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Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma

  • Authors:
    • Yuyang Tian
    • Li Wang
    • Yanming Zhang
    • Lianqiao Li
    • Yingying Fei
    • Xingxia Zhang
    • Guoqiang Lin
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Hainan Cancer Hospital, Haikou, Hainan 571000, P.R. China, Department of Hematology, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, P.R. China, Department of Radiotherapy, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 709
    |
    Published online on: August 5, 2021
       https://doi.org/10.3892/ol.2021.12970
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Abstract

To the best of our knowledge, the effect of miR‑212‑3p on sex‑determining region Y‑box 11 (SOX11) expression has not been previously investigated and how this effect affects cell proliferation and migration in lymphoma remains unclear. The present study aimed to assess the association between microRNA‑212‑3p (miR‑212‑3p) and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma. Cancer tissue and corresponding paracancerous tissue samples were collected from 65 patients with mantle cell lymphoma. The mRNA expression levels of miR‑212‑3p and SOX11 were analyzed using quantitative PCR, and SOX11 protein expression was determined using western blotting. Following transfection, the miR‑212‑3p mimic group exhibited a significantly lower SOX11 mRNA and protein expression than the miR‑NC group. After 48‑72 h of transfection, cell proliferation in the miR‑212‑3p mimic group was significantly lower than that in the miR‑NC group. Furthermore, the miR‑212‑3p mimic group exhibited significantly lower cell invasion and significantly higher apoptosis than the miR‑NC group. The current results suggested that miR‑212‑3p inhibited lymphoma cell proliferation and migration, and promoted their apoptosis by specifically regulating SOX11. Therefore, miR‑212‑3p may serve as a novel therapeutic target and marker for lymphoma.
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Copy and paste a formatted citation
Spandidos Publications style
Tian Y, Wang L, Zhang Y, Li L, Fei Y, Zhang X and Lin G: Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma. Oncol Lett 22: 709, 2021.
APA
Tian, Y., Wang, L., Zhang, Y., Li, L., Fei, Y., Zhang, X., & Lin, G. (2021). Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma. Oncology Letters, 22, 709. https://doi.org/10.3892/ol.2021.12970
MLA
Tian, Y., Wang, L., Zhang, Y., Li, L., Fei, Y., Zhang, X., Lin, G."Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma". Oncology Letters 22.4 (2021): 709.
Chicago
Tian, Y., Wang, L., Zhang, Y., Li, L., Fei, Y., Zhang, X., Lin, G."Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma". Oncology Letters 22, no. 4 (2021): 709. https://doi.org/10.3892/ol.2021.12970
Copy and paste a formatted citation
x
Spandidos Publications style
Tian Y, Wang L, Zhang Y, Li L, Fei Y, Zhang X and Lin G: Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma. Oncol Lett 22: 709, 2021.
APA
Tian, Y., Wang, L., Zhang, Y., Li, L., Fei, Y., Zhang, X., & Lin, G. (2021). Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma. Oncology Letters, 22, 709. https://doi.org/10.3892/ol.2021.12970
MLA
Tian, Y., Wang, L., Zhang, Y., Li, L., Fei, Y., Zhang, X., Lin, G."Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma". Oncology Letters 22.4 (2021): 709.
Chicago
Tian, Y., Wang, L., Zhang, Y., Li, L., Fei, Y., Zhang, X., Lin, G."Association between miR‑212‑3p and SOX11, and the effects of miR‑212‑3p on cell proliferation and migration in mantle cell lymphoma". Oncology Letters 22, no. 4 (2021): 709. https://doi.org/10.3892/ol.2021.12970
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