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Identification of GNA12‑driven gene signatures and key signaling networks in ovarian cancer

  • Authors:
    • Ji-Hee Ha
    • Muralidharan Jayaraman
    • Mingda Yan
    • Padmaja Dhanasekaran
    • Ciro Isidoro
    • Yong-Sang Song
    • Danny N. Dhanasekaran
  • View Affiliations / Copyright

    Affiliations: Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA, Laboratory of Molecular Pathology and NanoBioImaging, Department of Health Sciences, University of Eastern Piedmont, I‑17‑28100 Novara, Italy, Department of Obstetrics and Gynecology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul 151‑921, Republic of Korea
    Copyright: © Ha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 719
    |
    Published online on: August 10, 2021
       https://doi.org/10.3892/ol.2021.12980
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Abstract

With the focus on defining the oncogenic network stimulated by lysophosphatidic acid (LPA) in ovarian cancer, the present study sought to interrogate the oncotranscriptome regulated by the LPA‑mediated signaling pathway. LPA, LPA‑receptor (LPAR) and LPAR‑activated G protein 12 α‑subunit, encoded by G protein subunit α 12 (GNA12), all serve an important role in ovarian cancer progression. While the general signaling mechanism regulated by LPA/LPAR/GNA12 has previously been characterized, the global transcriptomic network regulated by GNA12 in ovarian cancer pathophysiology remains largely unknown. To define the LPA/LPAR/GNA12‑orchestrated oncogenic networks in ovarian cancer, transcriptomic and bioinformatical analyses were conducted using SKOV3 cells, in which the expression of GNA12 was silenced. Array analysis was performed in Agilent SurePrint G3 Human Comparative Genomic Hybridization 8x60 microarray platform. The array results were validated using Kuramochi cells. Gene and functional enrichment analyses were performed using Database for Annotation, Visualization and Integrated Discovery, Search Tool for Retrieval of Interacting Genes and Cytoscape algorithms. The results indicated a paradigm in which GNA12 drove ovarian cancer progression by upregulating a pro‑tumorigenic network with AKT1, VEGFA, TGFB1, BCL2L1, STAT3, insulin‑like growth factor 1 and growth hormone releasing hormone as critical hub and/or bottleneck nodes. Moreover, GNA12 downregulated a growth‑suppressive network involving proteasome 20S subunit (PSM) β6, PSM α6, PSM ATPase 5, ubiquitin conjugating enzyme E2 E1, PSM non‑ATPase 10, NDUFA4 mitochondrial complex‑associated, NADH:ubiquinone oxidoreductase subunit B8 and anaphase promoting complex subunit 1 as hub or bottleneck nodes. In addition to providing novel insights into the LPA/LPAR/GNA12‑regulated oncogenic networks in ovarian cancer, the present study identified several potential nodes in this network that could be assessed for targeted therapy.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer Statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Bast RC Jr, Lu Z, Han CY, Lu KH, Anderson KS, Drescher CW and Skates SJ: Biomarkers and strategies for early detection of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 29:2504–2512. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Wang Q, Peng H, Qi X, Wu M and Zhao X: Targeted therapies in gynecological cancers: A comprehensive review of clinical evidence. Signal Transduct Target Ther. 5:1372020. View Article : Google Scholar : PubMed/NCBI

5 

Mills GB and Moolenaar WH: The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer. 3:582–591. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Cui R, Bai H, Cao G and Zhang Z: The role of lysophosphatidic acid receptors in ovarian cancer: A minireview. Crit Rev Eukaryot Gene Expr. 30:265–272. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Moolenaar WH: LPA: A novel lipid mediator with diverse biological actions. Trends Cell Biol. 4:213–219. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Moolenaar WH, van Meeteren LA and Giepmans BN: The ins and outs of lysophosphatidic acid signaling. Bioessays. 26:870–881. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Noguchi K, Herr D, Mutoh T and Chun J: Lysophosphatidic acid (LPA) and its receptors. Curr Opin Pharmacol. 9:15–23. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Radhika V and Dhanasekaran N: Transforming G proteins. Oncogene. 20:1607–1614. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Goldsmith ZG and Dhanasekaran DN: G protein regulation of MAPK networks. Oncogene. 26:3122–3142. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Radhakrishnan R, Ha JH and Dhanasekaran DN: Mitogenic signaling by the gep oncogene involves the upregulation of S-phase kinase-associated protein 2. Genes Cancer. 1:1033–1043. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ha JH, Radhakrishnan R, Jayaraman M, Yan M, Ward JD, Fung KM, Moxley K, Sood AK, Isidoro C, Mukherjee P, et al: LPA induces metabolic reprogramming in ovarian cancer via a pseudohypoxic response. Cancer Res. 78:1923–1934. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Radhakrishnan R, Ha JH, Jayaraman M, Liu J, Moxley KM, Isidoro C, Sood AK, Song YS and Dhanasekaran DN: Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts. Cancer Lett. 442:464–474. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Goldsmith ZG, Ha JH, Jayaraman M and Dhanasekaran DN: Lysophosphatidic acid stimulates the proliferation of ovarian cancer cells via the gep proto-oncogene Galpha(12). Genes Cancer. 2:563–575. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R and Dhanasekaran DN: Determinant role for the gep oncogenes, Galpha12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 6:356–364. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Juneja J and Casey PJ: Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol. 158:32–40. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y and Casey PJ: A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem. 281:26483–24490. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y, Dewhirst MW, Fields TA and Casey PJ: The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci USA. 103:8173–8178. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Liu SC, Jen YM, Jiang SS, Chang JL, Hsiung CA, Wang CH and Juang JL: G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Res. 69:6122–6130. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Wuchty S, Zhang A, Walling J, Ahn S, Li A, Quezado M, Oberholtzer C, Zenklusen JC and Fine HA: Gene pathways and subnetworks distinguish between major glioma subtypes and elucidate potential underlying biology. J Biomed Inform. 43:945–952. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID Bioinformatics Resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35:W169–W175. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI

26 

Liu Z, Meng J, Li X, Zhu F, Liu T, Wu G and Zhang L: Identification of hub genes and key pathways associated with two subtypes of diffuse large B-cell lymphoma based on gene expression profiling via integrated bioinformatics. Biomed Res Int. 2018:35745342018.PubMed/NCBI

27 

Vogler O, Barcelo JM, Ribas C and Escriba PV: Membrane interactions of G proteins and other related proteins. Biochim Biophys Acta. 1778:1640–10652. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Solary E, Eymin B, Droin N and Haugg M: Proteases, proteolysis, and apoptosis. Cell Biol Toxicol. 14:121–132. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Yu H, Kim PM, Sprecher E, Trifonov V and Gerstein M: The importance of bottlenecks in protein networks: Correlation with gene essentiality and expression dynamics. PLoS Comput Biol. 3:e592007. View Article : Google Scholar : PubMed/NCBI

30 

Charitou T, Bryan K and Lynn DJ: Using biological networks to integrate, visualize and analyze genomics data. Genet Sel Evol. 48:272016. View Article : Google Scholar : PubMed/NCBI

31 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

33 

Despierre E, Lambrechts D, Neven P, Amant F, Lambrechts S and Vergote I: The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment. Gynecol Oncol. 117:358–365. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Guan J, Darb-Esfahani S, Richter R, Taube ET, Ruscito I, Mahner S, Woelber L, Prieske K, Concin N, Vergote I, et al: Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): A study from the Tumor Bank Ovarian Cancer (TOC) Consortium. J Cancer Res Clin Oncol. 145:1063–1073. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Sopo M, Anttila M, Hamalainen K, Kivela A, Yla-Herttuala S, Kosma VM, Keski-Nisula L and Sallinen H: Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer. BMC Cancer. 19:5842019. View Article : Google Scholar : PubMed/NCBI

36 

Li X, Hu Z, Shi H, Wang C, Lei J and Cheng Y: Inhibition of VEGFA increases the sensitivity of ovarian cancer cells to chemotherapy by suppressing VEGFA-Mediated Autophagy. Onco Targets Ther. 13:8161–8171. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Bai Y, Li LD, Li J, Chen RF, Yu HL, Sun HF, Wang JY and Lu X: A FXYD5/TGFβ/SMAD positive feedback loop drives epithelialtomesenchymal transition and promotes tumor growth and metastasis in ovarian cancer. Int J Oncol. 56:301–314. 2020.PubMed/NCBI

38 

Liang S, Yao Q, Wei D, Liu M, Geng F, Wang Q and Wang YS: KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor-β1 expression. J Cell Biochem. 120:493–506. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Beale PJ, Rogers P, Boxall F, Sharp SY and Kelland LR: BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma. Br J Cancer. 82:436–440. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Yuan J, Lan H, Jiang X, Zeng D and Xiao S: Bcl2 family: Novel insight into individualized therapy for ovarian cancer (Review). Int J Mol Med. 46:1255–1265. 2020.PubMed/NCBI

41 

Liang R, Chen X, Chen L, Wan F, Chen K, Sun Y and Zhu X: STAT3 signaling in ovarian cancer: A potential therapeutic target. J Cancer. 11:837–848. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Diener A and Rohrmann S: Associations of serum carotenoid concentrations and fruit or vegetable consumption with serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 concentrations in the Third National Health and Nutrition Examination survey (NHANES III). J Nutr Sci. 5:e132016. View Article : Google Scholar : PubMed/NCBI

43 

Yahya MA, Sharon SM, Hantisteanu S, Hallak M and Bruchim I: The role of the insulin-like growth factor 1 pathway in immune tumor microenvironment and its clinical ramifications in gynecologic malignancies. Front Endocrinol (Lausanne). 9:2972018. View Article : Google Scholar : PubMed/NCBI

44 

Khorram O, Garthwaite M, Grosen E and Golos T: Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions. Fertil Steril. 75:174–179. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Klukovits A, Schally AV, Szalontay L, Vidaurre I, Papadia A, Zarandi M, Varga JL, Block NL and Halmos G: Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers. Cancer. 118:670–680. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Wheaton K, Sarkari F, Stanly Johns B, Davarinejad H, Egorova O, Kaustov L, Raught B, Saridakis V and Sheng Y: UbE2E1/UBCH6 is a critical in vivo E2 for the PRC1-catalyzed ubiquitination of H2A at lys-119. J Biol Chem. 292:2893–2902. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Sohn D, Totzke G, Schulze-Osthoff K and Janicke RU: Friend or foe? The proteasome in combined cancer therapy. Cell Cycle. 5:841–845. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Sohn D, Totzke G, Essmann F, Schulze-Osthoff K, Levkau B and Janicke RU: The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol Cell Biol. 26:1967–1978. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Milone MR, Pucci B, Bifulco K, Iannelli F, Lombardi R, Ciardiello C, Bruzzese F, Carriero MV and Budillon A: Proteomic analysis of zoledronic-acid resistant prostate cancer cells unveils novel pathways characterizing an invasive phenotype. Oncotarget. 6:5324–5341. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Yim JH, Yun HS, Lee SJ, Baek JH, Lee CW, Song JY, Um HD, Park JK, Kim JS, Park IC and Hwang SG: Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells. Biochem Biophys Res Commun. 469:94–100. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, et al: Wild-type p53 promotes cancer metabolic switch by inducing PUMA-dependent suppression of oxidative phosphorylation. Cancer Cell. 35:191–203 e8. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Ajeawung NF, Nguyen TTM, Lu L, Kucharski TJ, Rousseau J, Molidperee S, Atienza J, Gamache I, Jin W, Plon SE, et al: Mutations in ANAPC1, encoding a scaffold subunit of the anaphase-promoting complex, cause rothmund-thomson syndrome type 1. Am J Hum Genet. 105:625–630. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Ping Z, Lim R, Bashir T, Pagano M and Guardavaccaro D: APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit. Cell Cycle. 11:1999–2005. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Kernan J, Bonacci T and Emanuele MJ: Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle. Biochim Biophys Acta Mol Cell Res. 1865:1924–1933. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Wu Y, Xia L, Guo Q, Zhu J, Deng Y and Wu X: Identification of chemoresistance-associated key genes and pathways in high-grade serous ovarian cancer by bioinformatics analyses. Cancer Manag Res. 12:5213–5223. 2020. View Article : Google Scholar : PubMed/NCBI

56 

Chen L, Zhang J, Li H, Niu J, Xue H, Liu B, Wang Q, Luo X, Zhang F, Zhao D and Cao S: Transcriptomic analysis reveals candidate genes for female sterility in pomegranate flowers. Front Plant Sci. 8:14302017. View Article : Google Scholar : PubMed/NCBI

57 

Hou DL, Chen L, Liu B, Song LN and Fang T: Identification of common gene networks responsive to radiotherapy in human cancer cells. Cancer Gene Ther. 21:542–548. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Lei Y, Henderson BR, Emmanuel C, Harnett PR and deFazio A: Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncogene. 34:485–495. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Takahashi A, Seike M, Chiba M, Takahashi S, Nakamichi S, Matsumoto M, Takeuchi S, Minegishi Y, Noro R, Kunugi S, et al: Ankyrin repeat domain 1 overexpression is associated with common resistance to afatinib and osimertinib in EGFR-mutant lung cancer. Sci Rep. 8:148962018. View Article : Google Scholar : PubMed/NCBI

60 

Morone S, Lo-Buono N, Parrotta R, Giacomino A, Nacci G, Brusco A, Larionov A, Ostano P, Mello-Grand M, Chiorino G, et al: Overexpression of CD157 contributes to epithelial ovarian cancer progression by promoting mesenchymal differentiation. PLoS One. 7:e436492012. View Article : Google Scholar : PubMed/NCBI

61 

Shim E, Shim H, Bae J, Lee H and Jeoung D: CAGE displays oncogenic potential and induces cytolytic T lymphocyte activity. Biotechnol Lett. 28:515–522. 2006. View Article : Google Scholar : PubMed/NCBI

62 

Janecki DM, Sajek M, Smialek MJ, Kotecki M, Ginter-Matuszewska B, Kuczynska B, Spik A, Kolanowski T, Kitazawa R, Kurpisz M and Jaruzelska J: SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma. Oncotarget. 9:32466–32477. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Satyavarapu EM, Nath S and Mandal C: Desialylation of Atg5 by sialidase (Neu2) enhances autophagosome formation to induce anchorage-dependent cell death in ovarian cancer cells. Cell Death Discov. 7:262021. View Article : Google Scholar : PubMed/NCBI

64 

Ehrenreich H, Hasselblatt M, Knerlich F, von Ahsen N, Jacob S, Sperling S, Woldt H, Vehmeyer K, Nave KA and Sirén AL: A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci USA. 102:862–867. 2005. View Article : Google Scholar : PubMed/NCBI

65 

Puls KL, Ni J, Liu D, Morahan G and Wright MD: The molecular characterisation of a novel tetraspanin protein, TM4-B(1). Biochim Biophys Acta. 1447:93–99. 1999. View Article : Google Scholar : PubMed/NCBI

66 

Lascorz J, Chen B, Hemminki K and Forsti A: Consensus pathways implicated in prognosis of colorectal cancer identified through systematic enrichment analysis of gene expression profiling studies. PLoS One. 6:e188672011. View Article : Google Scholar : PubMed/NCBI

67 

Chang IW, Liu KW, Ragunanan M, He HL, Shiue YL and Yu SC: SERPINB5 expression: Association with CCRT response and prognostic value in rectal cancer. Int J Med Sci. 15:376–84. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Zhang Y, Cao L, Nguyen D and Lu H: TP53 mutations in epithelial ovarian cancer. Transl Cancer Res. 5:650–663. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Ren YA, Mullany LK, Liu Z, Herron AJ, Wong KK and Richards JS: Mutant p53 promotes epithelial ovarian cancer by regulating tumor differentiation, metastasis, and responsiveness to steroid hormones. Cancer Res. 76:2206–2218. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN and Testa JR: AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA. 89:9267–9271. 1992. View Article : Google Scholar : PubMed/NCBI

71 

Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK and Testa JR: AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. 23:5853–5857. 2004. View Article : Google Scholar : PubMed/NCBI

72 

Ghoneum A and Said N: PI3K-AKT-mTOR and NFkappaB pathways in ovarian cancer: Implications for targeted therapeutics. Cancers (Basel). 11:9492019. View Article : Google Scholar : PubMed/NCBI

73 

Masoumi Moghaddam S, Amini A, Morris DL and Pourgholami MH: Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer. Cancer Metastasis Rev. 31:143–162. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Yin X, Wang X, Shen B, Jing Y, Li Q, Cai MC, Gu Z, Yang Q, Zhang Z, Liu J, et al: A VEGF-dependent gene signature enriched in mesenchymal ovarian cancer predicts patient prognosis. Sci Rep. 6:310792016. View Article : Google Scholar : PubMed/NCBI

75 

Glaysher S, Bolton LM, Johnson P, Atkey N, Dyson M, Torrance C and Cree IA: Targeting EGFR and PI3K pathways in ovarian cancer. Br J Cancer. 109:1786–1794. 2013. View Article : Google Scholar : PubMed/NCBI

76 

Wilken JA, Badri T, Cross S, Raji R, Santin AD, Schwartz P, Branscum AJ, Baron AT, Sakhitab AI and Maihle NJ: EGFR/HER-targeted therapeutics in ovarian cancer. Future Med Chem. 4:447–469. 2012. View Article : Google Scholar : PubMed/NCBI

77 

Han GH, Chay DB, Nam S, Cho H, Chung JY and Kim JH: Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer. BMC Cancer. 19:12022019. View Article : Google Scholar : PubMed/NCBI

78 

Cai J, Xu L, Tang H, Yang Q, Yi X, Fang Y, Zhu Y and Wang Z: The role of the PTEN/PI3K/Akt pathway on prognosis in epithelial ovarian cancer: A meta-analysis. Oncologist. 19:528–335. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Duncan TJ, Al-Attar A, Rolland P, Scott IV, Deen S, Liu DT, Spendlove I and Durrant LG: Vascular endothelial growth factor expression in ovarian cancer: A model for targeted use of novel therapies? Clin Cancer Res. 14:3030–3035. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Hu Q, Hisamatsu T, Haemmerle M, Cho MS, Pradeep S, Rupaimoole R, Rodriguez-Aguayo C, Lopez-Berestein G, Wong STC, Sood AK and Afshar-Kharghan V: Role of platelet-derived Tgfβ1 in the progression of ovarian cancer. Clin Cancer Res. 23:5611–5621. 2017. View Article : Google Scholar : PubMed/NCBI

81 

Bruchim I and Werner H: Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opin Ther Targets. 17:307–320. 2013. View Article : Google Scholar : PubMed/NCBI

82 

Kahan Z, Arencibia JM, Csernus VJ, Groot K, Kineman RD, Robinson WR and Schally AV: Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers. J Clin Endocrinol Metab. 84:582–589. 1999. View Article : Google Scholar : PubMed/NCBI

83 

Yokoyama T, Kohn EC, Brill E and Lee JM: Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 50:1064–1074. 2017. View Article : Google Scholar : PubMed/NCBI

84 

Wang H, Liu C, Cheng J, Liu J, Zhang L, He C, Shen WH, Jin H, Xu L and Zhang Y: Arabidopsis flower and embryo developmental genes are repressed in seedlings by different combinations of polycomb group proteins in association with distinct sets of cis-regulatory elements. PLoS Genet. 12:e10057712016. View Article : Google Scholar : PubMed/NCBI

85 

Diaz-Ruiz R, Rigoulet M and Devin A: The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression. Biochim Biophys Acta. 1807:568–576. 2011. View Article : Google Scholar : PubMed/NCBI

86 

Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landazuri MO and Enríquez JA: NDUFA4 is a subunit of complex IV of the mammalian electron transport chain. Cell Metab. 16:378–386. 2012. View Article : Google Scholar : PubMed/NCBI

87 

Guerrero-Castillo S, Baertling F, Kownatzki D, Wessels HJ, Arnold S, Brandt U and Nijtmans L: The assembly pathway of mitochondrial respiratory chain complex i. Cell Metab. 25:128–139. 2017. View Article : Google Scholar : PubMed/NCBI

88 

Tang JX, Thompson K, Taylor RW and Olahova M: Mitochondrial OXPHOS Biogenesis: Co-regulation of protein synthesis, import, and assembly pathways. Int J Mol Sci. 21:38202020. View Article : Google Scholar : PubMed/NCBI

89 

Deng M, Blondeau JJ, Schmidt D, Perner S, Muller SC and Ellinger J: Identification of novel differentially expressed lncRNA and mRNA transcripts in clear cell renal cell carcinoma by expression profiling. Genom Data. 5:173–175. 2015. View Article : Google Scholar : PubMed/NCBI

90 

Muller FE, Braun M, Syring I, Klumper N, Schmidt D, Perner S, Hauser S, Müller SC and Ellinger J: NDUFA4 expression in clear cell renal cell carcinoma is predictive for cancer-specific survival. Am J Cancer Res. 5:2816–2822. 2015.PubMed/NCBI

91 

Lunetti P, Di Giacomo M, Vergara D, De Domenico S, Maffia M, Zara V, Capobianco L and Ferramosca A: Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypes. FEBS J. 286:688–709. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ha J, Jayaraman M, Yan M, Dhanasekaran P, Isidoro C, Song Y and Dhanasekaran DN: Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer. Oncol Lett 22: 719, 2021.
APA
Ha, J., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y., & Dhanasekaran, D.N. (2021). Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer. Oncology Letters, 22, 719. https://doi.org/10.3892/ol.2021.12980
MLA
Ha, J., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y., Dhanasekaran, D. N."Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer". Oncology Letters 22.4 (2021): 719.
Chicago
Ha, J., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y., Dhanasekaran, D. N."Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer". Oncology Letters 22, no. 4 (2021): 719. https://doi.org/10.3892/ol.2021.12980
Copy and paste a formatted citation
x
Spandidos Publications style
Ha J, Jayaraman M, Yan M, Dhanasekaran P, Isidoro C, Song Y and Dhanasekaran DN: Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer. Oncol Lett 22: 719, 2021.
APA
Ha, J., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y., & Dhanasekaran, D.N. (2021). Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer. Oncology Letters, 22, 719. https://doi.org/10.3892/ol.2021.12980
MLA
Ha, J., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y., Dhanasekaran, D. N."Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer". Oncology Letters 22.4 (2021): 719.
Chicago
Ha, J., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y., Dhanasekaran, D. N."Identification of <em>GNA12</em>‑driven gene signatures and key signaling networks in ovarian cancer". Oncology Letters 22, no. 4 (2021): 719. https://doi.org/10.3892/ol.2021.12980
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