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Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab

  • Authors:
    • Daisaku Kamiimabeppu
    • Hiroki Osumi
    • Eiji Shinozaki
    • Akira Ooki
    • Takeru Wakatsuki
    • Koichiro Yoshino
    • Taro Sato
    • Izuma Nakayama
    • Mariko Ogura
    • Daisuke Takahari
    • Keisho Chin
    • Kensei Yamaguchi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135‑8550, Japan
    Copyright: © Kamiimabeppu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 783
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    Published online on: September 13, 2021
       https://doi.org/10.3892/ol.2021.13044
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Abstract

Trifluridine (FTD)/tipiracil (TPI) plus bevacizumab (Bev) is a promising late‑line treatment in metastatic colorectal cancer (mCRC). Although chemotherapy‑induced neutropenia (CIN) is a well‑known predictor of FTD/TPI efficacy, whether CIN is a predictive marker of efficacy for FTD/TPI + Bev remains unclear. Thus, the present study aimed to investigate the clinical outcomes of FTD/TPI + Bev and the predictive markers of its efficacy. Clinical data of patients with mCRC who received FTD/TPI + Bev at the Cancer Institute Hospital between January 2017 and August 2020 were retrospectively collected. Disease control rate (DCR), progression‑free survival (PFS), overall survival (OS) and safety were assessed. In addition, subgroup analyses of prognostic and predictive efficacy markers were performed. In total, 94 patients (median age, 60.0 years; age range, 32‑82 years; 37 men and 57 women) were included in the present study. The DCR was 44.7%, the median PFS time was 2.9 months (2.3‑4.1 months) and the median OS time was 10.0 months (7.3‑11.1 months). Grade 3 or 4 CIN within the first cycle of treatment occurred in 27.7% of patients, which was significantly associated with a longer PFS time than those who did not develop CIN [3.8 months (2.3‑8.4 months) vs. 2.7 months (1.8‑4.0 months); P=0.008]. Furthermore, the DCR was higher in patients with grade 3 or 4 CIN within the first cycle of treatment than those without CIN (61.5 vs. 38.2%; P=0.07). Multivariate Cox regression analysis revealed that grade 3 or 4 CIN within the first cycle of treatment are independent predictors for a longer PFS time (P=0.01). Taken together, the results of the present study suggest that grade 3 or 4 CIN within the first cycle of treatment are early predictors of the efficacy of FTD/TPI + Bev.
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Copy and paste a formatted citation
Spandidos Publications style
Kamiimabeppu D, Osumi H, Shinozaki E, Ooki A, Wakatsuki T, Yoshino K, Sato T, Nakayama I, Ogura M, Takahari D, Takahari D, et al: Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab. Oncol Lett 22: 783, 2021.
APA
Kamiimabeppu, D., Osumi, H., Shinozaki, E., Ooki, A., Wakatsuki, T., Yoshino, K. ... Yamaguchi, K. (2021). Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab. Oncology Letters, 22, 783. https://doi.org/10.3892/ol.2021.13044
MLA
Kamiimabeppu, D., Osumi, H., Shinozaki, E., Ooki, A., Wakatsuki, T., Yoshino, K., Sato, T., Nakayama, I., Ogura, M., Takahari, D., Chin, K., Yamaguchi, K."Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab". Oncology Letters 22.5 (2021): 783.
Chicago
Kamiimabeppu, D., Osumi, H., Shinozaki, E., Ooki, A., Wakatsuki, T., Yoshino, K., Sato, T., Nakayama, I., Ogura, M., Takahari, D., Chin, K., Yamaguchi, K."Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab". Oncology Letters 22, no. 5 (2021): 783. https://doi.org/10.3892/ol.2021.13044
Copy and paste a formatted citation
x
Spandidos Publications style
Kamiimabeppu D, Osumi H, Shinozaki E, Ooki A, Wakatsuki T, Yoshino K, Sato T, Nakayama I, Ogura M, Takahari D, Takahari D, et al: Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab. Oncol Lett 22: 783, 2021.
APA
Kamiimabeppu, D., Osumi, H., Shinozaki, E., Ooki, A., Wakatsuki, T., Yoshino, K. ... Yamaguchi, K. (2021). Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab. Oncology Letters, 22, 783. https://doi.org/10.3892/ol.2021.13044
MLA
Kamiimabeppu, D., Osumi, H., Shinozaki, E., Ooki, A., Wakatsuki, T., Yoshino, K., Sato, T., Nakayama, I., Ogura, M., Takahari, D., Chin, K., Yamaguchi, K."Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab". Oncology Letters 22.5 (2021): 783.
Chicago
Kamiimabeppu, D., Osumi, H., Shinozaki, E., Ooki, A., Wakatsuki, T., Yoshino, K., Sato, T., Nakayama, I., Ogura, M., Takahari, D., Chin, K., Yamaguchi, K."Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab". Oncology Letters 22, no. 5 (2021): 783. https://doi.org/10.3892/ol.2021.13044
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