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Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma

  • Authors:
    • Nouha Tekiki
    • Mariko Fujita
    • Tatsuo Okui
    • Hotaka Kawai
    • May Wathone Oo
    • Toshiyuki Kawazu
    • Miki Hisatomi
    • Shunsuke Okada
    • Yohei Takeshita
    • Majd Barham
    • Hitoshi Nagatsuka
    • Yoshinobu Yanagi
    • Jun-Ichi Asaumi
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Oral Diagnosis and Dentomaxillofacial Radiology, Okayama University Hospital, Okayama 700‑8558, Japan, Department of Dental Informatics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
    Copyright: © Tekiki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 778
    |
    Published online on: September 13, 2021
       https://doi.org/10.3892/ol.2021.13039
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Abstract

Immune checkpoint inhibitors (ICIs) targeting programmed death ligand‑1 (PD‑L1) are highly promising therapies for oral squamous cell carcinoma (OSCC). The assessment of PD‑L1 expression may help predicting the therapeutic effect of ICIs and, thus, benefit patient selection. Contrast index (CI) parameters derived from dynamic contrast‑enhanced magnetic resonance imaging (DCE‑MRI) have been proven as efficient to assess microvessel density (MVD) in OSCC. The present study aimed to determine the correlation between DCE‑MRI parameters and MVD and between DCE‑MRI parameters and PD‑L1 expression to determine whether DCE‑MRI could be used non‑invasively to evaluate PD‑L1 expression in patients with OSCC. A total of 21 patients with primary OSCC who had undergone a 3T MRI scan, including DCE‑MRI, were included in the present study, and CI curve‑derived parameters were examined. The MVD and PD‑L1 expression in the surgically resected specimens were analyzed using immunohistochemistry (IHC) staining for CD31 and IHC staining for PD‑L1, respectively. The results demonstrated that the expression levels of these markers were correlated with DCE‑MRI parameters. PD‑L1 expression levels were found to be significantly correlated with the maximum CI (CI‑max; P=0.007), peak CI (CI‑peak; P=0.007), maximum CI gain (CI‑gain; P=0.006) and MVD (P=0.001) values. The mean CI‑max, CI‑peak, CI‑gain and MVD values were significantly higher in tumors with high PD‑L1 expression (P<0.05). MVD levels were also significantly correlated with the time of CI‑max (T‑max; P=0.003) and CI‑gain (P=0.037). The mean CI‑gain was significantly increased, and the mean T‑max was significantly shorter in high MVD tumors (P<0.05 and P<0.01, respectively). In summary, the findings from the present study confirmed the correlation between CI parameters, derived from DCE‑MRI, and MVD, and suggested that these parameters may be correlated with PD‑L1 expression in OSCC tumor cells.
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1 

Bauml JM, Aggarwal C and Cohen RB: Immunotherapy for head and neck cancer: Where are we now and where are we going? Ann Transl Med. 7 (Suppl 7):S752019. View Article : Google Scholar : PubMed/NCBI

2 

Twomey JD and Zhang B: Cancer immunotherapy update: FDA-approved checkpoint inhibitors and companion diagnostics. AAPS J. 23:392021. View Article : Google Scholar : PubMed/NCBI

3 

Samra B, Tam E, Baseri B and Shapira I: Checkpoint inhibitors in head and neck cancer: Current knowledge and perspectives. J Investig Med. 66:1023–1030. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, et al: The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). J Immunother Cancer. 7:1842019. View Article : Google Scholar : PubMed/NCBI

5 

Lenouvel D, González-Moles MÁ, Talbaoui A, Ramos-García P, González-Ruiz L, Ruiz-Ávila I and Gil-Montoya JA: An update of knowledge on PD-L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives. Oral Dis. 26:511–526. 2020. View Article : Google Scholar : PubMed/NCBI

6 

De Vicente JC, Rodríguez-Santamarta T, Rodrigo JP, Blanco-Lorenzo V, Allonca E and García-Pedrero JM: PD-L1 expression in tumor cells is an independent unfavorable prognostic factor in oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 28:546–554. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Forster MD and Devlin MJ: Immune checkpoint inhibition in head and neck cancer. Front Oncol. 8:3102018. View Article : Google Scholar : PubMed/NCBI

8 

McCusker MG, Orkoulas-Razis D and Mehra R: Potential of pembrolizumab in metastatic or recurrent head and neck cancer: Evidence to date. Onco Targets Ther. 13:3047–3059. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Unetsubo T, Konouchi H, Yanagi Y, Murakami J, Fujii M, Matsuzaki H, Hisatomi M, Nagatsuka H and Asaumi JI: Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density of oral squamous cell carcinomas. Oral Oncol. 45:621–626. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Pałasz P, Adamski Ł, Górska-Chrząstek M, Starzyńska A and Studniarek M: Contemporary diagnostic imaging of oral squamous cell carcinoma-A review of literature. Pol J Radiol. 82:193–202. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Koh YW, Han JH, Yoon DH, Suh C and Huh J: PD-L1 expression correlates with VEGF and microvessel density in patients with uniformly treated classical Hodgkin lymphoma. Ann Hematol. 96:1883–1890. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Szafarowski T, Sierdzinski J, Szczepanski MJ, Whiteside TL, Ludwig N and Krzeski A: Microvessel density in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 275:1845–1851. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Brierley JD, Gospodarowicz MK and Wittekind CH: TNM Classification of Malignant Tumours, 8th Edition. Oxford, UK; Hoboken, NJ: John Wiley & Sons, Inc.; 2017

14 

Takabatake K, Tsujigiwa H, Nakano K, Inada Y, Qiusheng S, Kawai H, Sukegawa S, Fushimi S and Nagatsuka H: Geometrical structure of honeycomb TCP to control dental pulp-derived cell differentiation. Materials (Basel). 13:51552020. View Article : Google Scholar : PubMed/NCBI

15 

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, et al: Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 21:425–532. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

17 

Fang L, He Y, Liu Y, Ding H, Tong Y, Hu L, Wang C, Zhang Y, Zheng X and Huang P: Adjustment of microvessel area by stromal area to improve survival prediction in non small cell lung cancer. J Cancer. 10:3397–3406. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Surov A, Meyer HJ, Gawlitza M, Höhn AK, Boehm A, Kahn T and Stumpp P: Correlations between DCE MRI and histopathological parameters in head and neck squamous cell carcinoma. Transl Oncol. 10:17–21. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Surov A, Meyer HJ, Leifels L, Höhn AK, Richter C and Winter K: Histogram analysis parameters of dynamic contrast-enhanced magnetic resonance imaging can predict histopathological findings including proliferation potential, cellularity, and nucleic areas in head and neck squamous cell carcinoma. Oncotarget. 9:21070–21077. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Jansen JFA, Carlson DL, Lu Y, Stambuk HE, Moreira AL, Singh B, Patel SG, Kraus DH, Wong RJ, Shaha AR, et al: Correlation of a priori DCE-MRI and 1H-MRS data with molecular markers in neck nodal metastases: Initial analysis. Oral Oncol. 48:717–722. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Asaumi J, Yanagi Y, Konouchi H, Hisatomi M, Matsuzaki H and Kishi K: Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck. Oral Oncol. 40:579–584. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Yanagi Y, Asaumi JI, Unetsubo T, Ashida M, Takenobu T, Hisatomi M, Matsuzaki H, Konouchi H, Katase N and Nagatsuka H: Usefulness of MRI and dynamic contrast-enhanced MRI for differential diagnosis of simple bone cysts from true cysts in the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 110:364–369. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Hisatomi M, Yanagi Y, Konouchi H, Matsuzaki H, Takenobu T, Unetsubo T and Asaumi JI: Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images. Oral Oncol. 47:147–152. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Matsuzaki H, Hara M, Yanagi Y, Asaumi JI, Katase N, Unetsubo T, Hisatomi M, Konouchi H, Takenobu T and Nagatsuka H: Magnetic resonance imaging (MRI) and dynamic MRI evaluation of extranodal non-Hodgkin lymphoma in oral and maxillofacial regions. Oral Surg Oral Med Oral Pathol Oral Radiol. 113:126–133. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Fujita M, Matsuzaki H, Yanagi Y, Hara M, Katase N, Hisatomi M, Unetsubo T, Konouchi H, Nagatsuka H and Asaumi JI: Diagnostic value of MRI for odontogenic tumours. Dentomaxillofac Radiol. 42:201202652013. View Article : Google Scholar : PubMed/NCBI

26 

Schlüter A, Weller P, Kanaan O, Nel I, Heusgen L, Höing B, Haßkamp P, Zander S, Mandapathil M, Dominas N, et al: CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma. BMC Cancer. 18:2722018. View Article : Google Scholar : PubMed/NCBI

27 

Tonino P and Abreu C: Microvessel density is associated with VEGF and α-SMA expression in different regions of human gastrointestinal carcinomas. Cancers (Basel). 3:3405–3418. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Usuda K, Iwai S, Funasaki A, Sekimura A, Motono N, Ueda Y, Shimazaki M and Uramoto H: Expression and prognostic impact of VEGF, CD31 and αSMA in resected primary lung cancers. Anticancer Res. 38:4057–4063. 2018. View Article : Google Scholar : PubMed/NCBI

29 

dela Paz NG, Walshe TE, Leach LL, Saint-Geniez M and D'Amore PA: Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci. 125:831–843. 2012. View Article : Google Scholar : PubMed/NCBI

30 

He J, Chen XF, Xu MG and Zhao J: Relationship of programmed death ligand-1 expression with clinicopathological features and prognosis in patients with oral squamous cell carcinoma: A meta-analysis. Arch Oral Biol. 114:1047172020. View Article : Google Scholar : PubMed/NCBI

31 

Meyer HJ, Höhn AK and Surov A: Associations between histogram analysis parameters derived from dynamic-contrast enhanced MRI and PD L1-expression in head and neck squamous cell carcinomas. A preliminary study. Magn Reson Imaging. 72:117–121. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Toshima T, Harada N, Kohashi K, Oda Y and Mori M: Prognostic impact of tumor microvessels in intrahepatic cholangiocarcinoma: Association with tumor-infiltrating lymphocytes. Mod Pathol. 34:798–807. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Franz L, Alessandrini L, Calvanese L, Crosetta G, Frigo AC and Marioni G: Angiogenesis, programmed death ligand 1 (PD-L1) and immune microenvironment association in laryngeal carcinoma. Pathology. May 13–2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tekiki N, Fujita M, Okui T, Kawai H, Oo MW, Kawazu T, Hisatomi M, Okada S, Takeshita Y, Barham M, Barham M, et al: Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma. Oncol Lett 22: 778, 2021.
APA
Tekiki, N., Fujita, M., Okui, T., Kawai, H., Oo, M.W., Kawazu, T. ... Asaumi, J. (2021). Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma. Oncology Letters, 22, 778. https://doi.org/10.3892/ol.2021.13039
MLA
Tekiki, N., Fujita, M., Okui, T., Kawai, H., Oo, M. W., Kawazu, T., Hisatomi, M., Okada, S., Takeshita, Y., Barham, M., Nagatsuka, H., Yanagi, Y., Asaumi, J."Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma". Oncology Letters 22.5 (2021): 778.
Chicago
Tekiki, N., Fujita, M., Okui, T., Kawai, H., Oo, M. W., Kawazu, T., Hisatomi, M., Okada, S., Takeshita, Y., Barham, M., Nagatsuka, H., Yanagi, Y., Asaumi, J."Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma". Oncology Letters 22, no. 5 (2021): 778. https://doi.org/10.3892/ol.2021.13039
Copy and paste a formatted citation
x
Spandidos Publications style
Tekiki N, Fujita M, Okui T, Kawai H, Oo MW, Kawazu T, Hisatomi M, Okada S, Takeshita Y, Barham M, Barham M, et al: Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma. Oncol Lett 22: 778, 2021.
APA
Tekiki, N., Fujita, M., Okui, T., Kawai, H., Oo, M.W., Kawazu, T. ... Asaumi, J. (2021). Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma. Oncology Letters, 22, 778. https://doi.org/10.3892/ol.2021.13039
MLA
Tekiki, N., Fujita, M., Okui, T., Kawai, H., Oo, M. W., Kawazu, T., Hisatomi, M., Okada, S., Takeshita, Y., Barham, M., Nagatsuka, H., Yanagi, Y., Asaumi, J."Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma". Oncology Letters 22.5 (2021): 778.
Chicago
Tekiki, N., Fujita, M., Okui, T., Kawai, H., Oo, M. W., Kawazu, T., Hisatomi, M., Okada, S., Takeshita, Y., Barham, M., Nagatsuka, H., Yanagi, Y., Asaumi, J."Dynamic contrast‑enhanced MRI as a predictor of programmed death ligand‑1 expression in patients with oral squamous cell carcinoma". Oncology Letters 22, no. 5 (2021): 778. https://doi.org/10.3892/ol.2021.13039
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