan Lan
    • Ying-Hui Chen
    • Cheng Liu
    • Kuo-Lung Tung
    • Yen-Ting Wu
    • Sheng-Chieh Lin
    • Chin-Han Wu
    • Hong-Yi Chang
    • Yung-Chia Chen
    • Bu-Miin Huang
  • View Affiliations / Copyright

    Affiliations: Department of Physical Therapy, Shu‑Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan, R.O.C., Department of Anesthesia, Chi‑Mei Medical Center, Liouying, Tainan 73657, Taiwan, R.O.C., Department of Optometry, Shu‑Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan, R.O.C., Department of Pathology, Golden Hospital, Pingtung 90049, Taiwan, R.O.C., Department of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan, R.O.C., Department of Anatomy, School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, R.O.C., Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, R.O.C.
    Copyright: © Lan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 705
    |
    Published online on: August 3, 2021
       https://doi.org/10.3892/ol.2021.12966
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Abstract

It has been reported that paclitaxel activates cell cycle arrest and increases caspase protein expression to induce apoptosis in head and neck squamous cell carcinoma (HNSCC) cell lines. However, the potential signaling pathway regulating this apoptotic phenomenon remains unclear. The present study used OEC‑M1 cells to investigate the underlying molecular mechanism of paclitaxel‑induced apoptosis. Following treatment with paclitaxel, cell viability was assessed via the MTT assay. Necrosis, apoptosis, cell cycle and mitochondrial membrane potential (∆Ψm) were analyzed via flow cytometric analyses, respectively. Western blot analysis was performed to detect the expression levels of proteins associated with the MAPK and caspase signaling pathways. The results demonstrated that low‑dose paclitaxel (50 nM) induced apoptosis but not necrosis in HNSCC cells. In addition, paclitaxel activated the c‑Jun N‑terminal kinase (JNK), but not extracellular signal‑regulated kinase or p38 mitogen‑activated protein kinase. The paclitaxel‑activated JNK contributed to paclitaxel‑induced apoptosis, activation of caspase‑3, ‑6, ‑7, ‑8 and ‑9, and reduction of ∆Ψm. In addition, caspase‑8 and ‑9 inhibitors, respectively, significantly decreased paclitaxel‑induced apoptosis. Notably, Bid was truncated following treatment with paclitaxel. Taken together, the results of the present study suggest that paclitaxel‑activated JNK is required for caspase activation and loss of ∆Ψm, which results in apoptosis of HNSCC cells. These results may provide mechanistic basis for designing more effective paclitaxel‑combining regimens to treat HNSCC.
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1 

Rades D, Seidl D, Wollenberg B, Schild SE and Hakim SG: Radiochemotherapy with paclitaxel for recurrent previously irradiated squamous cell carcinoma of the head and neck. Anticancer Res. 36:5463–5468. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, et al: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 349:2091–2098. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Psyrri A, Kwong M, DiStasio S, Lekakis L, Kassar M, Sasaki C, Wilson LD, Haffty BG, Son YH, Ross DA, et al: Cisplatin, fluorouracil, and leucovorin induction chemotherapy followed by concurrent cisplatin chemoradiotherapy for organ preservation and cure in patients with advanced head and neck cancer: Long-term follow-up. J Clin Oncol. 22:3061–3069. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Lo Nigro C, Denaro N, Merlotti A and Merlano M: Head and neck cancer: Improving outcomes with a multidisciplinary approach. Cancer Manag Res. 9:363–371. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Adamo V, Ferraro G, Pergolizzi S, Sergi C, Laudani A, Settineri N, Alafaci E, Scimone A, Spano F and Spitaleri G: Paclitaxel and cisplatin in patients with recurrent and metastatic head and neck squamous cell carcinoma. Oral Oncol. 40:525–531. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Monnerat C, Faivre S, Temam S, Bourhis J and Raymond E: End points for new agents in induction chemotherapy for locally advanced head and neck cancers. Ann Oncol. 13:995–1006. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Pignon JP, Bourhis J, Domenge C and Designe L: Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer. Lancet. 355:949–955. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Pendleton KP and Grandis JR: Cisplatin-based chemotherapy options for recurrent and/or metastatic squamous cell cancer of the head and neck. Clin Med Insights Ther. 2013.10.4137/CMT.S10409, 2013. View Article : Google Scholar : PubMed/NCBI

9 

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Rowinsky EK and Donehower RC: Paclitaxel (taxol). N Engl J Med. 332:1004–1014. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Abu Samaan TM, Samec M, Liskova A, Kubatka P and Busselberg D: Paclitaxel's mechanistic and clinical effects on breast cancer. Biomolecules. 9:7892019. View Article : Google Scholar : PubMed/NCBI

12 

Habib S, Delourme J, Dhalluin X, Petyt G, Tacelli N, Scherpereel A, Lafitte JJ and Cortot AB: Bevacizumab and weekly paclitaxel for non-squamous non small cell lung cancer patients: A retrospective study. Lung Cancer. 80:197–202. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Specenier P and Vermorken JB: The role of taxanes and targeted therapies in locally advanced head and neck cancer. Curr Opin Oncol. 19:195–201. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Ferrari D, Ghi MG, Franzese C, Codeca C, Gau M and Fayette J: The slippery role of induction chemotherapy in head and neck cancer: Myth and reality. Front Oncol. 10:72020. View Article : Google Scholar : PubMed/NCBI

15 

Xiao P, Ma T, Zhou C, Xu Y, Liu Y and Zhang H: Anticancer effect of docetaxel induces apoptosis of prostate cancer via the cofilin-1 and paxillin signaling pathway. Mol Med Rep. 13:4079–4084. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Miller AV, Hicks MA, Nakajima W, Richardson AC, Windle JJ and Harada H: Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor. PLoS One. 8:e606852013. View Article : Google Scholar : PubMed/NCBI

17 

Han TD, Shang DH and Tian Y: Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma. Genet Mol Res. 15:2016. View Article : Google Scholar

18 

Pan Z, Avila A and Gollahon L: Paclitaxel induces apoptosis in breast cancer cells through different calcium-regulating mechanisms depending on external calcium conditions. Int J Mol Sci. 15:2672–2694. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Hu J, Zhang NA, Wang R, Huang F and Li G: Paclitaxel induces apoptosis and reduces proliferation by targeting epidermal growth factor receptor signaling pathway in oral cavity squamous cell carcinoma. Oncol Lett. 10:2378–2384. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Nonaka M, Ikeda H, Fujisawa A, Uehara M and Inokuchi T: Induction of apoptosis by paclitaxel in human oral carcinoma cells. Int J Oral Maxillofac Surg. 35:649–652. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Holsinger FC, Doan DD, Jasser SA, Swan EA, Greenberg JS, Schiff BA, Bekele BN, Younes MN, Bucana CD, Fidler IJ and Myers JN: Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer. Clin Cancer Res. 9:3183–3189. 2003.PubMed/NCBI

22 

Ganansia-Leymarie V, Bischoff P, Bergerat JP and Holl V: Signal transduction pathways of taxanes-induced apoptosis. Curr Med Chem Anticancer Agents. 3:291–306. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Huang CY, Ju DT, Chang CF, Muralidhar Reddy P and Velmurugan BK: A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei). 7:232017. View Article : Google Scholar : PubMed/NCBI

24 

Hsiao JR, Leu SF and Huang BM: Apoptotic mechanism of paclitaxel-induced cell death in human head and neck tumor cell lines. J Oral Pathol Med. 38:188–197. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Cargnello M and Roux PP: Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 75:50–83. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Wang X, Martindale JL and Holbrook NJ: Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 275:39435–39443. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Teraishi F, Zhang L, Guo W, Dong F, Davis JJ, Lin A and Fang B: Activation of c-Jun NH2-terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells. FEBS Lett. 579:6681–6687. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Uzu M, Sato H, Shimizu A, Shibata Y, Ueno K and Hisaka A: Connexin 43 enhances Bax activation via JNK activation in sunitinib-induced apoptosis in mesothelioma cells. J Pharmacol Sci. 134:101–107. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Schrantz N, Bourgeade MF, Mouhamad S, Leca G, Sharma S and Vazquez A: p38-mediated regulation of an Fas-associated death domain protein-independent pathway leading to caspase-8 activation during TGFbeta-induced apoptosis in human Burkitt lymphoma B cells BL41. Mol Biol Cell. 12:3139–3151. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C and Yin T: ROS/KRAS/AMPK signaling contributes to gemcitabine-induced stem-like cell properties in pancreatic cancer. Mol Ther Oncolytics. 14:299–312. 2019. View Article : Google Scholar : PubMed/NCBI

31 

James D, Parone PA, Terradillos O, Lucken-Ardjomande S, Montessuit S and Martinou JC: Mechanisms of mitochondrial outer membrane permeabilization. Novartis Found Symp. 287:170–176; discussion 176-182. 2007.PubMed/NCBI

32 

Gahl RF, Dwivedi P and Tjandra N: Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis. Cell Death Dis. 7:e24242016. View Article : Google Scholar : PubMed/NCBI

33 

Tait SW and Green DR: Mitochondrial regulation of cell death. Cold Spring Harb Perspect Biol. 5:a0087062013. View Article : Google Scholar : PubMed/NCBI

34 

Li P, Zhou L, Zhao T, Liu X, Zhang P, Liu Y, Zheng X and Li Q: Caspase-9: Structure, mechanisms and clinical application. Oncotarget. 8:23996–24008. 2017. View Article : Google Scholar : PubMed/NCBI

35 

McIlwain DR, Berger T and Mak TW: Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 7:a0267162015. View Article : Google Scholar : PubMed/NCBI

36 

Foo NP, Ko CL, Chu CY, Wang CY, So EC and Huang BM: Arsenic compounds activate the MAPK and caspase pathways to induce apoptosis in OEC-M1 gingival epidermal carcinoma. Oncol Rep. 44:2701–2714. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Krysko DV, Vanden Berghe T, D'Herde K and Vandenabeele P: Apoptosis and necrosis: Detection, discrimination and phagocytosis. Methods. 44:205–221. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 139:271–279. 1991. View Article : Google Scholar : PubMed/NCBI

39 

Galluzzi L, Zamzami N, de La Motte Rouge T, Lemaire C, Brenner C and Kroemer G: Methods for the assessment of mitochondrial membrane permeabilization in apoptosis. Apoptosis. 12:803–813. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275. 1951. View Article : Google Scholar : PubMed/NCBI

41 

Yeung TK, Germond C, Chen X and Wang Z: The mode of action of taxol: Apoptosis at low concentration and necrosis at high concentration. Biochem Biophys Res Commun. 263:398–404. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Esteve MA, Carre M and Braguer D: Microtubules in apoptosis induction: Are they necessary? Curr Cancer Drug Targets. 7:713–729. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Ulukaya E, Karaagac E, Ari F, Oral AY, Adim SB, Tokullugil AH and Evrensel T: Chemotherapy increases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients. Radiol Oncol. 45:116–122. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Lu KH, Lue KH, Chou MC and Chung JG: Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). J Orthop Res. 23:988–994. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Mhaidat NM, Wang Y, Kiejda KA, Zhang XD and Hersey P: Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2. Mol Cancer Ther. 6:752–761. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Janssen K, Pohlmann S, Janicke RU, Schulze-Osthoff K and Fischer U: Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood. 110:3662–3672. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Li H, Zhu H, Xu CJ and Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94:491–501. 1998. View Article : Google Scholar : PubMed/NCBI

48 

Baig S, Seevasant I, Mohamad J, Mukheem A, Huri HZ and Kamarul T: Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand? Cell Death Dis. 7:e20582016. View Article : Google Scholar : PubMed/NCBI

49 

Huang GC, Liu SY, Lin MH, Kuo YY and Liu YC: The synergistic cytotoxicity of cisplatin and taxol in killing oral squamous cell carcinoma. Jpn J Clin Oncol. 34:499–504. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Dhuriya YK and Sharma D: Necroptosis: A regulated inflammatory mode of cell death. J Neuroinflammation. 15:1992018. View Article : Google Scholar : PubMed/NCBI

51 

Lee SY, Ju MK, Jeon HM, Jeong EK, Lee YJ, Kim CH, Park HG, Han SI and Kang HS: Regulation of tumor progression by programmed necrosis. Oxid Med Cell Longev. 2018:35374712018. View Article : Google Scholar : PubMed/NCBI

52 

Mielke S: Individualized pharmacotherapy with paclitaxel. Curr Opin Oncol. 19:586–589. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Eniu A, Palmieri FM and Perez EA: Weekly administration of docetaxel and paclitaxel in metastatic or advanced breast cancer. Oncologist. 10:665–685. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Stone AA and Chambers TC: Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells. Exp Cell Res. 254:110–119. 2000. View Article : Google Scholar : PubMed/NCBI

55 

Park SJ, Wu CH, Gordon JD, Zhong X, Emami A and Safa AR: Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 279:51057–51067. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Broker LE, Kruyt FA and Giaccone G: Cell death independent of caspases: A review. Clin Cancer Res. 11:3155–3162. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Constantinou C, Papas KA and Constantinou AI: Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy? Curr Cancer Drug Targets. 9:717–728. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Qu L, Liu FX, Cao XC, Xiao Q, Yang X and Ren KQ: Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells. Exp Ther Med. 8:1494–1500. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Brockmann A, Bluwstein A, Kogel A, May S, Marx A, Tschan MP and Brunner T: Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation. Cell Death Dis. 6:e17782015. View Article : Google Scholar : PubMed/NCBI

60 

Alexandre J, Batteux F, Nicco C, Chéreau C, Laurent A, Guillevin L, Weill B and Goldwasser F: Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer. 119:41–48. 2006. View Article : Google Scholar : PubMed/NCBI

61 

Taniguchi T, Takahashi M, Shinohara F, Sato T, Echigo S and Rikiishi H: Involvement of NF-kappaB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma. Int J Mol Med. 15:667–673. 2005.PubMed/NCBI

62 

Zhao Q, Liu Y, Zhong J, Bi Y, Liu Y, Ren Z, Li X, Jia J, Yu M and Yu X: Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo. Cell Death Discov. 5:1252019. View Article : Google Scholar : PubMed/NCBI

63 

Asakuma J, Sumitomo M, Asano T, Asano T and Hayakawa M: Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel. Cancer Res. 63:1365–1370. 2003.PubMed/NCBI

64 

Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, et al: Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell. 11:498–512. 2007. View Article : Google Scholar : PubMed/NCBI

65 

Lu S, Natarajan SK, Mott JL, Kharbanda KK and Harrison-Findik DD: Ceramide induces human hepcidin gene transcription through JAK/STAT3 pathway. PLoS One. 11:e01474742016. View Article : Google Scholar : PubMed/NCBI

66 

Villena J, Henriquez M, Torres V, Moraga F, Díaz-Elizondo J, Arredondo C, Chiong M, Olea-Azar C, Stutzin A, Lavandero S and Quest AF: Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells. Free Radic Biol Med. 44:1146–1160. 2008. View Article : Google Scholar : PubMed/NCBI

67 

Kogot-Levin A and Saada A: Ceramide and the mitochondrial respiratory chain. Biochimie. 100:88–94. 2014. View Article : Google Scholar : PubMed/NCBI

68 

Yamaguchi H, Chen J, Bhalla K and Wang HG: Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. J Biol Chem. 279:39431–39437. 2004. View Article : Google Scholar : PubMed/NCBI

69 

Lee WT and Chang CW: Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis. Mol Cell Biochem. 343:271–279. 2010. View Article : Google Scholar : PubMed/NCBI

70 

Henry RE, Andrysik Z, Paris R, Galbraith MD and Espinosa JM: A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. EMBO J. 31:1266–1278. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Shen YH, Utama B, Wang J, Raveendran M, Senthil D, Waldman WJ, Belcher JD, Vercellotti G, Martin D, Mitchelle BM and Wang XL: Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways. Circ Res. 94:1310–1317. 2004. View Article : Google Scholar : PubMed/NCBI

72 

Aubrey BJ, Kelly GL, Janic A, Herold MJ and Strasser A: How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 25:104–113. 2018. View Article : Google Scholar : PubMed/NCBI

73 

Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, et al: Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol. 21:2743–2754. 2001. View Article : Google Scholar : PubMed/NCBI

74 

Dong Y, Shen X, He M, Wu Z, Zheng Q, Wang Y, Chen Y, Wu S, Cui J and Zeng Z: Activation of the JNK-c-Jun pathway in response to irradiation facilitates Fas ligand secretion in hepatoma cells and increases hepatocyte injury. J Exp Clin Cancer Res. 35:1142016. View Article : Google Scholar : PubMed/NCBI

75 

Chu R, Upreti M, Ding WX, Yin XM and Chambers TC: Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochem Pharmacol. 78:241–248. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lan Y, Chen Y, Liu C, Tung K, Wu Y, Lin S, Wu C, Chang H, Chen Y, Huang B, Huang B, et al: Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma. Oncol Lett 22: 705, 2021.
APA
Lan, Y., Chen, Y., Liu, C., Tung, K., Wu, Y., Lin, S. ... Huang, B. (2021). Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma. Oncology Letters, 22, 705. https://doi.org/10.3892/ol.2021.12966
MLA
Lan, Y., Chen, Y., Liu, C., Tung, K., Wu, Y., Lin, S., Wu, C., Chang, H., Chen, Y., Huang, B."Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma". Oncology Letters 22.4 (2021): 705.
Chicago
Lan, Y., Chen, Y., Liu, C., Tung, K., Wu, Y., Lin, S., Wu, C., Chang, H., Chen, Y., Huang, B."Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma". Oncology Letters 22, no. 4 (2021): 705. https://doi.org/10.3892/ol.2021.12966
Copy and paste a formatted citation
x
Spandidos Publications style
Lan Y, Chen Y, Liu C, Tung K, Wu Y, Lin S, Wu C, Chang H, Chen Y, Huang B, Huang B, et al: Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma. Oncol Lett 22: 705, 2021.
APA
Lan, Y., Chen, Y., Liu, C., Tung, K., Wu, Y., Lin, S. ... Huang, B. (2021). Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma. Oncology Letters, 22, 705. https://doi.org/10.3892/ol.2021.12966
MLA
Lan, Y., Chen, Y., Liu, C., Tung, K., Wu, Y., Lin, S., Wu, C., Chang, H., Chen, Y., Huang, B."Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma". Oncology Letters 22.4 (2021): 705.
Chicago
Lan, Y., Chen, Y., Liu, C., Tung, K., Wu, Y., Lin, S., Wu, C., Chang, H., Chen, Y., Huang, B."Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma". Oncology Letters 22, no. 4 (2021): 705. https://doi.org/10.3892/ol.2021.12966
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